Effect of four sedative and anesthetic protocols on quantitative thyroid scintigraphy in euthyroid cats

Schaafsma, I. A.; Pollak, Y.W.E.A.; Barthez, Paul Y.

doi:10.2460/ajvr.67.8.1362

Cited by 12 publications

(15 citation statements)

References 14 publications

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“…The recommendation is to use reference intervals established with the same sedative protocol to eliminate potential bias. 75 No correlation was found between total T 4 concentrations and either T/S ratios or percent dose uptakes in these horses. In cats, T/S ratio and percent dose uptake were shown to correlate well with serum T 4 concentration.…”

Section: Resultsmentioning

confidence: 76%

“…Sedation protocol is known to have a significant impact on thyroidal and salivary pertechnetate uptake in cats. 75 It was concluded that changes in salivary and thyroidal uptake with different sedation protocols could lead to an erroneous diagnosis of hyperthyroidism in cats. The recommendation is to use reference intervals established with the same sedative protocol to eliminate potential bias.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of various sedative and anesthetic protocols on quantitative thyroid scintigraphy has been reported for a group of euthyroid cats. 75 The study calculated thyroidal percent dose uptake of pertechnetate and T/S ratio. Time activity curves were generated for thyroid gland uptake, salivary gland uptake and T/S ratio.…”

Section: 73mentioning

confidence: 99%

“…Ideally a standardized protocol would be established. 75 Pertechnetate thyroid scintigraphy in dogs Pertechnetate scintigraphy is most commonly used in dogs to determine the origin and extent of a cervical mass. More recently it has been used quantitatively to evaluate thyroid gland function in patients with low circulating thyroid hormone concentrations secondary to primary hypothyroidism and non-thyroidal illness syndrome (euthyroid sick syndrome).…”

Section: 73mentioning

confidence: 99%

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Quantitative Pertechnetate Thyroid Scintigraphy and the Ultrasonographic Appearance of the Thyroid Gland in Clinically Normal Horses

Davies

Barber

Crisman³

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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Abstract:The purpose of this study was to report the scintigraphic and sonographic appearance of the thyroid gland in clinically normal horses so these modalities could be used to assess the thyroid gland in this species. Horses were divided into two age groups. Group A consisted of 8 horses between 3 and 10 years of age and Group B of 7 horses between 11 and 20 years of age. Total T 4 concentrations were within the laboratory reference interval. Thyroid to salivary (T/S) ratio, percent dose uptake of pertechnetate and thyroid lobe volume were calculated. Echogenicity of thyroid lobes and presence of nodules were documented. The two groups were compared using appropriate parametric and nonparametic tests. Total T 4 concentrations were significantly lower in the older group. Sixty minute mean ± standard deviation (SD) T/S ratios for older versus younger horses were 5.8 ± 3.0 and 5.3 ± 2.2, respectively. Sixty minute median and interquartile ranges for percent dose uptake of pertechnetate for older versus younger horses were 3.64% (1.5 to 3.98%) and 2.55% (2.33 to 2.90%), respectively. Mean ± SD thyroid lobe volumes for older versus younger horses were 18.93 ± 5.16 cm 3 and 13.55 ± 3.56 cm 3 , respectively. Most thyroid lobes were hyper or isoechoic to the sternocephalicus muscle. Prevalence of thyroid nodules did not differ between groups. Older horses had trends for greater T/S ratios, percent dose uptakes and thyroid lobe volumes but had lower total T 4 concentrations. Further studies using scintigraphy and ultrasound in horses with thyroid disease are planned.

