Effect of formulation variables on drug and polymer release from HPMC-based matrix tablets

Sung, K. C.; Nixon, Phillip R.; Skoug, John W.; Ju, Tingyu; Gao, Ping; Topp, Elizabeth M.; Patel, Mahesh

doi:10.1016/0378-5173(96)04644-3

Cited by 111 publications

(46 citation statements)

References 12 publications

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“…Similar reports were found in literature by Sung et al (1996) that reported no differences on the adinazolam mesilate release between formulations produced with Methocel ® K15M and Methocel ® K100M. They concluded that there were limitations in the polymer viscosity when small amounts are used.…”

Section: Resultssupporting

confidence: 79%

“…Dürig, Venkatesh, and Fassihi (1999) related that magnesium stearate is a critical erosion-controlling excipient, particularly if it is used over 1.0%. In an investigation of controlled release tablets using HPMC, they observed that high levels of magnesium stearate (> 2.5%), influenced the balance between radial and axial Sung et al (1996), they are released preferentially by erosion while soluble drugs can dissolve and diffuse through the hydrated gel layer (Reza, Quadir, Haider, 2003;Ibrhim, Daes, Bangudu, 2000). The dissolution assay results demonstrated that the amount of polymer used was very important to control the drug release.…”

Section: Resultsmentioning

confidence: 99%

“…Several reviews on the use of polymers for controlled release theophylline dosage forms had been reported (Raslan, Maswadeh, 2006;Ikegami, Tagawa, Osawa, 2006). Among the polymers available as possible for matrix-forming materials and multiparticulate systems, such as methacrylic resins, polysaccharidic gel, and hydrophilic polymers, cellulose derivatives appear particularly attractive (Jalal, Zmaily, Najib, 1989;Ford, Rubinstein, Hogan, 1985;Siepmann, Peppas, 2001;Sung et al, 1996;Lopes, Lobo, Costa, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of cellulose polymers type on in vitro controlled release tablets containing theophylline

Ojoe¹,

Miyauchi²,

Kaneko³

et al. 2007

Rev. Bras. Cienc. Farm.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of cellulose polymers type on in vitro controlled release tablets containing theophylline

Ojoe¹,

Miyauchi²,

Kaneko³

et al. 2007

Rev. Bras. Cienc. Farm.

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“…In case of the CS-M containing formulation, a gel transformation occurred which exhibited no disintegration and erosion, maintaining its shape for the duration of the study. This retention of shape ensured steady release of drug and hence prevented dose dumping (20). Overall, CS-M based formulations exhibited an ideal release profile when compared to the commercial brands, thus demonstrating comparable performance to these polymers.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 81%

Characterization of a novel lyophilized chitosan hydrogel complex for the controlled release of a highly water soluble drug, niacinamide.

Ma¹,

Prabhu²

2011

Int J Drug Del

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The purpose of this research was to prepare and characterize a novel lyophilized chitosan-based hydrogel complex (termed CS-M) for controlled drug delivery applications using a highly water soluble model drug, niacinamide. Characterization studies were undertaken to evaluate the physical-chemical properties, polymer swelling, in vitro controlled release kinetics, tissue bioadhesion, intestinal permeability and stability of the novel chitosan complex. Additionally, a comparative analysis was conducted with commercial polymers namely, Carbopol 974P-NF® and hydroxypropyl methylcellulose (HPMC K4M). FT-IR and 1 H NMR studies confirmed that despite alteration in physical structure and morphology of the chitosan complex the chemical properties remained unchanged, when compared to the parent chitosan compound. Polymer swelling studies showed consistency in the structural integrity and water uptake of CS-M compared to other polymers which showed inconsistent swelling and disintegration behavior over a 5 h period. In vitro controlled release profiles of CS-M showed a slower, more controlled release rate of niacinamide than other polymers indicating the influence of polymer swelling capacity on water uptake and subsequent drug release. CS-M demonstrated an overall increase in bioadhesion to intestinal tissue when compared to commercial polymers at same concentrations. Similarly, drug transport through everted sac intestinal tissue showed enhanced absorption properties of CS-M when compared to other polymers. Finally, a 3 month accelerated stability study showed all polymers including CS-M to be stable when formulated with niacinamide. Overall, the modified chitosan-based hydrogel polymer, CS-M, demonstrated enhanced characteristics indicating its potential to be used as a controlled release excipient in oral drug formulations.

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“…Criteria for selection of drug candidate for GRD [26] The gastricretentive drug delivery systems are suitable for following types of drug therapy.…”

Section: Posturementioning

confidence: 99%

Untitled

Katiyar

2017

AJP

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Floating drug delivery systems (FDDS) are controlled release drug delivery systems, which get retained in the stomach for longer periods, thus helping in absorption of drug for the intended duration of time. Gastricretentive drug delivery devices can be useful for the spatial and temporal delivery of many drugs. In general, drugs with narrow therapeutic window and prone to degradation in intestine and colon along with drugs having low retention time in gastrointestinal tract (GIT) are selected for FDDS which helps drugs to stay long time in stomach thus increasing gastric residence time and reduces dosing frequency. The present review article shows the various methods of FDDS for increasing retention time of drugs in GIT.

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Effect of formulation variables on drug and polymer release from HPMC-based matrix tablets

Cited by 111 publications

References 12 publications

Influence of cellulose polymers type on in vitro controlled release tablets containing theophylline

Influence of cellulose polymers type on in vitro controlled release tablets containing theophylline

Characterization of a novel lyophilized chitosan hydrogel complex for the controlled release of a highly water soluble drug, niacinamide.

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