1983
DOI: 10.1161/01.hyp.5.6_pt_3.v43
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Effect of furosemide on renal function in the stenotic and contralateral kidneys of patients with renovascular hypertension.

Abstract: SUMMARY In a group of six patients diagnosed as having unilateral renovascular hypertension due to fibromuscular dysplasia, inulin glomerular filtration rate, (GFR) and PAH renal plasma flow, (RPF) clearances, urine flow (V), urine sodium (UV Nl ), potassium (UV K ), urinary excretion of prostaglandin E^ (UV reEj ), thromboxane B 2 (UV TxJ , 2 ), and 6-keto prostaglandin F la (UV^^) were measured in each kidney before and after the i.v. administration of furosemide (20 mg). The basal values of GFR, RPF, UV Ni … Show more

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Cited by 14 publications
(9 citation statements)
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“…However, in the present study UPGE2V of the clipped kidney was significantly lower than the control value. The same re sults were also reported in human RVH [16,17], Since ischemia in the clipped kidney is reduced by a high perfusion pressure during progress of hypertension [23] and PRA in this experiment was at a low level, renal PGE2 synthesis might not be stimulated so highly as that in the early phase. On the other hand, renal PGs production in the nonclipped kidney was reported to increase in the early phase which might be mediated by circulating an giotensin II stimulation [2,[13][14][15][16][17][18]20,21].…”
Section: Discussionsupporting
confidence: 85%
“…However, in the present study UPGE2V of the clipped kidney was significantly lower than the control value. The same re sults were also reported in human RVH [16,17], Since ischemia in the clipped kidney is reduced by a high perfusion pressure during progress of hypertension [23] and PRA in this experiment was at a low level, renal PGE2 synthesis might not be stimulated so highly as that in the early phase. On the other hand, renal PGs production in the nonclipped kidney was reported to increase in the early phase which might be mediated by circulating an giotensin II stimulation [2,[13][14][15][16][17][18]20,21].…”
Section: Discussionsupporting
confidence: 85%
“…Urinary prostaglandins E 2 (PGEJ and 6-keto-F, a (6-keto-PGF,J were measured by radioimmunoassay according to the method previously described. 13 Analysis of variance for randomized block design was used to test the null hypothesis, that there were no changes with each maneuver. The Newman-Keuls test was used to determine significant differences between maneuvers.…”
Section: Methodsmentioning
confidence: 99%
“…It is well known that renal prostaglandins (PGs) have vasodilatory, natriuretic, and diuretic effects [1,2], and synthesis and release of them augment in various renal pathological conditions [2][3][4], In experimental renovas cular hypertension produced by constriction of the unila teral renal artery, some participations of renal PGs in the development and maintenance of hypertension have also been suggested [5][6][7][8][9][10]. In experimental renovascular hy pertension, the initial rise of blood pressure is mainly caused by vasoconstriction due to increased angiotensin II, but the mechanism of the maintenance of hyperten sion has not been obvious [11,12].…”
Section: Introductionmentioning
confidence: 99%