Background: Milk production is one of the most important goals pursued by breeders of milk-producing farm animals World Wide. Goats are one of the most important of these animals. This study sought to compare the effect of Saccharomyces cerevisiae yeast (SCY) with or without Selenium and zinc on milk yield and milk nutritional composition and hormones related. Methods: Twenty four female Shami goats distributed into 4 equal groups (6 goats /group) control group (C) animals fed on standard concentrated diet without adding, T2(SCY) animal dosed with S.Cerevisiae at a concentration of 0.2 g/kg of body weight, T3 (Se + Zn) was fed on Selenium and zinc at a concentration of 0.3 and 0.2 g/kg of body weight, respectively, T4 (SCY+Sc +Zn) was represented by dosing their animals with an S.Cerevisiae 0.2g/kg body weight with selenium and zinc added to ratio at same as T3. Result: there was a significant increase (P≤0.05) in the in-milk production, solid-to-fat ratio, milk density and protein level at (SCY+ Sc+Zn) among the transactions, also (SCY+ Sc+ Zn) highlighted a significant increase (P≤0.05) in prolactin, thyroxine and cortisol hormones accompanied by a significant decrease (P≤0.05) in estrogen and triiodothyronine levels in compared to all treated groups.