Effect of Functional Buffalo Cheese on Fatty Acid Profile and Oxidative Status of Liver and Intestine of Mice

Nieuwenhove, Carina Van; Gauffin-Cano, Paola; Pérez-Chaia, Adriana B.; González, Silvia

doi:10.1089/jmf.2010.0061

Cited by 14 publications

(9 citation statements)

References 32 publications

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“…Dietary intake of PUFAs increases intestine MDA production in vivo [29]. It then reacts with nucleic acid bases to form adducts such as the pyrimido [1,2a]purin-10(3H)-one (M 1 dG).…”

Section: Malondialdehyde the Most Mutagenic Product Of Lipid Peroxidmentioning

confidence: 99%

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Cai

Dupertuis

Pichard

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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Recent findings CRC is one of the most overriding threats to public health. Despite a broad range of treatments, up to 50% of patients will inevitably develop incurable metastatic disease. Peroxidation of PUFAs contributes to augmentation of oxidative stress and causes in consequence inflammation, which is one of the possible carcinogenic factors of CRC. End products of PUFAs might be used as biomarkers for CRC detection and surveillance for treatment. They also have cytotoxic effect in CRC cells. Experimental results suggest that v-3 PUFAs could increase the efficacy of radiotherapy and chemotherapy of CRC. SummaryLipid peroxidation, one factor of oxidative stress, might play a paramount role not only in carcinogenesis but also in potential therapeutic strategy on CRC. End products of lipid peroxidation, such as malondialdehyde, 4-hydroxy-2-nonenal, and isoprostanes, could be used as biomarkers for cancer detection, surveillance of treatment outcome and prognostic index for CRC patients. Furthermore, malondialdehyde and 4-hydroxy-2-nonenal have cytotoxic effect not only in normal cells but also in CRC cancer cells, which implies the potential role of PUFAs in CRC treatment.

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“…Dietary intake of PUFAs increases intestine MDA production in vivo [29]. It then reacts with nucleic acid bases to form adducts such as the pyrimido [1,2a]purin-10(3H)-one (M 1 dG).…”

Section: Malondialdehyde the Most Mutagenic Product Of Lipid Peroxidmentioning

confidence: 99%

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Cai

Dupertuis

Pichard

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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“…plantarum , and L . rhamnosus , are known as predominant CLA producing strains ( Van Nieuwenhove et al, 2011 ); however, their CLA productivity varies and is usually limited by multiple factors, including temperature, oxygen availability, substrate concentration, etc. ( Pandit et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Linoleic Acids Overproducing Lactobacillus casei Limits Growth, Survival, and Virulence of Salmonella Typhimurium and Enterohaemorrhagic Escherichia coli

et al. 2018

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Probiotics, particularly lactic acid bacteria, are biologic agents which limit the growth, virulence, and survival/colonization of various enteric bacterial pathogens and serve as potential alternatives to antibiotics. Mechanisms that contribute to this antimicrobial effect include producing bioactive metabolites/acids, increasing nutrient and receptor-mediated competition, and modulating gut microbiome ecology. However, these functions of common probiotic strains are limited due to the finite quantity of metabolites they produce and their total number in the gut ecosystem. Conjugated linoleic acids (CLAs), critical metabolites of Lactobacillus, have multiple beneficial effects on human health including anti-carcinogenesis, anti-inflammation, anti-oxidation, and anti-pathogenicity. In this study, we aim to overexpress the myosin cross-reactive antigen gene (mcra) in Lactobacillus casei (LC) to enhance the production of CLA and investigate its effectiveness against enteric bacterial pathogens, specifically Salmonella enterica serovar Typhimurium (ST) and enterohaemorrhagic Escherichia coli (EHEC). By inserting mcra in L. casei, we generated LC-CLA and found the total linoleic acid production by an individual bacterial cell was raised by 21-fold. The adherence ability of LC-CLA on human epithelial cells increased significantly and LC-CLA competitively excluded both ST and EHEC in a mixed-culture condition. Furthermore, LC-CLA significantly altered the physicochemical properties, biofilm formation abilities, interactions with host cells of both ST and EHEC, and triggered anti-inflammatory activities of host cells. These findings offer insights on applying a genetically engineered probiotic to control gut intestinal infections caused by ST and EHEC and prevent foodborne enteric illness in human.

