Effect of Formula Containing <i>Lactobacillus reuteri</i> DSM 17938 on Fecal Microbiota of Infants Born by Cesarean‐Section

Rodenas, Clara L. Garcia; Lepage, Mélissa; Ngom-Bru, Catherine; Fotiou, Aikaterini; Papagaroufalis, Konstantinos; Berger, Bernard

doi:10.1097/mpg.0000000000001198

Cited by 49 publications

(76 citation statements)

References 52 publications

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“…and Lactobacillus spp. relative to infants born by VD, so, in an attempt to restore the GM, these bacteria have been administrated as probiotic supplementation to children born by CS (13,14). Considering the positive effects of dietary XOS on these specific bacteria (27,46,47) and the effect XOS had on the iNKT cell phenotype in CS-delivered pups, it is possible that prebiotic treatments would also turn out to be more effective in humans.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent data adjusting for confounders showed that mode of delivery had no impact on microbial community structure or function beyond six weeks of age (12). Microbial interventions, such as dietary probiotics (13)(14)(15) and "vaginal seeding" (16), when the baby is swabbed in vaginal fluids immediately after CS, have been tried out to restore the early GM composition in CS-delivered infants. Nonetheless, the efficiency of these interventions in restoring the GM is not yet conclusive (15,16), and the causality between CS delivery, skewed bacterial colonization, and development of chronic inflammatory disorders remains to be discovered.…”

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confidence: 99%

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Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice

Zachariassen

Krych

Rasmussen

et al. 2019

The Journal of Immunology

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice

Zachariassen

Krych

Rasmussen

et al. 2019

The Journal of Immunology

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“…Although some probiotic microorganisms have been proven to be efficient in preventing necrotizing enterocolitis and allergy in full-term infants, intervention studies aimed specifically at children born by CS are still scarce and focus specifically on the supplementation of infant formulas. So, a formula containing Lactobacillus reuteri DSM 17938 positively modulated the early development of the microbiota of infants born by CS towards the composition found after VD [32], whereas the addition of the strain Bifidobacterium lactis CNCM I-3446 positively affected the immune and gut functions of CS babies [33]. A recent multicentre study determined that supplementation with a synbiotic combination of galacto-oligosaccharides/fructo-oligosacharides and a Bifidobacterium breve strain counteracted the delayed Bifidobacterium colonization in CS-delivered infants, emulating colonization patterns of VD babies [34].…”

Section: Strategies For Shaping Gut Microbiota and Improving Healthmentioning

confidence: 99%

C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health

et al. 2018

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Background: The human gut microbiota is assembled during infancy with an increase in diversity and stability. The correct colonization and the establishment of this microbiome are linked to the early and future health status of the individual. It is known that caesarean delivery alters this optimal microbial foundation. C-section (CS) is a common obstetrician surgery; however, it is not without risk for the mother/infant dyad. The World Health Organization recommends not exceeding 10–15% of the total deliveries; nevertheless, this rate has been increasing rapidly worldwide in the last decades. Summary: This review discloses the clinical parameters for correct CS recommendation. Moreover, the major microbial changes in the infant gut microbiome acquisition as a consequence of delivery mode and medical practices surrounding it, as well as, the early and long-lasting effects for both mother and babies are discussed. In addition, some strategies for the gut microbiota restoration are analysed. The aim of this review is to show the need for the development of strategies for minimizing or limiting the impact of caesarean on the microbiome development, favouring future health.

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“…In particular, some bacteria have been assigned a role as a keystone species, present at a relatively low abundance but exerting a strong stabilizing influence on the community (18). Only a single study reported such a role for Lactobacillus, specifically, Lactobacillus reuteri DSM 17938 (19). For the human isolate Lactobacillus paracasei subsp.…”

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confidence: 99%

Cross-Feeding among Probiotic Bacterial Strains on Prebiotic Inulin Involves the Extracellular exo -Inulinase of Lactobacillus paracasei Strain W20

Böger

Bueren

Dijkhuizen

2018

Appl Environ Microbiol

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Probiotic gut bacteria employ specific metabolic pathways to degrade dietary carbohydrates beyond the capabilities of their human host. Here, we report how individual commercial probiotic strains degrade prebiotic (inulin type) fructans. First, a structural analysis of commercial fructose oligosaccharide-inulin samples was performed. These β-(2-1)-fructans differ in termination by either glucose (GF) or fructose (FF) residues, with a broad variation in the degrees of polymerization (DPs). The growth of individual probiotic bacteria on short-chain inulin (sc-inulin) (Frutafit CLR), a β-(2-1)-fructan (DP 2 to DP 40), was studied. W57 and other bacteria grew relatively poorly on sc-inulin, with only fractions of DP 3 and DP 5 utilized, reflecting uptake via specific transport systems followed by intracellular metabolism. subsp. W20 completely used all sc-inulin components, employing an extracellular-inulinase enzyme (glycoside hydrolase family GH32 [GH32], also found in other strains of this species); the purified enzyme converted high-DP compounds into fructose, sucrose, 1-kestose, and F2 (inulobiose). The cocultivation of W57 and W20 on sc-inulin resulted in cross-feeding of the former by the latter, supported by this extracellular -inulinase. The extent of cross-feeding depended on the type of fructan, i.e., the GF type (clearly stimulating) versus the FF type (relatively low stimulus), and on fructan chain length, since relatively low-DP β-(2-1)-fructans contain a relatively high content of GF-type molecules, thus resulting in higher concentrations of GF-type DP 2 to DP 3 degradation products. The results provide an example of how cross-feeding on prebiotic β-(2-1)-fructans may occur among probiotic lactobacilli. The human gut microbial community is associated strongly with host physiology and human diseases. This observation has prompted research on pre- and probiotics, two concepts enabling specific changes in the composition of the human gut microbiome that result in beneficial effects for the host. Here, we show how fructooligosaccharide-inulin prebiotics are fermented by commercial probiotic bacterial strains involving specific sets of enzymes and transporters. Cross-feeding strains such as W20 may thus act as keystone strains in the degradation of prebiotic inulin in the human gut, and this strain--inulinase combination may be used in commercial -inulin synbiotics.

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Effect of Formula Containing Lactobacillus reuteri DSM 17938 on Fecal Microbiota of Infants Born by Cesarean‐Section

Cited by 49 publications

References 52 publications

Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice

Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice

C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health

Cross-Feeding among Probiotic Bacterial Strains on Prebiotic Inulin Involves the Extracellular exo -Inulinase of Lactobacillus paracasei Strain W20

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