Effect of freshly isolated autologous tissue resident stromal cells on cardiac function and perfusion following acute myocardial infarction

Stem cell induced cardiac regeneration: Fusion/mitochondrial exchange and/or transdifferentiation?

“…One of the most promising approaches to repair infarcted myocardium is based on mesenchymal stem cells (MSCs). [3][4][5][6] MSCs are multipotent, immune-privileged in their undifferentiated state 7,8 and can be expanded easily ex vivo.…”

Tracking Long-Term Survival of Intramyocardially Delivered Human Adipose Tissue-Derived Stem Cells Using Bioluminescence Imaging

“…We have shown that ASCs isolated from various species improve cardiac function after experimental MI. Human ASCs (hASCs) transplanted into hearts of immunodeficient mice directly differentiated into cardiomyocytes and vascular cells, induced angiogenesis, and prevented apoptosis through paracrine pathways, subsequently leading to improvement in cardiac function [3,4]. Autologous pig ASCs demonstrated a beneficial effect on myocardial regeneration through enhancement of angiogenesis [5].…”

The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects

“…All analyses were carried out in triplicate. Adipogenic differentiation was determined in pravastatin-treated and untreated cultures of MSCs using previously described methods (2,33). The adipogenic potential was evaluated by Oil Red O staining and real-time PCR analyses of lineage-specific genes (Diagnostic BioSystems, Pleasanton, CA).…”

“…Mesenchymal stem cells (MSCs) are tissue-resident multipotent stem cells that have shown the ability to proliferate and differentiate into different cell lineages including the mesodermal adipogenic, osteogenic, chondrogenic, and myogenic lines, as well as into mesodermal, hepatogenic, and ectodermal neurogenic lineages (2,4,27,29,49). MSCs have been identified from a variety of tissues including bone marrow, adipose tissue, muscle, and heart (31,32,40,56).…”