Effect of freeze-thawing conditions for preparation of chitosan-poly (vinyl alcohol) hydrogels and drug release studies

Figueroa-Pizano, María D.; Vélaz, Itziar; Peñas, Francisco Javier; Zavala-Rivera, Paul; Rosas-Durazo, A.; Maldonado-Arce, Amir; Martínez-Barbosa, María Elisa

doi:10.1016/j.carbpol.2018.05.004

Cited by 138 publications

(101 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Upon thawing, the ice crystals melt, leaving behind pores between cross-linked polymer regions. Repeated freeze-thawing cycles of the polymer solution lead to the formation of crystallites that act as cross-linking sites, so a hydrogel with a high swelling capacity can be produced [125]. AgNP-polymer composite hydrogels can be prepared by introducing pre-formed AgNPs into a water-soluble polymer matrix, or the formation of AgNPs in-situ through chemical reduction in aqueous polymer solution.…”

Section: Synthesis Of Agnps and Their Polymer Nanocompositesmentioning

confidence: 99%

Bactericidal and Cytotoxic Properties of Silver Nanoparticles

Liao

Tjong

2019

IJMS

754

436

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic and healthcare products, antimicrobial textiles, wound dressings, antitumor drug carriers, etc. due to their excellent antimicrobial properties. Accordingly, AgNPs have gained access into our daily life, and the inevitable human exposure to these nanoparticles has raised concerns about their potential hazards to the environment, health, and safety in recent years. From in vitro cell cultivation tests, AgNPs have been reported to be toxic to several human cell lines including human bronchial epithelial cells, human umbilical vein endothelial cells, red blood cells, human peripheral blood mononuclear cells, immortal human keratinocytes, liver cells, etc. AgNPs induce a dose-, size- and time-dependent cytotoxicity, particularly for those with sizes ≤10 nm. Furthermore, AgNPs can cross the brain blood barrier of mice through the circulation system on the basis of in vivo animal tests. AgNPs tend to accumulate in mice organs such as liver, spleen, kidney and brain following intravenous, intraperitoneal, and intratracheal routes of administration. In this respect, AgNPs are considered a double-edged sword that can eliminate microorganisms but induce cytotoxicity in mammalian cells. This article provides a state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings. Particular attention is paid to the bactericidal activity and cytotoxic effect in mammalian cells.

show abstract

Section: Synthesis Of Agnps and Their Polymer Nanocompositesmentioning

confidence: 99%

Bactericidal and Cytotoxic Properties of Silver Nanoparticles

Liao

Tjong

2019

IJMS

754

436

View full text Add to dashboard Cite

show abstract

“…Herein, we developed a POCT platform based on hydrogel microneedle patches, which can extract skin ISF, recover target biomarkers and detect biomarkers, for POCT based on skin ISF ( Figure ). The hydrogel microneedle patch was made of PVA and chitosan (CS), in which the biocompatible PVA can form a 3D network by repeated freezing and thawing without any cross‐linking agents, and CS can improve the porosity and water absorption capacity of hydrogel . The phase transition property and 3D network structure of the PVA/CS hydrogel make the microneedle both easy penetration into skin and extraction of sufficient ISF.…”

Section: Introductionmentioning

confidence: 99%

A Hydrogel Microneedle Patch for Point‐of‐Care Testing Based on Skin Interstitial Fluid

Niu

et al. 2020

Adv Healthcare Materials

182

149

View full text Add to dashboard Cite

Skin interstitial fluid (ISF) holds great potential as a highly desirable sample resource for point‐of‐care testing (POCT), where the key is to effectively collect target biomarkers from ISF. Hydrogel microneedle patch has great promise for ISF extraction. However, it is challenging to recover target biomarkers from the extracted skin ISF in hydrogel microneedle patches in an easy‐administrated, fast, and bulky instrument‐free manner. Herein, a hydrogel microneedle patch made of polyvinyl alcohol (PVA) and chitosan (CS) for POCT based on the ISF is developed. The phase transition property of PVA/CS hydrogel makes the microneedles stiff when dry, which is beneficial to easily penetrate into skin. Meanwhile, the highly porous microstructure of hydrogel offers good swelling ability for extraction of ISF and the thermal degradation property of PVA makes it convenient to quickly and efficiently recover target biomarkers from microneedle patch. The capability of this platform for POCT applications is further demonstrated by successful detections of typical biomarkers collected from the mimetic skin and monitoring the glucose level in rabbit skins during a day. The developed hydrogel microneedle patch holds the advantages of extraction of skin ISF and recovery of biomarkers, thus presenting as a powerful platform for skin ISF‐based POCT applications.

show abstract

“…The 3D matrix of chemical hydrogel has cross-links, which are formed by covalent bonds; in the other class, the 3D matrix is formed by physical interactions. Such physical interactions arise due to the presence of (i) groups with opposite electrical charges (electrostatic interactions, as in the case of polyelectrolyte complexes or PECs) and (ii) dipolar or hydrophobic groups (that works for physical hydrogel forming, as is the case of the hydrogels obtained by the process of freezing-thawing) [23,24]. Thus, the use cross-linking agents is not needed for preparing physical hydrogels.…”

Section: Basic Concepts and Useful Properties Of Hydrogelsmentioning

confidence: 99%

Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications

Rufato¹,

Galdino²,

Ody³

et al. 2019

Hydrogels - Smart Materials for Biomedical Applications

View full text Add to dashboard Cite

Chitosan (CS) is a polymer obtained from chitin, being this, after the cellulose, the most abundant polysaccharide. The fact of (i) CS being obtained from renewable sources; (ii) CS to possess capability for doing interactions with different moieties being such capability dependent of pH; (iii) plenty of possibilities for chemical modification of CS; and (iv) tuning the final properties of CS derivatives makes this polymer very interesting in academic and technological points of view. In this way, hydrogels based on CS and on CS derivatives have been widely used for biomedical applications. Other important technological applications can be also cited, such as adsorbent of metals and dyes in wastewater from industrial effluents. In pharmaceutical field, hydrogels based on CS are often used as drugs' and proteins' carrier formulations due to the inherent characteristics such as the biocompatibility, nontoxicity, hydrophilicity, etc. This chapter is an attempt for updating and joining the plenty of available information regarding the preparation, characterization, and biomedical application of hydrogels based on chitosan and chitosan derivatives. More than 260 references are provided, being the majority of them published in the last 10 years.

show abstract

Effect of freeze-thawing conditions for preparation of chitosan-poly (vinyl alcohol) hydrogels and drug release studies

Cited by 138 publications

References 41 publications

Bactericidal and Cytotoxic Properties of Silver Nanoparticles

Bactericidal and Cytotoxic Properties of Silver Nanoparticles

A Hydrogel Microneedle Patch for Point‐of‐Care Testing Based on Skin Interstitial Fluid

Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications

Contact Info

Product

Resources

About