Effect of functional groups on physicochemical and mechanical behavior of biocompatible macroporous hydrogels

Rivero, Rebeca Edith; Alustiza, Fabrisio; Rodríguez, Nancy; Bosch, Pablo; Miras, M.C.; Rivarola, Claudia R.; Barbero, C.

doi:10.1016/j.reactfunctpolym.2015.10.011

Cited by 33 publications

(61 citation statements)

References 55 publications

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“…The Ag-NPs are encapsulated inside the hydrogel and the hydrogel avoids their dispersion and controls the antibacterial agent (Ag + ions) release rate. Some systems are built in order to release Ag-NPs and induce bacterial death by toxicity [10,34]. However, these nanocomposites can avoid the cytotoxic effect of Ag-NPs [35] since only Ag + ions are released.…”

Section: Discussionmentioning

confidence: 99%

“…So, it has been demonstrated that bactericidal properties of Ag-NPs depend on size [9]. We are interested in building biocompatible and antibacterial nanocomposites avoiding the use of a stabilizer and taking advantage of physicochemical properties of biocompatible hydrogels [10] to synthesize inside these antibacterial Ag-NPs. Thereby, these nanocomposite materials could be used as cell scaffold and bio-protective materials able to maintain a pollution free system (cells, foods, etc) for future biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial polymeric nanocomposites synthesized by in-situ photoreduction of silver ions without additives inside biocompatible hydrogel matrices based on N-isopropylacrylamide and derivatives

Monerris¹,

Broglia²,

Yslas³

et al. 2017

Express Polym. Lett.

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Abstract. Synthesis of antibacterial nanocomposite obtained by in-situ photoreduction of Ag+ ions impregnated inside a biocompatible hydrogel matrix is described. Hydrogel matrixes based on N-isopropylacrylamide (PNIPAM) and copolymers are synthesized by free radical polymerization in aqueous medium. The hydrogels are loaded with Ag + ions and then silver nanoparticles (Ag-NPs) are obtained in-situ by application of UV light without using additives. Ag-NPs formation inside hydrogels is confirmed by UV-visible spectroscopy, scanning electronic microscopy (SEM) and transmission electronic microscopy (TEM). An extensive characterization of nanocomposites is performed by determining the partition coefficient of Ag + ions before photoreduction, the Ag-NPs mass loaded per gram of hydrogel as a function of irradiation time, swelling capacity and volume phase transition temperature. Fourier Transform Infrared (FTIR) spectra indicate the loss of some functional groups of the polymer backbone during reduction of Ag + ions whereas 13 C NMR spectra do not show any change in the main carbon chain. Nanocomposites show antibacterial activity against Pseudomonas aeruginosas by release of Ag + ions while Ag-NPs remain inside matrix. Reducing/stabilizing character of hydrogel and antibacterial activity of nanocomposite depend on the chemical composition of the matrix.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial polymeric nanocomposites synthesized by in-situ photoreduction of silver ions without additives inside biocompatible hydrogel matrices based on N-isopropylacrylamide and derivatives

Monerris¹,

Broglia²,

Yslas³

et al. 2017

Express Polym. Lett.

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“…For example, both Plieva et al and Rivero et al have shown that performing the polymerization at subzero temperatures (cryogelation/cryopolymerization) results in partitioning of acrylamide monomer toward the edges of the growing ice crystal, resulting in a macroporous structure with a dense (and strong) acrylamide phase comprising the walls. [103,104] Furthermore, by increasing the amount of initiator from 1.2 to 5%, Plieva et al were able to enhance the compressive strength of these macroporous gels by nearly another order of magnitude. [103] Several groups have also explored freeze/thaw cycling-a process whereby hydrogel precursor materials are sequentially frozen-to induce strong physical crosslinking and enhance the mechanical properties of structured hydrogels.…”

