2001
DOI: 10.2165/00003088-200140001-00003
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Effect of Food on the Pharmacokinetics of a Single Oral Dose of Moxifloxacin 400mg in Healthy Male Volunteers

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Cited by 44 publications
(43 citation statements)
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“…Time-kill assays for isolates demonstrating synergism with certain combination of antimicrobials were repeated to assess for between-day reproducibility. For the same combinations, time-kill assays were repeated using concentrations of antimicrobials close to their maximum serum levels, which are 25 g/mL for imipenem and meropenem [9,14], 40 g/mL for ceftazidime [9] and 3 g/mL for ciprofloxacin and moxifloxacin [15,16]. One growth control was applied.…”
Section: Time-kill Assaysmentioning
confidence: 99%
“…Time-kill assays for isolates demonstrating synergism with certain combination of antimicrobials were repeated to assess for between-day reproducibility. For the same combinations, time-kill assays were repeated using concentrations of antimicrobials close to their maximum serum levels, which are 25 g/mL for imipenem and meropenem [9,14], 40 g/mL for ceftazidime [9] and 3 g/mL for ciprofloxacin and moxifloxacin [15,16]. One growth control was applied.…”
Section: Time-kill Assaysmentioning
confidence: 99%
“…The MICs of rifapentine, isoniazid, and moxifloxacin against the standard strain of M. tuberculosis were 0.125, 0.06, and 0.25 mg/liter, respectively, as determined by the broth macrodilution method. The PAEs of the three antituberculosis agents were assessed using drug concentrations falling into the likely therapeutic ranges in humans (7,17,(19)(20)(21): rifapentine (10 to 20 mg/liter), isoniazid (2 mg/liter), and moxifloxacin (1 to 2 mg/liter). Rifapentine and moxifloxacin drug powders for testing were gifts from d'Aventis Pharmaceutical International (Romainville, France) and Bayer Pharmaceutical (Wuppertal, Germany), respectively.…”
mentioning
confidence: 99%
“…In addition, this study was conducted under fasting conditions because the bioavailability of moxifloxacin has been reported not to be affected by the concomitant intake of food [6].…”
Section: Tolerabilitymentioning
confidence: 99%
“…Moxifloxacin shows linear pharmacokinetics after single doses ranging from 50 to 800 mg [5] and its bioavailability is not affected by the concomitant intake of food [6].…”
Section: Introductionmentioning
confidence: 99%