Effect of Food Reductones, 2,5-Dimethyl-4-hydroxy-3(2<i>H</i>)-furanone (DMHF) and Hydroxyhydroquinone (HHQ), on Lipid Peroxidation and Type IV and I Allergy Responses of Mouse

Mi, Hongbin; Hiramoto, Kazuyuki; Kujirai, Kaori; Ando, Kiyohiro; Ikarashi, Yoshiaki; Kikugawa, Kiyomi

doi:10.1021/jf010556l

Cited by 11 publications

(7 citation statements)

References 37 publications

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“…Long-term supplementation of the component to mice increased lung lipid peroxidation, whereas it decreased liver and kidney lipid peroxidation. 16) Supplementation of the component to rats induced lung and heart lipid peroxidation (unpublished results). Supplementation to mice increased allergen-induced type IV contact allergy responses and type I respiratory allergy responses.…”

Section: Fig 4 Time Course Of the Increase In Hydrogen Peroxide Levmentioning

confidence: 90%

“…14,15) Animal studies of the compound have shown that long-term supplementation of the component to mice remarkably induces lung lipid peroxidation, and enhances type IV and I allergy responses. 16) Our previous study has demonstrated that roasted coffee beans contain 1,2,4-benzenetriol as a major hydrogen peroxide-generating component, causing DNA single strand breaks. 8,9) The presence of this component in coffee has been clarified by its isolation from the complex coffee mixture.…”

Section: Fig 4 Time Course Of the Increase In Hydrogen Peroxide Levmentioning

confidence: 99%

“…14,15) Moreover, long-term supplementation of the component to mice remarkably induces lung lipid peroxidation, and enhances type IV and I allergy responses. 16) It is important to elucidate the effects of drinking coffee containing 1,2,4-benzenetriol in humans. Recent experiments with healthy volunteers in Singapore have demonstrated that coffee drinking increases urinary hydrogen peroxide levels, suggesting that oxidative stress is induced in human bodies by coffee drinking.…”

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confidence: 99%

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Increased Urinary Hydrogen Peroxide Levels Caused by Coffee Drinking.

Hiramoto

Kida

Kikugawa

2002

Biological & Pharmaceutical Bulletin

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Experiments with volunteers in Singapore have demonstrated that coffee drinking increases urinary hydrogen peroxide levels (Long, Halliwell, Free Rad. Res., 32, 463-467 (2000)). We re-examined the effect of coffee drinking of healthy Japanese subjects on urinary hydrogen peroxide levels. A cup of brewed or canned coffee commercially available in Japan generated 120-420 m mmol hydrogen peroxide in incubation in a neutral medium at 37°C for 6 h. The increased levels were higher than those obtained from a cup of green tea extract or a glass of red wine. After the subject drank a cup of coffee, apparent hydrogen peroxide levels (m mmol/g creatinine) in urine collected 1-2 h after coffee drinking increased 3-10-fold compared to the levels before coffee drinking. The increased urinary hydrogen peroxide levels are likely derived mainly from 1,2,4-benzenetriol excreted in urine, because the major component that generates hydrogen peroxide is found to be 1,2,4-benzenetriol, and storing urine collected after coffee drinking increased hydrogen peroxide levels in a time-dependent fashion. Total hydrogen peroxide equivalent levels excreted in 3 h-urine after coffee drinking were estimated to be 0.5-10% that of coffee consumed. A residual amount of hydrogen peroxide may be retained or consumed in human bodies.

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Section: Fig 4 Time Course Of the Increase In Hydrogen Peroxide Levmentioning

confidence: 90%

Section: Fig 4 Time Course Of the Increase In Hydrogen Peroxide Levmentioning

confidence: 99%

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confidence: 99%

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Increased Urinary Hydrogen Peroxide Levels Caused by Coffee Drinking.

Hiramoto

Kida

Kikugawa

2002

Biological & Pharmaceutical Bulletin

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“…NO and inflammatory mediators, such as tumor necrosis factor-a (TNF-a) released from LPSactivated microglia can damage dopaminergic neurons [15]. The long-term supplementation of BT (1.2%, w/w) increases mouse lipid peroxidation and type IV and I allergy responses [16].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of 1,2,4-benzenetriol on LPS-induced NO production by BV2 microglial cells

Hou

Chen

et al. 2005

J Biomed Sci

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SummaryHydroxyhydroquinone or 1,2,4-benzenetriol (BT) detected in the beverages has a structure that coincides with the water-soluble form of a sesame lignan, sesamol. We previously showed that sesame antioxidants had neuroprotective abilities due to their antioxidant properties and/or inducible nitric oxide synthase (iNOS) inhibition. However, studies show that BT can induce DNA damage through the generation of reactive oxygen species (ROS). Therefore, we were interested to investigate the neuroprotective effect of BT in vitro and in vivo. The results showed that instead of enhancing free radical generation, BT dosedependently (10-100 lM) attenuated nitrite production, iNOS mRNA and protein expression in lipopolysaccharide (LPS)-stimulated murine BV-2 microglia. BT significantly reduced LPS-induced NF-jB and p38 MAPK activation. It also significantly reduced the generation of ROS in H 2 O 2 -induced BV-2 cells and in H 2 O 2 -cellfree conditions. The neuroprotective effect of BT was further demonstrated in the focal cerebral ischemia model of Sprague-Dawley rat. Taken together, the inhibition of LPS-induced nitrite production might be due to the suppression of NF-jB, p38 MAPK signal pathway and the ROS scavenging effect. These effects might help to protect neurons from the ischemic injury.

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“…The compound is mutagenic to Salmonella bacteria (10) and cleaves DNA single strands (3)(4)(5)(6)(7)(8)(9) in the in vitro studies, which is suggested to participate in the carcinogenicity of ben-zene (9). It has been shown that long-term supplementation of the component to mice increases lung lipid peroxidation and enhances type IV and I allergy responses (11).…”

Section: Introductionmentioning

confidence: 99%

Effect of Supplementation of a Reductone in Coffee, Hydroxyhydroquinone, on Lipid Peroxidation and DNA Damage of Rat Organs.

et al. 2002

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The present study was undertaken in order to know the effect of supplementation of a reductone in coffee, hydroxyhydroquinone (HHQ), on lipid peroxidation and DNA damage of rat organs. Wistar male rats were fed a diet containing HHQ at 2.0% (w/w) for 1 wk. The extents of lipid peroxidation of lung and heart were increased by HHQ supplementation but that of liver was not, when assessed by the levels of phospholipid hydroperoxides and thiobarbituric acid-reactive substances. In contrast, the extents of DNA damage of lung, heart and liver were not increased as assessed by the 8-hydroxy-2-deoxyguanosine levels. The results indicate that supplementation of HHQ to rats caused oxidative stress in lung and heart, but did not mediate DNA damage in these organs. The effect of HHQ supplementation on oxidative stress and the relationship between lipid peroxidation and DNA damage are discussed.

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Effect of Food Reductones, 2,5-Dimethyl-4-hydroxy-3(2H)-furanone (DMHF) and Hydroxyhydroquinone (HHQ), on Lipid Peroxidation and Type IV and I Allergy Responses of Mouse

Cited by 11 publications

References 37 publications

Increased Urinary Hydrogen Peroxide Levels Caused by Coffee Drinking.

Increased Urinary Hydrogen Peroxide Levels Caused by Coffee Drinking.

Protective effect of 1,2,4-benzenetriol on LPS-induced NO production by BV2 microglial cells

Effect of Supplementation of a Reductone in Coffee, Hydroxyhydroquinone, on Lipid Peroxidation and DNA Damage of Rat Organs.

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