Effect of forced treadmill exercise on stimulation of BDNF expression, depression symptoms, tactile memory and working memory in LPS-treated rats

Sohroforouzani, Azam Moosavi; Shakerian, Saeid; Ghanbarzadeh, Mohsen; Alaei, Hojjatallah

doi:10.1016/j.bbr.2021.113645

Cited by 20 publications

(14 citation statements)

References 49 publications

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“…Exercise can increase the expression of BDNF in the hippocampus and cortex to promote neurogenesis in the hippocampus, during which the proBDNF content increases, resulting in a decrease in the mBDNF/proBDNF ratio but an increase in BDNF mRNA expression [79]. In addition, exercise can affect the functional integrity of the brain via an impact on neural plasticity, and it can also increase the density of axons and neurons and enhance the expression of BDNF and tropomyosinrelated kinase receptor in the hippocampus [80]. An animal study demonstrated an increase in the survival rate of neural cells and the percent of new cells differentiated into neurons in depressed rats following 1 week of exercise, and that the BDNF mRNA expression in the hippocampus was much higher relative to the control without exercise [81].…”

Section: Sirt1 Mediates Neurogenesis During Exercisementioning

confidence: 99%

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Qiu

Zeng

et al. 2023

Brain Sciences

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The mechanism behind the onset of depression has been the focus of current research in the neuroscience field. Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)), gene expression in the nucleus accumben (NAc) and CA1 region of the hippocampus (e.g., nescient helix-loop-helix2 (NHLH2), monoamine oxidase (MAO-A), and 5-Hydroxyindole-3-acetic acid (5-HIAA)), and neuronal regeneration in the CA3 region of the hippocampus. Exercise is an important means to improve energy metabolism and depression, but it remains to be established how SIRT1 acts during exercise and improves depression. By induction and analysis, SIRT1 can be activated by exercise and then improve the function of the hypothalamic–pituitary–adrenal (HPA) axis by upregulating brain-derived neurotrophic factors (BDNF), inhibit the inflammatory response (suppression of the NF-κB and TNF-α/indoleamine 2,3-dioxygenase (IDO)/5-Hydroxytryptamine (5-HT) pathways), and promote neurogenesis (activation of the insulin-like growth factor1 (IGF-1) and growth-associated protein-43 (GAP-43) pathways, etc.), thereby improving depression. The present review gives a summary and an outlook based on this finding and makes an analysis, which will provide a new rationale and insight for the mechanism by which exercise improves depression.

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Section: Sirt1 Mediates Neurogenesis During Exercisementioning

confidence: 99%

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Qiu

Zeng

et al. 2023

Brain Sciences

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“…Although our previous study has shown that ginsenoside-Rg1 can rescue the decrease of BDNF and p-CREB protein levels induced by LPS treatment, 17,36 and other studies showed that exercise could increase p-CREB and BDNF expression. 50,57,58 The present study showed that the synergized treatment improved BDNF and p-CREB protein expression more significantly in LPS-rats than either ginsenoside-Rg1 or voluntary wheel running, indicating that this synergized treatment exerts more significant therapeutic effects through its neuroprotective capacity based on the p-CREB/BDNF signaling pathways.…”

Section: Food and Function Papermentioning

confidence: 51%

Ginsenoside-Rg1 synergized with voluntary running exercise protects against glial activation and dysregulation of neuronal plasticity in depression

Wang

et al. 2023

Food Funct.

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“…Estrogen has been reported to modulate angiogenesis, and numerous reports indicate that it increases the expression of PDGF, VEGF, and Ang families. Treatment of TPA-stimulated cells with E2 caused a 61% and 190% increase in PDGF-A at 48 and 96 h, respectively (Shanker et al, 1995). In addition, E2 was found to increase expression of the VEGFR in human myometrial microvascular endothelial cells (MEC) (Gargett et al, 2002).…”

Section: Discussionmentioning

confidence: 98%

“…The exercise intensity was gradually increased to 20 m/min on a 0% gradient for 60 min for a period of 8 weeks. It was gradually improved by about 2 m/min and 6–7 min per week (Ko et al., 2018; Sohroforouzani et al., 2022; Sun et al., 2013).…”

Section: Methodsmentioning

confidence: 99%

The effects of treadmill exercise on brain angiogenesis in ovariectomized rats

Yoon,

Jeong,

Yoon

et al. 2023

Physiological Reports

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Menopause is associated with vascular dysfunction attributed to reduced estrogen levels. Exercise has been proposed to promote angiogenesis and vascular dysfunction. However, studies of brain angiogenesis during menopause are limited. We analyzed the effects of exercise on angiogenesis‐related factors in menopausal rat model. Twenty‐week‐old female Sprague–Dawley rats (N = 18) were randomly divided into a normal control group (N, n = 6), an ovariectomized control group (OVX, n = 6), and an ovariectomy + exercise group (OVX‐EX, n = 6). Treadmill exercises were conducted in the OVX‐EX group for 8 weeks (15–60 m/min, 1 h/day, and 5 days/week). The current study showed that the expression of angiogenesis‐related factors (platelet‐derived growth factor subunit A, B, vascular endothelial growth factor, angiopoietin 1, and angiopoietin 2) significantly decreased in the cortex of the OVX group. However, these factors were significantly restored in the cortex of the OVX‐EX group after 8 weeks of treadmill exercise. In summary, estrogen deficiency causes vascular dysfunction by inhibiting the expression of angiogenesis‐related factors. However, exercise can restore angiogenesis‐related factors in OVX rats. Exercise eventually prevents vascular dysfunction in the brain and may help prevent cognitive dysfunction in menopausal women.

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Effect of forced treadmill exercise on stimulation of BDNF expression, depression symptoms, tactile memory and working memory in LPS-treated rats

Cited by 20 publications

References 49 publications

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression

Ginsenoside-Rg1 synergized with voluntary running exercise protects against glial activation and dysregulation of neuronal plasticity in depression

The effects of treadmill exercise on brain angiogenesis in ovariectomized rats

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