All-inorganic cesium lead halide perovskites hold great promise for the development of next-generation optoelectronics. However, it remains unexplored how the energetic ions will impact CsPbX3, which may largely limit the application potentials. In this work, we for the first time investigate the interaction between the CsPbX3 and high-energy gallium ions in a broad range of ion doses provided by a focused ion beam (FIB) system. We found that the optical properties of CsPbX3 are highly sensitive to the energetic Ga + ions due to the relatively vulnerable ionic bonding. Specifically, even low-dose Ga + irradiation (~110 15 ions/cm 2 ) can lead to more than one-order-of-magnitude reduction in the photoluminescence (PL) intensity, whcih can be attributed to the combined effects of the formation of vacancy/interstitial defects, generation of metallic Pb-related nonradiative recombination centers and crystal-to-amorphization transition. With the increase of ion dose (~10 17 ions/cm 2 ), the morphology of CsPbX3 can be dramatically altered due to the ion sputtering effect. We demonstrate that both low-and high-dose FIB treatment can be important for realizing the application prospects of CsPbX3 in optical security protection and system-on-a-chip compatible microlasers. Our results offer significant information about the ion impacts on CsPbX3 and offer an enabling tool to manipulate the emission and lasing from CsPbX3, which could push ahead the potential of CsPbX3 in photonics and optoelectronics.