Effect of Furosemide Administration and Upright Position on Plasma Renin Activity and Angiotensin II in Hypertension

Abstract

Both plasma renin activity and angiotensin ‡U during recumbency measured by radioimmuno assay, were normal in essential hypertension, chronic glomerulonephritis and bilateral renal artery stenosis, definitely low in primary aldosteronism, and high in unilateral renal artery stenosis. In normal subjects upright posture and furosemide administration induced an elevation in plasma renin activity; which correlated directly with the elevation in angiotensin ‡U. In general, the increase in plasma renin activity was much larger than that in plasma angiotensin ‡U. Plasma renin activity and angiotensin ‡U did not increase in primary aldosteronism, while markedly increased in unilateral renal artery stenosis during upright posture with furosemide administration. The response of plasma renin activity and angiotensin If in essential hypertension and chronic glomerulonephritis was essentially similar to that observed in normal subjects. The suppression of

Plasma Renin Activity in Hypertensive and Hypotensive Turkeys

“…Reports show that in the human the presence of hypertension does not mean that PRA is going to be beyond the normal range (Fukuchi et al, 1973;Johnston et al, 1973). As observed in this study, PRA or Angiotensin I values were not influenced by blood pressure or body weight.…”

“…Fukuchi et al (1973) reported a range of .13 to 3.00 ng/ml/hr for normal humans and for people with malignant hypertension .72 to 10.0 ng/ml/hr. Kosunen and Pakarinen (1976) reported normal human values to be 2.42 ng/ml/hr, and it was shown that the PRA increased by 108% immediately after exercise (running).…”