Effect of gallic acid on purinergic signaling in lymphocytes, platelets, and serum of diabetic rats

Pereira, Aline da Silva; Oliveira, Lizielle Souza de; Lopes, Thauan Faccin; Baldissarelli, Jucimara; Palma, Taís Vidal; Soares, Mayara Sandrielly Pereira; Spohr, Luíza; Morsch, Vera Maria; Andrade, Cínthia Melazzo de; Schetinger, Maria Rosa Chitolina; Spanevello, Rosélia Maria

doi:10.1016/j.biopha.2018.02.029

Cited by 15 publications

(10 citation statements)

References 43 publications

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“…A number of reports have studied the modulatory effects of GA on different aspects of the immune response [38, 39]. GA attenuates experimental colitis by suppressing IL-6, IL-1β, TNF-α, IL-17 and IFN-γ production and inhibiting p65-NF-κB and IL-6/p-STAT3 (Y705) activation [40].…”

Section: Discussionmentioning

confidence: 99%

Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis

et al. 2019

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Background Multiple sclerosis (MS) is a widespread neurological autoimmune disease that includes episodes of demyelination in the central nervous system (CNS). The accumulated evidence has suggested that aryl hydrocarbon receptor (Ahr), a ligand-activated transcription factor, is a promising treatment target for MS. Thus, the current study aimed to identify a novel Ahr ligand with anti-inflammatory potential in experimental autoimmune encephalomyelitis (EAE). Methods An in silico analysis was carried out to predict interactions between Ahr and potential natural ligands. The effects of a predicted interaction were examined in vitro using CD4 + T cells under T helper17 (Th17) cell-polarizing conditions and lipopolysaccharide (LPS)-stimulated macrophages. Silencing Ahr and microRNA (miR)-132 was achieved by electroporation. Myelin oligodendrocyte glycoprotein (MOG) 35-55 and the adoptive transfer of encephalitogenic CD4 + T cells were used to induce EAE. Results Molecular docking analysis and in vitro data identified gallic acid (GA) as a novel Ahr ligand with potent activation potential. GA induced the expression of Ahr downstream genes, including cytochrome P450 family 1 subfamily A member 1 ( Cyp1a1 ) and the miR-212/132 cluster, and promoted the formation of the Ahr/Ahr nuclear translocator (Arnt) complex. In vivo , GA-treated mice were resistant to EAE and exhibited reduced levels of proinflammatory cytokines and increased levels of transforming growth factor-β (TGF-β). Furthermore, GA reduced infiltration of CD4 + CD45 + T cells and monocytes into the CNS. The anti-inflammatory effects of GA were concomitant with miR-132-potentiated cholinergic anti-inflammation and the regulation of the pathogenic potential of astrocytes and microglia. Inducing EAE by adoptive transfer revealed that CD4 + T cells were not entirely responsible for the ameliorative effects of GA. Conclusion Our findings identify GA as a novel Ahr ligand and provide molecular mechanisms elucidating the ameliorative effects of GA on EAE, suggesting that GA is a potential therapeutic agent to control inflammation in autoimmune diseases such as MS.

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Section: Discussionmentioning

confidence: 99%

Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis

et al. 2019

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“…GA exhibited a protective effect against oxidative stress-induced cellular injury in human lymphocytes through immunomodulatory, antioxidant, and cytoprotective properties ( 134 ) and provided effective prevention against complications relating to immunological and thrombo-regulatory mechanisms via reverting the ATP and ADP hydrolysis and adenosine deaminase activity in lymphocytes, and preventing the increase in nucleoside triphosphate diphosphohydrolase, and adenosine deaminase activities in platelets ( 135 ). Additionally, GA inhibited the production of reactive oxygen species and nitric oxide, proinflammatory cytokine release, and phagocytes-induced lymphocyte proliferation in human peripheral blood mononuclear cells ( 136 ).…”

Section: Ga In Immunomodulationmentioning

confidence: 99%

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

et al. 2020

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Gallic acid (GA) is a naturally occurring polyphenol compound present in fruits, vegetables, and herbal medicines. According to previous studies, GA has many biological properties, including antioxidant, anticancer, anti-inflammatory, and antimicrobial properties. GA and its derivatives have multiple industrial uses, such as food supplements or additives. Additionally, recent studies have shown that GA and its derivatives not only enhance gut microbiome (GM) activities, but also modulate immune responses. Thus, GA has great potential to facilitate natural defense against microbial infections and modulate the immune response. However, the exact mechanisms of GA acts on the GM and immune system remain unclear. In this review, first the physicochemical properties, bioavailability, absorption, and metabolism of GA are introduced, and then we summarize recent findings concerning its roles in gastrointestinal health. Furthermore, the present review attempts to explain how GA influences the GM and modulates the immune response to maintain intestinal health.

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“…Several biological properties are associated with gallic acid, such as antioxidant and anti-inflammatory activity, anti-carcinogenic activity, and antihyperglycemic effects such as lowering glucose and glycosylated hemoglobin levels and increasing insulin levels in experimental diabetes models. This suggests the possibility of using gallic acid as a complementary therapy to hypoglycemic drugs (Oliveira et al, 2016;Pereira et al, 2018. ).…”

Section: Resultsmentioning

confidence: 99%

In vitro bioaccessibility and identification of antioxidant compounds in clarified cashew apple juice ‘cajuína’

Porto-Luz

Soares

Silva

et al. 2020

BJD

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Effect of gallic acid on purinergic signaling in lymphocytes, platelets, and serum of diabetic rats

Cited by 15 publications

References 43 publications

Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis

Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

In vitro bioaccessibility and identification of antioxidant compounds in clarified cashew apple juice ‘cajuína’

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