Effect of fullerene on the dispersibility of nanostructured lipid particles and encapsulation in sterically stabilized emulsions

Kulkarni, Chandrashekhar V.; Moinuddin, Zeinab; Agarwal, Yashasvi

doi:10.1016/j.jcis.2016.07.008

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…Fullerenes and their derivatives have become an important class of n-type semiconducting material since their discovery and large scale production. Their unique optical and electronic properties, including their desirable electron affinity and mobility, suitable energetic bandgap, ease of processing, and good compatibility with other semiconducting materials, have enabled them to be an attractive candidate for a broad range of applications, − in particular their almost ubiquitous use in solution processed organic photovoltaic cells (OPV). − …”

Section: Introductionmentioning

confidence: 99%

Impact of Aggregation on the Photochemistry of Fullerene Films: Correlating Stability to Triplet Exciton Kinetics

Speller

McGettrick

Rice³

et al. 2017

ACS Appl. Mater. Interfaces

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The photochemistry and stability of fullerene films is found to be strongly dependent upon film nanomorphology. In particular, PCBM blend films, dispersed with polystyrene, are found to be more susceptible to photobleaching in air than the more aggregated neat films. This enhanced photobleaching correlated with increased oxygen quenching of PCBM triplet states and the appearance of a carbonyl FTIR absorption band indicative of fullerene oxidation, suggesting PCBM photo-oxidation is primarily due to triplet-mediated singlet oxygen generation. PCBM films were observed to undergo photo-oxidation in air for even modest (≤40 min) irradiation times, degrading electron mobility substantially, indicative of electron trap formation. This conclusion is supported by observation of red shifts in photo- and electro-luminescence with photo-oxidation, shown to be in agreement with time-dependent density functional theory calculations of defect generation. These results provide important implications on the environmental stability of PCBM-based films and devices.

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Section: Introductionmentioning

confidence: 99%

Impact of Aggregation on the Photochemistry of Fullerene Films: Correlating Stability to Triplet Exciton Kinetics

Speller

McGettrick

Rice³

et al. 2017

ACS Appl. Mater. Interfaces

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“…Another hybrid system was prepared from a different elegant carbon nanomaterial, fullerene (C60). The C60 was incorporated in the F127-stabilized O/W nanoparticle system [129] (Figure 8). Although these hybrid nano-systems might be considered [68]; (e) Definition of terms displayed in above graphs (a) to (d).…”

Section: Nano-hybrid Systems Based On Lipid Nanostructuresmentioning

confidence: 99%

“…Another hybrid system was prepared from a different elegant carbon nanomaterial, Cosmetics 2016, 3, 37 9 of 15 fullerene (C 60 ). The C 60 was incorporated in the F127-stabilized O/W nanoparticle system [129] (Figure 8). Although these hybrid nano-systems might be considered non-biocompatible, they could be potential candidates for developing novel and innovative applications in future.…”

Section: Nano-hybrid Systems Based On Lipid Nanostructuresmentioning

confidence: 99%

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Kulkarni

2016

Cosmetics

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A majority of cosmetic products that we encounter on daily basis contain lipid constituents in solubilized or insolubilized forms. Due to their amphiphilic nature, the lipid molecules spontaneously self-assemble into a remarkable range of nanostructures when mixed with water. This review illustrates the formation and finely tunable properties of self-assembled lipid nanostructures and their hierarchically organized derivatives, as well as their relevance to the development of cosmetic formulations. These lipid systems can be modulated into various physical forms suitable for topical administration including fluids, gels, creams, pastes and dehydrated films. Moreover, they are capable of encapsulating hydrophilic, hydrophobic as well as amphiphilic active ingredients owing to their special morphological characters. Nano-hybrid materials with more elegant properties can be designed by combining nanostructured lipid systems with other nanomaterials including a hydrogelator, silica nanoparticles, clays and carbon nanomaterials. The smart materials reviewed here may well be the future of innovative cosmetic applications.

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“…29 However, postpreparation loading of cubosomes may not always be successful according to our work on the encapsulation of fullerenes, which only could be loaded during the preparation of cubosomes; the ones added after their preparation resulted in a strong sedimentation. 30 Therefore, any novel method, including an electroformation (reported in this work), providing mild preparation conditions is highly desirable for noninvasive delivery of sensitive payloads.…”

Section: Introductionmentioning

confidence: 99%

Electroformation of Particulate Emulsions Using Lamellar and Nonlamellar Lipid Self-Assemblies

Bailey¹,

Prabhakaran²,

Vishwapathi³

et al. 2021

Langmuir

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We report on the development of an electroformation technique for the preparation of particulate (particle-based) emulsions. These oil-in-water (here, lipid phase acts as an "oil") emulsions were prepared using nonlamellar lipid phases. Such emulsion particles offer high hydrophobic volumes compared to conventional lipid particles based on lamellar phases (vesicles/liposomes). In addition, the tortuous internal nanostructure contributes through greater surface area per volume of lipid particles allowing an enhanced loading of payloads. The electroformation method makes use of a capacitor formed from two indium tin oxide coated conductive glass surfaces separated by a dielectric aqueous medium. This capacitor setup is enclosed in a custom-designed 3Dprinted unit. Lipid molecules, deposited on conductive surfaces, self-assemble into a nanostructure in the presence of an aqueous medium, which when subjected to an alternating current electric field forms nano-and/or microparticles. Optical microscopy, dynamic light scattering, and small-angle X-ray scattering techniques were employed for micro-and nanostructural analyses of electroformed particles. With this method, it is possible to produce particulate emulsions at a very low (e.g., 0.0005 wt % or 0.5 mg/mL) lipid concentration. We demonstrate an applicability of the electroformation method for drug delivery by preparing lipid particles with curcumin, which is a highly important but water-insoluble medicinal compound. As the method employs gentle conditions, it is potentially noninvasive for the delivery of delicate biomolecules and certain drugs, which are prone to decomposition or denaturation due to the high thermomechanical energy input and/or nonaqueous solvents required for existing methods.

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Effect of fullerene on the dispersibility of nanostructured lipid particles and encapsulation in sterically stabilized emulsions

Cited by 6 publications

References 45 publications

Impact of Aggregation on the Photochemistry of Fullerene Films: Correlating Stability to Triplet Exciton Kinetics

Impact of Aggregation on the Photochemistry of Fullerene Films: Correlating Stability to Triplet Exciton Kinetics

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Electroformation of Particulate Emulsions Using Lamellar and Nonlamellar Lipid Self-Assemblies

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