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“…Fatty acid profile was analyzed according to the method described in Van Nieuwenhove et al (2011). Lipids were first extracted following Folch's (1957) procedure, with a chloroform-methanol mixture (2:1 v/v).…”

Section: Fatty Acid Analysismentioning

confidence: 99%

Characterization of gross composition, energy value, and fatty acid profile of milk from lowland tapir (Tapirusterrestris) during different lactation periods

et al. 2014

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We evaluated gross composition, energy value, and fatty acid profile of colostrum, transitional, and mature milk of lowland tapir (Tapirus terrestris (L., 1758)) from Argentina. Samples were obtained from six healthy animals kept in captive or semicaptive conditions. Protein content varied over time from 6 to 19 g/100 g of milk; carbohydrates varied from 2.4 to 5.4 g/100 g of milk; fat varied from 2.4 to 17.3 g/100 g of milk. Energy value also varied over time, with colostrum having the highest value. Fatty acid profile revealed a unique pattern in tapir milk, characterized by the presence of higher amounts of lauric, myristic, and pentadecanoic acids than in milk from other equids. Traces of conjugated linoleic acid (CLA) were measured, being the only trans fatty acid detected in tapir milk. Neither butyric acid (C4:0) nor fatty acids longer than C18 were found in tapir milk. The characteristics of tapir milk include high concentration of fat, caseins, and whey proteins. Gross composition and saturated fatty acid to unsaturated fatty acid (SFA/UFA) ratio of tapir milk were more similar to that of horse milk than rhinoceros milk. The present study sheds light on tapir fatty acid metabolism and on nutritional requirements of their newborns, which can be used to improve conservation and management strategies. Furthermore, different periods of lactation were evaluated in this species for the first time, thus contributing to the general knowledge of milk from other members of the order Perissodactyla.Résumé : Nous avons évalué la composition brute, la valeur énergétique et le profil des acides gras du colostrum, du lait de transition et du lait mature de tapirs terrestres (Tapirus terrestris (L., 1758)) d'Argentine. Des échantillons ont été obtenus de six animaux en santé gardés dans des conditions de captivité ou de semi-captivité. La concentration de protéines variait dans le temps de 6 à 19 g/100 g de lait, celle de glucides, de 2,4 à 5,4 g/100 g de lait, et celle de lipides, de 2,4 à 17,3 g/100 g de lait. La valeur énergétique variait également dans le temps, le colostrum présentant la valeur la plus élevée. Le profil des acides gras du lait de tapir présentait une distribution singulière caractérisée par des quantités plus importantes des acides laurique, myristique et pentadécanoïque que celles du lait d'autres équidés. Des traces d'acide linoléique conjugué (ALC) ont été mesurées, ce dernier étant le seul acide gras trans détecté dans le lait de tapir. L'acide butyrique (C4:0) et des acides gras plus longs que C18 n'ont pas été détectés. Les caractéristiques du lait de tapir comprennent de fortes concentrations de lipides, de caséines et de protéines de lactosérum. La composition brute et le rapport des acides gras saturés et des acides gras non saturés (AGS/AGN) du lait de tapir ressemblaient plus à ceux du lait de jument qu'à ceux du lait de rhinocéros. L'étude jette un nouvel éclairage sur le métabolisme des acides gras chez les tapirs et sur les besoins nutritifs de leurs nouveau-nés qui peut server à amél...

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Effect of Functional Buffalo Cheese on Fatty Acid Profile and Oxidative Status of Liver and Intestine of Mice

Cited by 14 publications

References 32 publications

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Linoleic Acids Overproducing Lactobacillus casei Limits Growth, Survival, and Virulence of Salmonella Typhimurium and Enterohaemorrhagic Escherichia coli

Characterization of gross composition, energy value, and fatty acid profile of milk from lowland tapir (Tapirusterrestris) during different lactation periods

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