Effect of GABA Extract of Black Sticky Rice with Giant Embryo on Alcohol‐Related Indices After Acute Alcohol Intake in Social Drinkers

Jung, Woo-Young; Kim, Sung‐Gon; Kim, Hyeon-Kyeong; Lee, Jin-Seong; Han, Sang‐Ik; Choe, Sangmin; Son, Beung-Gu

doi:10.1111/acer.12746

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…They suggested that a limited diffusion of GABA from blood into brain induced physiological changes in monoaminergic neurons. Thus, although the results of this study cannot conclusively determine whether BSRGE GABA component can pass through BBB, daily intake of BSRGE in previous studies altered the degree of alcohol intake [11], alcohol-related indices [12] and anxiety-related behaviors [13] and its results may be related to an increase of GABA concentration and neurotransmission in CNS after BSRGE intake.…”

Section: Discussionmentioning

confidence: 70%

“…The changes in 2-h alcohol intake were attributed to higher GABA levels in BSRGE than in the general brown rice. Jung et al [12] reported that alcohol in combination with GABA extract in social drinkers affected alcohol-related indices after binge drinking associated with gender-related differences in sedation. Based on the results of these two studies, BSRGE containing high GABA concentrations might suggest an association with alcohol-related effects and alcohol intake.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations

Jung

Kim

et al. 2019

Psychiatry Investig

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Objective Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is unknown whether the intake of BSRGE affects GABAergic activity of brain directly. The purpose of this study is to elucidate the effect of oral administration of BSRGE on brain GABA concentrations compared with commercially available GABA compound and regular feeds. Methods Twenty-one male C57BL/6 mice were assigned to BSRGE, a regular feed (AIN-76) lacking GABA, and a regular feed containing GABA compound. After feeding freely for 48 h, the cortex and striatum were separated from the brain. An enzyme-linked immunosorbent assay was conducted to measure GABA and glutamate concentrations in mouse brain. Results The GABA concentration of the BSRGE group was higher than that of regular feed and GABA compound group (p<0.001). However, the GABA compound group showed no significant difference from the regular feed group (p=0.50). Conclusion Intake of BSRGE containing high GABA content increased GABA concentrations in mouse brain compared with regular feed unlike GABA compound. The results of this study constitute an important basis for further investigations into the clinical applications of BSRGE.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations

Jung

Kim

et al. 2019

Psychiatry Investig

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The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea

Lee

Yoo

Kim

et al. 2019

Alcohol

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Screening of lactic acid bacteria strains isolated from Iranian traditional dairy products for GABA production and optimization by response surface methodology

Najafi

Vosough

Norouzi

et al. 2023

Sci Rep

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A total of 50 lactic acid bacteria (LAB) isolates from Iranian traditional dairy products (Motal and Lighvan cheeses, and artisanal yogurt) were screened for gamma-aminobutyric acid (GABA) production. Firstly, a rapid colorimetric test was performed to evaluate the glutamate decarboxylase (GAD) activity among the LAB isolates examined. Thin layer chromatography (TLC) was then performed on selected strains to identify isolates with high/moderate GABA producing capacity, and a GABase micro-titer plate assay was employed to quantify GABA. Finally, two Lactococcus (Lac.) lactis strains were selected for GABA production optimization via Response Surface Methodology (RSM) following Central Composite Design (CCD). Forty-one out of the 50 isolates showed GAD activity according to the colorimetric assay. Eight isolates displayed strong GAD activity, while nine showed no activity; low to moderate GAD activity was scored for all other isolates. GABA production was confirmed by TLC in all isolates with high GAD activity and in four selected among isoaltes with moderate activity. Among the Lactococcus strains tested, Lac. lactis 311 and Lac. lactis 491 were the strongest GABA producers with amounts of 3.3 and 1.26 mM, respectively. These two strains were subjected to GABA production optimization applying RSM and CCD on three key variables: Monosodium glutamate concentration (MSG) (between 25 and 150 mM), incubation temperature (between 25 and 37 °C), and pH (between 4.0 and 5.0). Optimal conditions for GABA production by Lac. lactis 311 and Lac. lactis 491 of temperature, pH and MSG concentration were, respectively, 35.4 and 30 °C, pH 4.5 and 4.6, and MSG concentration of 89 and 147.4 mM, respectively. Under the above conditions, the amount of GABA produced by Lac. lactis 311 and Lac. lactis 491 was 0.395 and 0.179 mg/mL, respectively. These strains and the optimal culture conditions determined in this study could be used for the biotechnological production of GABA or applied in food fermentations for the development of naturally GABA-enriched foods.

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Effect of GABA Extract of Black Sticky Rice with Giant Embryo on Alcohol‐Related Indices After Acute Alcohol Intake in Social Drinkers

Abstract: Coadministration of a GABA extract to social drinkers while drinking alcohol is supposed to affect alcohol-related indices in terms of pharmacodynamics and pharmacokinetics and did not induce any adverse events.

Cited by 6 publications

References 20 publications

The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations

The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations

The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea

Screening of lactic acid bacteria strains isolated from Iranian traditional dairy products for GABA production and optimization by response surface methodology

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