Effect of free and nano-encapsulated curcumin on treatment and energetic metabolism of gerbils infected by Listeria monocytogenes

Jaguezeski, Antonise M.; Souza, Carine F.; Perin, Gessica; Reis, João H.; Gomes, Teane Milagres Augusto; Baldissera, Matheus D.; Vaucher, Rodrigo de Almeida; Andrade, Cínthia Melazzo de; Stefani, Lenita M.; Gündel, Samanta da Silva; Ourique, Aline Ferreira; Silva, Aleksandro S. Da

doi:10.1016/j.micpath.2019.103564

Cited by 16 publications

(5 citation statements)

References 52 publications

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“…Free CUR presented a higher antibacterial effect than CUR-loaded nanocapsules of Eudragit L-100 against L. monocytogenes in gerbils [167]. However, animals treated with CUR in nanocapsules showed reduced hepatic injury, evaluated by increased antioxidant capacity, pyruvate kinase, and Na + /K + ATPase activities and decreased lipoperoxidation [167].…”

Section: Cur In Other Polymeric Ddsmentioning

confidence: 98%

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Trigo-Gutierrez

Vega-Chacón

Soares

et al. 2021

IJMS

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Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). However, CUR is hydrophobic, unstable in solutions, and has low bioavailability, which hinders its clinical use. To circumvent these drawbacks, drug delivery systems (DDSs) have been used. In this review, we summarize the DDSs used to carry CUR and their antimicrobial effect against viruses, bacteria, and fungi, including drug-resistant strains and emergent pathogens such as SARS-CoV-2. The reviewed DDSs include colloidal (micelles, liposomes, nanoemulsions, cyclodextrins, chitosan, and other polymeric nanoparticles), metallic, and mesoporous particles, as well as graphene, quantum dots, and hybrid nanosystems such as films and hydrogels. Free (non-encapsulated) CUR and CUR loaded in DDSs have a broad-spectrum antimicrobial action when used alone or as a PS in aPDT. They also show low cytotoxicity, in vivo biocompatibility, and improved wound healing. Although there are several in vitro and some in vivo investigations describing the nanotechnological aspects and the potential antimicrobial application of CUR-loaded DDSs, clinical trials are not reported and further studies should translate this evidence to the clinical scenarios of infections.

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Section: Cur In Other Polymeric Ddsmentioning

confidence: 98%

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Trigo-Gutierrez

Vega-Chacón

Soares

et al. 2021

IJMS

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“…The inhibition of CYP17A1 and CYP19A1 by curcuminoids provides a template for structure modification to produce effective and safe compounds that can target prostate cancer as well as breast cancer. Curcumin-based compounds can be further optimized for delivery as nano formulations, which have been tried in laboratory animals [37,100,101] as well as in human trials and shown to be safe [29,82]. Only a minor effect on CYP21A2 activity by curcuminoids compared to inhibition of CYP17A1 (50% inhibition of 17,20 lyase activity at 5 µg/ml compared to no significant effect on CYP21A2 activity at the same concentration) was observed.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway

Castaño

Parween

Pandey

2019

IJMS

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Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have potent wound healing, anti-inflammatory, and anti-carcinogenic activities. While curcuminoids have been studied for many years, not much is known about their effects on steroid metabolism. Since many anti-cancer drugs target enzymes from the steroidogenic pathway, we tested the effect of curcuminoids on cytochrome P450 CYP17A1, CYP21A2, and CYP19A1 enzyme activities. When using 10 µg/mL of curcuminoids, both the 17α-hydroxylase as well as 17,20 lyase activities of CYP17A1 were reduced significantly. On the other hand, only a mild reduction in CYP21A2 activity was observed. Furthermore, CYP19A1 activity was also reduced up to ~20% of control when using 1–100 µg/mL of curcuminoids in a dose-dependent manner. Molecular docking studies confirmed that curcumin could dock onto the active sites of CYP17A1, CYP19A1, as well as CYP21A2. In CYP17A1 and CYP19A1, curcumin docked within 2.5 Å of central heme while in CYP21A2 the distance from heme was 3.4 Å, which is still in the same range or lower than distances of bound steroid substrates. These studies suggest that curcuminoids may cause inhibition of steroid metabolism, especially at higher dosages. Also, the recent popularity of turmeric powder as a dilatory supplement needs further evaluation for the effect of curcuminoids on steroid metabolism. The molecular structure of curcuminoids could be modified to generate better lead compounds with inhibitory effects on CYP17A1 and CYP19A1 for potential drugs against prostate cancer and breast cancer.

