Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial

Abstract

Epidemiological evidence supports a positive relationship between fruit and vegetable (FV) intake, lung function and chronic obstructive pulmonary disease (COPD). Increasing FV intake may attenuate the oxidative stress and inflammation associated with COPD.An exploratory randomised controlled trial to examine the effect of increased consumption of FV on oxidative stress and inflammation in moderate-to-severe COPD was conducted. 81 symptomatically stable patients with a habitually low FV intake (two or fewer portions of FV per day) were randomised to the intervention group (five or more portions of FV per day) or the control group (two or fewer portions of FV per day). Each participant received self-selected weekly home deliveries of FV for 12 weeks.75 participants completed the intervention. There was a significant between-group change in self-reported FV intake and biomarkers of FV intake (zeaxanthin (p50.034) and b-cryptoxanthin (p50.015)), indicating good compliance; post-intervention intakes in intervention and control groups were 6.1 and 1.9 portions of FV per day, respectively. There were no significant changes in biomarkers of airway inflammation (interleukin-8 and myeloperoxidase) and systemic inflammation (C-reactive protein) or airway and systemic oxidative stress (8-isoprostane).This exploratory study demonstrated that patients with moderate-to-severe COPD were able to comply with an intervention to increase FV intake; however, this had no significant effect on airway or systemic oxidative stress and inflammation.

Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men

“…In particular, higher plasma lipid peroxidation has been associated with higher risk for progression in patients with COPD, while higher catalase and erythrocyte glutathione activities were associated with decreased risk of progression of this disease 29. Some studies, but not all,30 have found significant associations of high fruit and vegetable consumption with reduced levels of oxidative stress31 and inflammation parameters32 as well as with increased levels of antioxidant defence 31. It has been shown that intake of fruits and vegetables rich in vitamin C, β-carotene, flavonoids and other antioxidants is inversely correlated not only with oxidative stress parameters (urinary 8-iso prostaglandin F2α and F2-isoprostane) but also with inflammatory biomarkers (such as C reactive protein, interleukin-6, tumour necrosis factor-α and 15-keto-dihydro-PGF2α metabolite) 32.…”

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

“…Several studies have evaluated the impact of nutritional therapy in COPD patients [3–5]. However, it is still unclear how specific dietary components may influence lung function [6] and important clinical outcomes in patients with COPD [7]. In focus of many studies is the possible relationship between nutritional intake, inflammation, and oxidative stress in patients with COPD [8].…”

Fruits and vegetables: measuring intake and encouraging increased consumption

“…A beneficial effect of increased FV intake on inflammatory markers has been demonstrated in some (40) , but not all (34) studies. In terms of intervention studies with endpoints related to other disease states, no effect of increased FV consumption has been demonstrated on oxidative stress and inflammation in chronic obstructive pulmonary disease (41) , while an effect of increased FV intake on response to vaccination in older people has recently been shown (42) .…”