Effect of food derived bioactive peptides on gut health and inflammatory mediators in vivo: a systematic review

Role of Food Digestion and Digestive System in the Nutritional, Functional and Health Properties of Food Bioactives

“…Specifically focused on food proteins (Contributions 1–4), these investigations represent not only a key tool to validate in vitro digestion protocols but also allow for the obtention of valuable data that could be applied to physiological and metabolic research studies [ 8 , 9 ]. The fate of food proteins during gastrointestinal digestion and the biological effects of their corresponding released peptides are thus highlighted as an area of intense research in the field of functional foods [ 10 , 11 ]. Hence, food-derived peptides with biological properties at the gastrointestinal level, such as antioxidant and antimicrobial [ 12 ], modulation of inflammation and immune response [ 13 ], chemoprevention of malignant diseases [ 14 ], opioid activity [ 15 ], or anti-diabetic effects [ 16 ], among others, have been reported in various investigations.…”