Effect of forebrain implants of testosterone or estradiol on scent-marking and sexual behavior in male and female rabbits

Melo, Angel I.; Chirino, Rosario; Jiménez, Angeles; Cuamatzi, Evelia; Beyer, Carlos; González‐Mariscal, Gabriela

doi:10.1016/j.yhbeh.2008.07.006

Cited by 19 publications

(7 citation statements)

References 49 publications

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“…More specifically, animal literature described the effects of forebrain lesions as well as forebrain steroid hormone implants on the expression of mating in male and female rodents and monitored mating-induced immediate-early gene expression in the forebrains of male and female rodents. These animal studies point to the medial preoptic area (male) and the ventromedial nucleus (female) subdivisions of the hypothalamus as critical segments in the circuitry controlling male- and female-typical sexual arousal, respectively, that is shown in response to pheromonal, visual, and auditory stimuli from opposite-sex conspecifics (Alekseyenko et al, 2007; Crews et al, 1993; Melo et al, 2008; Nyby et al, 1992; Robarts and Baum, 2007; Tetel et al, 1994). …”

Section: Discussionmentioning

confidence: 99%

The neural basis of sex differences in sexual behavior: A quantitative meta-analysis

Poeppl

Langguth

Rupprecht

et al. 2016

Frontiers in Neuroendocrinology

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Sexuality as to its etymology presupposes the duality of sexes. Using quantitative neuroimaging meta-analyses, we demonstrate robust sex differences in the neural processing of sexual stimuli in thalamus, hypothalamus, and basal ganglia. In a narrative review, we show how these relate to the well-established sex differences on the behavioral level. More specifically, we describe the neural bases of known poor agreement between self-reported and genital measures of female sexual arousal, of previously proposed male proneness to affective sexual conditioning, as well as hints of unconscious activation of bonding mechanisms during sexual stimulation in women. In summary, our meta-analytic review demonstrates that neurofunctional sex differences during sexual stimulation can account for well-established sex differences in sexual behavior.

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Section: Discussionmentioning

confidence: 99%

The neural basis of sex differences in sexual behavior: A quantitative meta-analysis

Poeppl

Langguth

Rupprecht

et al. 2016

Frontiers in Neuroendocrinology

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“…These findings might reflect a reduced inhibitory action of the VMH on the expression of maternal behavior as, in rats, this structure antagonizes the onset of maternal care (Bridges, Mann, & Coppeta, 1999; Sheehan & Numan, 1997). Moreover, as the VMH is critical for the stimulation of female rabbit sexual behavior by estradiol (Melo et al, 2008), we may speculate that the small numbers of c-FOS-IR cells found in mothers on PPD 1 could also be related with the inhibition of estrous behavior seen during pregnancy (González-Mariscal, Melo, Zavala, & Beyer, 1990; Ramírez & Beyer, 1988). In the MH, on PPD 1, both groups of mothers showed significantly more c-FOS-IR cells than virgins rabbits, an effect no longer evident on PPD 7.…”

Section: Discussionmentioning

confidence: 99%

Motherhood and nursing stimulate c-FOS expression in the rabbit forebrain.

González‐Mariscal

Jiménez²,

Chirino³

et al. 2009

Behavioral Neuroscience

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Mother rabbits nurse once daily with circadian periodicity. The authors investigated brain structures involved in regulating this activity by quantifying c-FOS-immunoreactive (IR) cells in the forebrain of: (1) mothers killed on postpartum Day 1 (PPD 1) after nursing (Group 1) or not given pups (Group 2); (2) mothers killed on PPD 7 after nursing (Group 3) or not given pups on such day (Group 4); (3) unmated virgins (Group 5). Groups 1 through 4 showed similar numbers of c-FOS-IR cells in the preoptic area, an amount around three to fourfold larger than that found in virgins. Nursing increased, on PPD 1 and 7, c-FOS-IR cell number in the lateral septum and paraventricular and supraoptic nuclei. No differences were seen among Groups 1 through 5 in the suprachiasmatic nucleus. In the ventromedial hypothalamus virgins had more c-FOS-IR cells compared with Groups 1 and 2. Results suggest that specific forebrain structures participate in regulating particular aspects of rabbit maternal behavior: the POA and LS seem associated with the establishment of motherhood and the magnocellular nuclei with the occurrence of milk letdown.

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“…Lesions of this area did not impair CSB in cats (Felis catus) (Leedy and Hart, 1985) and even facilitated copulation in male rats (Christensen et al, 1977), suggesting an inhibitory role of the VMN on male sexual behavior. Moreover, the role of estrogens in this brain region on the control of male sexual behavior is not clear: implants of T or E 2 were found to partially restore sexual behavior of castrated male mice (Nyby et al, 1992) but not of castrated male rabbits (Melo et al, 2008). Interestingly, a recent study, employing stereotaxic injection of a virus containing a small hairpin RNA targeting ERα to knock down its expression in the VMN of male mice reported a decrease in the rate of sexual behavior compared to controls (Sano et al, 2013).…”

Section: Vmnmentioning

confidence: 99%

Site-specific effects of aromatase inhibition on the activation of male sexual behavior in male Japanese quail (Coturnix japonica)

Bournonville

Vandries

Ball

et al. 2019

Hormones and Behavior

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Aromatization within the medial preoptic nucleus (POM) is essential for the expression of male copulatory behavior in Japanese quail. However, several nuclei within the social behavior network (SBN) also express aromatase. Whether aromatase in these loci participates in the behavioral activation is not known. Castrated male Japanese quail were implanted with 2 subcutaneous Silastic capsules filled with crystalline testosterone and with bilateral stereotaxic implants filled with the aromatase inhibitor Vorozole targeting the POM, the bed nucleus of the stria terminalis (BST) or the ventromedial nucleus of the hypothalamus (VMN). Control animals were implanted with testosterone and empty bilateral stereotaxic implants. Starting 2 days after the surgery, subjects were tested for the expression of consummatory sexual behavior (CSB) every other day for a total of 10 tests. They were also tested once for appetitive sexual behavior (ASB) as measured by the rhythmic cloacal sphincter movements displayed in response to the visual presentation of a female. CSB was drastically reduced when the Vorozole implants were localized in the POM, but not in the BST nor in the VMN. Birds with implants in the BST showed a longer latency to show CSB in the first 6 tests than controls, suggesting a role of the BST in the acquisition of the full copulatory ability. ASB was not significantly affected by aromatase blockade in any region. These data confirm the key role played by the POM in the control of male sexual behavior and suggest a minor role for aromatization in the BST or VMN.

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Effect of forebrain implants of testosterone or estradiol on scent-marking and sexual behavior in male and female rabbits

Cited by 19 publications

References 49 publications

The neural basis of sex differences in sexual behavior: A quantitative meta-analysis

The neural basis of sex differences in sexual behavior: A quantitative meta-analysis

Motherhood and nursing stimulate c-FOS expression in the rabbit forebrain.

Site-specific effects of aromatase inhibition on the activation of male sexual behavior in male Japanese quail (Coturnix japonica)

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