Section: High-strength Hydrogelsmentioning

confidence: 99%

“…In most cases, polymer precursor solutions are frozen and subsequently cryopolymerized through small molecule, [104,[119][120][121] UV, [122][123][124] or radiation [110,118,125] initiated methods; however, physically crosslinked gels have also been reported, [126] including PVA-based anisotropic hydrogels prepared via directional freeze-thawing. [107,109] The direction of ice crystal growth determines the orientation of the pore while the rate of freezing predominantly influences the dimensionality of the aligned structures generated, with slower cooling rates resulting in slower ice crystal growth and ultimately the formation of larger ice platelets and thus larger pores following lyophilization.…”

Section: Wwwadvancedsciencenewscom Wwwadvhealthmatdementioning

confidence: 99%

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Hoare

2017

Adv Healthcare Materials

178

168

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Structured macroporous hydrogels that have controllable porosities on both the nanoscale and the microscale offer both the swelling and interfacial properties of bulk hydrogels as well as the transport properties of “hard” macroporous materials. While a variety of techniques such as solvent casting, freeze drying, gas foaming, and phase separation have been developed to fabricate structured macroporous hydrogels, the typically weak mechanics and isotropic pore structures achieved as well as the required use of solvent/additives in the preparation process all limit the potential applications of these materials, particularly in biomedical contexts. This review highlights recent developments in the field of structured macroporous hydrogels aiming to increase network strength, create anisotropy and directionality within the networks, and utilize solvent‐free or additive‐free fabrication methods. Such functional materials are well suited for not only biomedical applications like tissue engineering and drug delivery but also selective filtration, environmental sorption, and the physical templating of secondary networks.

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“…The mechanical properties of the hydrogels used as matrices and the nanocomposites have been studied previously [46,47,50,57,59,61,64], in the swollen (uncollapsed state). In general, the gels are soft materials with elastic modulus below 10 kPa [64]. The incorporation of the nanomaterial somewhat increase the modulus due to a decrease in the plasticity by the dispersed phase.…”

Section: Inhmentioning

confidence: 99%

Smart Thermomechanochemical Composite Materials Driven by Different Forms of Electromagnetic Radiation

et al. 2020

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Photo-thermo-mechanochemical (P-T-MCh) nanocomposites provide a mechanical and/or chemical output (MCh) in response to a photonic (P) input, with the thermal (T) flux being the coupling factor. The nanocomposite combines a photon absorbing nanomaterial with a thermosensitive hydrogel matrix. Conjugated (absorbing in the near infrared (NIR, 750–850 nm) wavelength range) polymer (polyaniline, PANI) nanostructures are dispersed in cross-linked thermosensitive (poly(N-isopropylacrylamide), PNIPAM) hydrogel matrices, giving the nanocomposite P-T-MCh properties. Since PANI is a conductive polymer, electromagnetic radiation (ER) such as radiofrequency (30 kHz) and microwaves (2.4 GHz) could also be used as an input. The alternating electromagnetic field creates eddy currents in the PANI, which produces heat through the Joule effect. A new kind of “product” nanocomposite is then produced, where ER drives the mechanochemical properties of the material through thermal coupling (electromagnetic radiation thermomechanochemical, ER-T-MCh). Both optical absorption and conductivity of PANI depend on its oxidation and protonation state. Therefore, the ER-T-MCh materials are able to react to the surroundings properties (pH, redox potential) becoming a smart (electromagnetic radiation thermomechanochemical) (sER-T-MCh) material. The volume changes of the sER-T-MCh materials are reversible since the size and shape is recovered by cooling. No noticeable damage was observed after several cycles. The mechanical properties of the composite materials can be set by changing the hydrogel matrix. Four methods of material fabrication are described.

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Effect of functional groups on physicochemical and mechanical behavior of biocompatible macroporous hydrogels

Cited by 33 publications

References 55 publications

Antibacterial polymeric nanocomposites synthesized by in-situ photoreduction of silver ions without additives inside biocompatible hydrogel matrices based on N-isopropylacrylamide and derivatives

Antibacterial polymeric nanocomposites synthesized by in-situ photoreduction of silver ions without additives inside biocompatible hydrogel matrices based on N-isopropylacrylamide and derivatives

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Smart Thermomechanochemical Composite Materials Driven by Different Forms of Electromagnetic Radiation

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