Effect of Gaba-Ergic Substances on Cerebral Blood Flow and Intracellular Ca2+ in Hypokinesia

Hakopian, V.P.; Melkonian, Karine V.; Kevorgian, G. A.; Kanayan, A. S.

doi:10.1007/978-1-4615-5405-9_182

Neurochemistry 1997

DOI: 10.1007/978-1-4615-5405-9_182

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Effect of Gaba-Ergic Substances on Cerebral Blood Flow and Intracellular Ca2+ in Hypokinesia

V.P. Hakopian

Karine V. Melkonian

G. A. Kevorgian

et al.

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2003

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“…Particularly ischemic alterations of the brain were observed. We have been making attempts to find out ways to prevent and treat pathological shifts occurring in hypokinesia using GABA-ergic substances (1,(19)(20)(21). Our investigations showed the intensification of contractile responses of rat isolated vessels to norepinephrine and dopamine and involvement of the endothelium in these processes (3).…”

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The influence of nimodipine on cerebral and general hemodynamics in rats under condition of hypokinesia

Hakopian¹,

Baykov²

2003

Acta Physiologica Hungarica

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The aim of the study was to reveal the influence of nimodipine on cerebral and general hemodynamics at different periods of hypokinesia (HK). The gauging of parameters was carried out under general anesthesia before and at the third minute after intravenous injection of three doses of nimodipine (1, 3 and 10 microg/kg). The local cerebral blood flow (ICBF) was measured with laser-Doppler flowmetry probe placed on the parietal cortex. In the 15-day HK indices did not differ from the control group, only mean the arterial blood pressure (MABP) and resistance of cerebral vessels (CVR) were smaller when the highest dose was used. In the 30- and 45-day HK a statistically significant increase of ICBF and a decrease of CVR and MABP was observed. These changes were more expressed in the 45-day HK, and in the 60-day HK some stabilization of these parameter was noted. Most vividly expressed augmentation of HR, in comparison with the control is revealed at the dose of 10 microg/kg on the 30th day of HK. The deltaHR/deltaMABP ratio was decreased with augmentation of term of the HK, achieving its minimum by the 45th day. However, at the dose of 10 microg/kg in 60-day HK this ratio decreased even more. It has been concluded that HK was able to change the sensitivity to the cerebrovasoselective calcium channel blocker--nimodipine.

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mentioning

confidence: 99%

The influence of nimodipine on cerebral and general hemodynamics in rats under condition of hypokinesia

Hakopian¹,

Baykov²

2003

Acta Physiologica Hungarica

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show abstract

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Effect of Gaba-Ergic Substances on Cerebral Blood Flow and Intracellular Ca2+ in Hypokinesia

Cited by 1 publication

References 4 publications

The influence of nimodipine on cerebral and general hemodynamics in rats under condition of hypokinesia

The influence of nimodipine on cerebral and general hemodynamics in rats under condition of hypokinesia

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