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“…Pregnant goats (midgestation; (85.58 ± 1.08 days of gestation; mean ± SD) were randomly allotted to two equal cohorts, where the first ( n = 6/group) was orally supplemented with CONC (3 mg/kg body weight [BW]; nanocurcumin [NC]) once daily for 32 consecutive days, and the other group was offered physiological saline following the NC group (control). The dose was selected following a previous study in goats (El‐Sherbiny, Fathi, et al, 2022) and another study in gerbils; the later study reported that oral supplementation with 3 mg/kg BW nano CUR surpassed the protective effect of 30 mg/kg mg original CUR (Jaguezeski et al, 2019). Nano formulation exerts a 9‐fold effect than the original molecule (Yu & Huang, 2012).…”

Section: Methodsmentioning

confidence: 99%

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

El‐Sherbiny,

Samir,

Youssef

et al. 2024

Animal Physiology Nutrition

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This experiment was designed to investigate the impact of curcumin‐olive oil nanocomposite (CONC) supplementation on uteroplacental hemodynamics and ultrasonographic measurements as well as maternal oxidative status in midgestating goats. Twelve synchronized pregnant goats (85.58 ± 1.08 days of gestation; mean ± SD) were uniformly assigned to two groups (n = 6/group); the first group received daily oral supplementation of CONC (3 mg/kg body weight; nanocurcumin [NC] group) for 32 days, and the second group was offered physiological saline (control) following the NC group timeline. The goats of both groups were examined at 3‐day intervals for middle uterine (MUA) and umbilical (UMA) arteries hemodynamics (pulsatility index [PI], resistive index [RI], systole/diastole [S/D] and blood flow rate [BFR]) and diameters, uteroplacental thickness (UPT), placentomes' diameter (PD) and echogenicity, steroid hormones (progesterone and estradiol 17β), oxidative biomarkers (total antioxidant capacity [TAC], catalase [CAT], malondialdehyde [MDA]), nitric oxide (NO) and blood cells DNA integrity. The UPT (p = 0.012) and PD (p = 0.021) values were higher in the NC group than in their counterparts' control group (D11–32). There were increases in diameter (p = 0.021 and p = 0.012) and decreases (p = 0.021, p = 0.016 and p = 0.041 [MUA]; p = 0.015, p = 0.023 and p = 0.011 [UMA] respectively) in Doppler indices (PI, RI and S/D) of the MUA and UMA in the NC group compared to the control group (D14–32). On D20–32 (MUA) and D14–32 (UMA), the NC goats had higher BFR than the control group (p = 0.021, 0.018 respectively). The means of blood cells with fragmented DNA were lower (p = 0.022) in the NC group than in the control group on Days 8 and 21 postsupplementation. There were increases in CAT and NO (D20–32; p = 0.022 and p = 0.004 respectively), and TAC (D17–32; p = 0.007) levels in the NC goats compared to the control ones. The NC group had lower (p = 0.029) concentrations of MDA than the control group on Day 20 postsupplementation onward. In conclusion, oral supplementation of CONC improved uteroplacental blood flow and the antioxidant capacity of midgestating goats.

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Effect of free and nano-encapsulated curcumin on treatment and energetic metabolism of gerbils infected by Listeria monocytogenes

Cited by 16 publications

References 52 publications

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

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