Effect of Fructose-Induced Hypertension on the Renin-Angiotensin-Aldosterone System and Atrial Natriuretic Factor

Hwang, I-Shun; Huang, Weimin; Wu, Jian Nan; Shian, L. R.; Reaven, Gerald M.

doi:10.1093/ajh/2.6.424

Cited by 69 publications

(40 citation statements)

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“…The role of the renin-angiotensin system in the pathogenesis of fructose-induced hypertension is not well known. Previous studies have shown a normal plasma renin activity in this experimental model (9). On the other hand, the AT 1 receptor antagonist losartan and an angiotensin-converting enzyme inhibitor attenuated the magnitude of the blood pressure elevation and improved insulin sensitivity in fructose-fed rats (28)(29)(30).…”

Section: Discussionsupporting

confidence: 51%

“…Hypertriglyceridemia, hyperinsulinemia and hypertension are common features of animal models of insulin resistance induced by a high-fructose diet (4)(5)(6)8,9,14). As shown above, fructose-induced hypertension in rats was related to the changes in the sodium/ potassium ratio used in the high-fructose diet, whereas hypertriglyceridemia was present regardless of the blood pressure level (4,6,8,9).…”

Section: Discussionmentioning

confidence: 86%

“…As shown above, fructose-induced hypertension in rats was related to the changes in the sodium/ potassium ratio used in the high-fructose diet, whereas hypertriglyceridemia was present regardless of the blood pressure level (4,6,8,9). Hypertriglyceridemia may be secondary to increases in the very low-density lipoprotein-triglyceride (VLDL-TG) secretion rate since elevations in plasma triacylglycerol levels have been correlated with rises in this rate (8,14,15).…”

Section: Discussionmentioning

confidence: 95%

“…On the other hand, the AT 1 receptor antagonist losartan and an angiotensin-converting enzyme inhibitor attenuated the magnitude of the blood pressure elevation and improved insulin sensitivity in fructose-fed rats (28)(29)(30). Although several reports indicate fructose as a factor involved in hypertension (4,5,9), several investigators have failed to observe an increase in blood pressure in fructose-fed rats (31,32). These apparently conflicting data have been attributed to differences in the composition of the diets and to variable blood pressure responses to fructose among different ages and strains of normotensive rats (31,32).…”

Section: Discussionmentioning

confidence: 99%

“…High-fructose diets are heterogeneous in composition since they include a certain amount of animal lard and since variable amounts of sodium and potassium are present in experimental and control diets (4,8,9). Epidemiological evidence suggests that low potassium intake is associated with the probability of the occurrence of hypertension and stroke.…”

Section: Introductionmentioning

confidence: 99%

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A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats

Bezerra

Ueno

Silva

et al. 2001

Braz J Med Biol Res

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Rats fed a high-fructose diet represent an animal model for insulin resistance and hypertension. We recently showed that a high-fructose diet containing vegetable oil but a normal sodium/potassium ratio induced mild insulin resistance with decreased insulin receptor substrate-1 tyrosine phosphorylation in the liver and muscle of normal rats. In the present study, we examined the mean blood pressure, serum lipid levels and insulin sensitivity by estimating in vivo insulin activity using the 15-min intravenous insulin tolerance test (ITT, 0.5 ml of 6 µg insulin, iv) followed by calculation of the rate constant for plasma glucose disappearance (K itt ) in male Wistar-Hannover rats (110-130 g) randomly divided into four diet groups: control,

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