Effect of Furosemide on the Clinical Course of Transient Tachypnea of the Newborn

Wiswell, Thomas E.; Rawlings, James S.; Smith, Franklin R.; Goo, Elwin D.H.

doi:10.1542/peds.75.5.908

Cited by 41 publications

(2 citation statements)

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“…Our study also showed that role of Furosemide in TTN management is insignificant. Similar results were shown by Wiswell and colleagues on 50 infants, 21 and by Karabayir et al, in 2006. 22 Group-C received both IV Furosemide and nebulized Salbutamol.…”

Section: Discussionsupporting

confidence: 89%

Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Khushdil

Ahmed

et al. 2022

PAFMJ

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Objective: To assess and compare the effect of Salbutamol and Furosemide therapy in the management of transient tachypnea of newborn. Study Design: Randomized controlled trial (Registered with Clinical Trials.gov: NCT03208894). Place and Duration of Study: Neonatal Intensive Care Unit of Pakistan Emirates Military Hospital Rawalpindi from Oct 2019 to May 2020. Methodology: A total of 100 newborns were included in the study. They were divided into 4 groups. Group-A received nebulized 0.1ml Salbutamol. Group-B was given single intravenous dose of injection Furosemide at the dose of 2mg per kg. Group-C received both IV Furosemide and nebulized Salbutamol. Control group-D received only supportive care. Results: There were 48 male babies and 52 female babies. The average gestational age was 38.8 ± 6.2 weeks and the average birth weight was 2558 ± 620 grams. Administration of both Salbutamol and IV Furosemide together (group-C) showed significant reduction in the mean duration of oxygen dependency compared to control-group (13.40 ± 3.342 vs 83.64 ± 68.546 hours respectively (p<0.001), as well as the need for mechanical ventilation. The mean duration of oxygen dependency in other two groups (A and B) were also reduced compared to control group, but the results were not statistically significant. Conclusion: Salbutamol and Furosemide when given together tend to reduce the duration of oxygen dependency and need for invasive mechanical ventilation in babies with transient tachypnea of newborn.

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Section: Discussionsupporting

confidence: 89%

Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Khushdil

Ahmed

et al. 2022

PAFMJ

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“…15 A study carried out by Wiswell et al on oral use of Furosemide has not shown any benefit in either the severity or duration of the illness or length of hospitalization. 16 In addition, oxygen supplementation was reduced in those patients with restricted fluids compared to standard fluid therapy. 17 Moresco et al compared different treatment modalities for TTN like inhaled epinephrine and salbutamol, fluid restriction, non-invasive ventilation and Furosemide and found that hospital stays for the Salbutamol Group were significantly shorter than other interventions.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Furosemide in the Management of Transient Tachypnea of Newborn

Ali,

Razzaq,

Shah

et al. 2023

PAFMJ

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Objective: To determine the mean length of hospital stay of term and late preterm infants with transient tachypnea of the newborn treated with intravenous Furosemide compared to the Control Group. Study Design: Quasi-experimental study. Place and Duration of Study: Combined Military Hospital, Kharian, from Apr to Oct 2016. Methodology: All term and late preterm infants with transient tachypnea of new-borns were included in the study. One Group was given IV Furosemide, and the other was taken as control. Two doses of Furosemide were administered IV at 1 mg/kg 12 hours apart. The Control Group were given normal saline 01 ml/kg as a placebo 12 hours apart. Results: It was found that the duration of tachypnea in the Study-Group was less than that of the Control-Group (49.4±7.4 h vs 76.7±4.5h, p-value <0.001). The requirement of oxygen was less in the Treatment Group (53.7±6.6h) as compared to the Control-Group (84.5±4.2h) (p<0.01). The duration of hospitalization in the Study-Group was 71.4±4.9 hours, and in the Control-Group was 100.0±3.7 hours (p-value <0.001). Conclusion: Using intravenous Furosemide in neonates with transient tachypnea of newborns effectively reduces the hospital stay of term and late preterm patients. It reduced the tachypnea and, subsequently, the requirement for oxygen in patients with transient tachypnea in newborns.

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Furosemide for transient tachypnea of the newborn

Vaughan

Whitelaw

2002

Cochrane Database of Systematic Reviews

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Effect of Furosemide on the Clinical Course of Transient Tachypnea of the Newborn

Cited by 41 publications

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Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Intravenous Furosemide in the Management of Transient Tachypnea of Newborn

Furosemide for transient tachypnea of the newborn

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