Effect of Free Exercise and Rheumatoid Arthritis

Resistance exercise and low‐level laser therapy improves grip strength and morphological aspects in the ankle joint of Wistar rats with experimental arthritis

“…These results corroborate the studies of Kapale et al (2017), in which the immune system cells were described as forming an abnormal fibrous layer of tissues called pannus, which releases substances that accelerate bone erosion and cartilage destruction, leading to loss of its shape and alignment, resulting in deformations (Kapale et al, 2017). These deformations lead the joints to become fixed because of the thick and hardened structure, resulting in edema, articular tissue modification, and atrophy of adjacent structures, such as skin, bones, muscles, nerves, and blood vessel connective tissues, due to disuse (Firestein, 2003).…”

“…Regular exercise has been shown to significantly improve RA injuries associated with joint function, range F I G U R E 5 (a-f) Wistar rats talocrural joint synovial membrane photomicrographs, 28 days after induction of knee arthritis using CFA, sagittal section, and hematoxylin and eosin staining. of motion, and flexibility, decrease pain, improve gait (Kapale et al, 2017;Shih et al, 2006), increase muscle mass, reduce adiposity, and improve muscle strength, physical fitness, fatigue, psychological well-being, and overall life quality (Mcinnes & Schett, 2011). Gomes et al (2013) reported that physical exercise could reduce edema and leukocyte migration in animals with CFA-induced arthritis.…”

“…In the qualitative morphological analysis, articular cartilage with a smaller extracellular matrix amount and chondrocytes with higher density was observed in the AG group. In addition, the superficial zone was completely disorganized with cartilage degradation and pannus, an abnormal layer of tissue that releases substances that accelerate bone erosion and cartilage destruction (Kapale et al, 2017). Regarding the synovial membrane, the subintima revealed angiogenesis with many blood vessels turgid with red blood cells and inflammatory cells inside the vessels.…”

“…Regular exercise has been shown to significantly improve RA injuries associated with joint function, range of motion, and flexibility, decrease pain, improve gait (Kapale et al, 2017; Shih et al, 2006), increase muscle mass, reduce adiposity, and improve muscle strength, physical fitness, fatigue, psychological well‐being, and overall life quality (Mcinnes & Schett, 2011).…”

“…Studies have shown that resistance exercise is effective for RA rehabilitation and causes an increase in range of motion and flexibility, a significant decrease in pain and inflammatory activity, and improvement in gait and general functions (Kapale et al, 2017; Shih et al, 2006). However, evidence suggests no significant improvements or clinically relevant findings (Flint‐Wagner et al, 2009).…”