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Section: Resultsmentioning

confidence: 76%

Section: Resultsmentioning

confidence: 99%

Section: 73mentioning

confidence: 99%

Section: 73mentioning

confidence: 99%

See 2 more Smart Citations

Quantitative Pertechnetate Thyroid Scintigraphy and the Ultrasonographic Appearance of the Thyroid Gland in Clinically Normal Horses

Davies

Barber

Crisman³

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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“…For example, the effective dose of hypoxia marker 18 F-HX4 estimated from monkey study is significantly higher (42 µSv/MBq) than the results obtained from humans (27 µSv/MBq) [30]. Moreover, although we do not expect that the anesthesia affects the biodistribution and metabolism of 64 Cu-BaBaSar-RGD 2 , it has been found that different anesthetic protocols can result a significant effect on the uptake of many organs [31]. Another issue to be discussed in this study is that we used a single monkey for 3 imaging sessions due to the limitation of monkey number.…”

Section: Discussionmentioning

confidence: 67%

Biodistribution and Radiation Dosimetry of the Integrin Marker 64Cu-BaBaSar-RGD2 Determined from Whole-Body PET/CT in a Non-human Primate

et al. 2017

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Introduction: 64 Cu-BaBaSar-RGD 2 is a positron emission radiotracer taken up by integrin α v β 3 , which is overexpressed in many malignancies. The aim of this study was to evaluate the biodistribution of 64 Cu-BaBaSar-RGD 2 in a non-human primate with positron emission tomography (PET) and to estimate the absorbed doses in major organs for human. Materials and Methods:Whole-body PET imaging was done on a Siemens Biograph scanner with a male macaque monkey. After an i.v. injection of 13.1-19.7 MBq/kg of 64 Cu-BaBaSar-RGD 2 , whole body scan was collected for a total duration of 180 min.Attenuation and scatter corrections were applied to reconstructions of the whole-body emission scan. After image reconstruction, three-dimensional volumes of interest (VOI) were hand-drawn on the PET transaxial or coronal slices of the frame where the organ was most conspicuous. Time-activity curves (TACs) for each VOI were obtained, and residence times of each organ were calculated by integration of the time-activity curves. Human absorbed doses were estimated using the standard human model in OLINDA/EXM software.Results: Injection of 64 Cu-BaBaSar-RGD 2 was well-tolerated in the macaque monkey, with no serious tracer-related adverse events observed. 64 Cu-BaBaSar-RGD 2 was cleared rapidly from the blood pool, with a 12.1-min biological half-life. Increased 64 CuBaBaSar-RGD 2 uptake was observed in the kidneys, and bladder, with mean percentage injected dose (ID%) values at 1 h after injection ∼35.50 ± 6.47 and 36.89 ± 5.48, respectively. The calculated effective dose was 15.30 ± 2.21 µSv/MBq, and the kidneys had the highest absorbed dose at 108.43 ± 16.41 µGy/MBq using the non-voiding model. For an injected activity of 925 MBq 64 Cu for human, the effective dose would be 14.2 ± 2.1 mSv.Discussion: Due to the limited availability of the primates, we evaluated 64 Cu-BaBaSar-RGD 2 in the same monkey using three imaging sessions. Measured absorbed doses and Liu et al.Radiation Dosimetry of 64 Cu-BaBaSar-RGD 2 Determined from Monkey effective doses of 64 Cu-BaBaSar-RGD 2 are comparable to other reported RGDderived radiopharmaceuticals labeled with 64 Cu and 18 F. Therefore, 64 Cu-BaBaSar-RGD 2 can be safely injected into humans for studying integrin α v β 3 expression non-invasively.

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Principles of Anesthesia

Little

2025

The Cat

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Effect of four sedative and anesthetic protocols on quantitative thyroid scintigraphy in euthyroid cats

Abstract: Sedation and anesthesia have a significant effect on thyroid and salivary gland (99m)TcO(4) uptake in euthyroid cats that may interfere with thyroid scintigraphic image interpretation.

Cited by 12 publications

References 14 publications

Quantitative Pertechnetate Thyroid Scintigraphy and the Ultrasonographic Appearance of the Thyroid Gland in Clinically Normal Horses

Quantitative Pertechnetate Thyroid Scintigraphy and the Ultrasonographic Appearance of the Thyroid Gland in Clinically Normal Horses

Biodistribution and Radiation Dosimetry of the Integrin Marker 64Cu-BaBaSar-RGD2 Determined from Whole-Body PET/CT in a Non-human Primate

Principles of Anesthesia

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