Effect of fragmentedLactobacillus amylovorusCP1563 on lipid metabolism in overweight and mildly obese individuals: a randomized controlled trial

Abstract

BackgroundPreviously, we showed that fragmented Lactobacillus amylovorus CP1563 (CP1563) functions as a dual agonist of peroxisome proliferator-activated receptor α and γ in vitro and in vivo.ObjectiveHere, we examined the safety and effect of CP1563 ingestion on body fat in obese class I participants in a double-blinded, placebo-controlled, randomized clinical trial (RCT).DesignIn the RCT, 200 participants with a body mass index (BMI) of 25–30 kg/m2 consumed test beverages with or without 200 mg of CP1563 daily for 12 weeks. In total, 197 subjects completed the study without any adverse effects.ResultsBody fat percentage, whole body fat, and visceral fat were significantly decreased in the test group compared with the placebo group (p<0.001, p<0.001, and p<0.001, respectively). Triglycerides, total cholesterol, LDL-cholesterol, and diastolic blood pressure showed significant reductions in the test group compared with the placebo group (p<0.001, p<0.001, p<0.001, and p<0.001, respectively). Additionally, significant differences in the changes in blood glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and uric acid were observed between the two groups (p<0.001, p=0.004, p<0.001, and p<0.001, respectively). Improvements in anthropometric measurements and markers were observed in obese class I subjects in the test group.ConclusionsDaily consumption of beverages containing fragmented CP1563 for 12 weeks by obese class I subjects improved anthropometric measurements and markers related to lipid and glucose metabolism without any adverse effects. These results suggest that the consumption of foods containing fragmented CP1563 reduces body fat and prevents metabolic syndrome.

Dual function of Lactobacillus kefiri DH5 in preventing high‐fat‐diet‐induced obesity: direct reduction of cholesterol and upregulation of PPAR‐α in adipose tissue

“…PPAR‐α has been used as a target of gene therapy for obesity and dyslipidemia, especially for synthetic agonists such as fibrates . However, emerging studies suggest that pre‐ and probiotics could act as effective PPAR‐α agonists . A recent study showed that the administration of PPAR‐α ‐agonistic probiotics L. amylovorus CP1563 for 12 weeks in the overweight and mildly obese individuals improved the adiposity and lipid and glucose metabolism with no adverse effects .…”

“…that pre-and probiotics could act as effective PPAR-␣ agonists [7,8]. A recent study showed that the administration of PPAR-␣-agonistic probiotics L. amylovorus CP1563 for 12 weeks in the overweight and mildly obese individuals improved the adiposity and lipid and glucose metabolism with no adverse effects [7].…”

Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta‐analysis of randomized controlled trials

“…1). Of the 26 articles which were full text screened, a total of 11 articles did not meet the criteria of inclusion either because the independent effects of probiotics on outcomes were not possible to estimate (23)(24)(25)(26)(27)(28)(29)(30), the probiotic species were not defined (31) or the patients had undergone gastric bypass (32) or lacked sufficient information on the outcomes of interest (33). Finally, 15 articles were included in the systematic review and meta-analysis (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48).…”

Probiotic foods: Benefits to the cereal based Sri Lankan diet

“…For instance, Sugawara et al, (2016) investigated the role of a heattreated strain of Lactobacillus gasseri given daily in a beverage to get 10 10 cells per day, to a group of adults in a randomized placebo controlled study design, and noted the benefits as preventing the degeneration of quality of life and the occurrence of lifestyle-related diseases. In another randomized control trial on obese human subjects where a strain of heat-killed Lactobacillus amylovorus was given on a daily basis in a beverage for 12 weeks, a reduction of obesity was noted (Nakamura et al, 2016). With such findings, the impact of heat-killed microbes in cooked fermented products such as 'hoppers', 'thosai' and 'idli' are yet to be deciphered.…”