Effect of gamma-aminobutyric acid on corticosterone secretion: involvement of the noradrenergic system

Míguez, I.; Aldegund, Manuel A.

doi:10.1016/0024-3205(90)90117-a

Cited by 12 publications

(10 citation statements)

References 17 publications

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“…Intracerebroventricular administration of GABA an tagonists has revealed a tonic inhibitory GABAergic tone on the HPA axis [56,[62][63][64], The present results confirm and extend the previous data by showing that a GABAer gic projection responsible for the tonic inhibition of the HPA axis is directed at the dorsomedial hypothalamus. These data infer that apart from the previously proposed inhibitory projection from the DMH to the parvocellular PVN [21], and excitatory projection exists as well.…”

Section: Gabaergic Control O F Circadian Melatonin Releasesupporting

confidence: 82%

GABA Receptors in the Region of the Dorsomedial Hypothalamus of Rats Are Implicated in the Control of Melatonin and Corticosterone Release

Kalsbeek¹,

Drijfhout

Westerink

et al. 1996

Neuroendocrinology

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Recently, anatomical evidence was presented that the mammalian circadian clock located in the suprachiasmatic nuclei (SCN) may utilize GABA to transmit diurnal information to the dorsomedial hypothalamus (DMH). The present study provides further physiological evidence for the involvement of this GABAergic projection in the regulation of diurnal rhythms. Infusion of the GABA agonist muscimol in the region of the DMH completely blocked the daily increase of plasma melatonin during darkness and reduced sympathetic output in the pineal gland resulting in lower pineal melatonin production, as measured with transpineal microdialysis. Further experiments in SCN-lesioned animals indicated that the origin of this inhibitory input to the DMH is indeed the SCN. The results of this study imply that the SCN can influence the sympathetic outflow of the hypothalamus through its GABA-containing projection. Furthermore, the present results probably explain the previously reported strong inhibitory effect of benzodiazepines on plasma melatonin in both animals and humans.

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Section: Gabaergic Control O F Circadian Melatonin Releasesupporting

confidence: 82%

GABA Receptors in the Region of the Dorsomedial Hypothalamus of Rats Are Implicated in the Control of Melatonin and Corticosterone Release

Kalsbeek¹,

Drijfhout

Westerink

et al. 1996

Neuroendocrinology

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“…NMDA blockage and Mg 2+ similarly decrease the activity of the hypothalamocortical pituitary adreno (HPA) system. ACTH release decreased after intracerebroventricular administration of GABA (Miguez and Aldegunde 1990). Similarly, GABA A -benzodiazepine agonists have an HPA system-suppressing e¤ect.…”

Section: Discussionmentioning

confidence: 93%

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Murck¹,

Steiger²

1998

Psychopharmacology

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Disturbances of Mg2+ metabolism have been reported in association with affective disorders, seizures in eclampsia, and alcohol withdrawal. Mg2+ has been reported to have N-methyl-D-aspartate (NMDA)-antagonistic and gamma-aminobutyric acid (GABA)-agonistic properties and modulation of GABA(A)- and NMDA-dependent systems is involved in pharmacological treatment of affective disorders and seizures. We studied the effect of Mg2+ on sleep electroencephalogram (EEG) and nocturnal hormonal secretion in men. Ten normal controls were given MgSO4 (3 g MgSO4 between 2030 hours and 2100 hours, followed by 0.5 g MgSO4 per hour until 0700 hours) or placebo i.v. according to a randomized schedule. The sleep EEG was recorded from 2300 hours to 0700 hours. Blood samples were taken from 2000 hours to 0700 hours for analysis of plasma corticotropin (ACTH), cortisol, growth hormone, prolactin and melatonin. The sleep-EEG power within the spindle frequency range (11.0-12.9 Hz) showed a significant increase in the third sleep cycle, but delta power was unchanged throughout the night. ACTH concentration was suppressed between 2200 hours and 0700 hours. No changes in cortisol, growth hormone prolactin or melatonin release were found. The findings are consistent with the assumption that Mg2+ has GABA(A)-agonistic or NMDA-antagonistic effects on sleep and nocturnal hormonal secretion and hence may be useful in controlling depressive symptoms and seizures.

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“…y-Aminobutyric acid [10] and aspartic acid [11] inhibited corticosterone secretion. Conversely, (3-endorphin [12], glutamic acid [13] and serotonin (5-hydroxytryptamine) [14] stimulated adrenal corticosterone re lease.…”

Section: Introductionmentioning

confidence: 99%

Effects of Melatonin on Hypothalamic γ-Aminobutyric Acid, Aspartic Acid, Glutamic Acid, β-Endorphin and Serotonin Levels in Male Mice

et al. 1995

Neurosignals

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Effects of melatonin on hypothalamic neurotransmitters in male mice were studied. Exogenous melatonin administered intraperitoneally significantly increased (p < 0.05) hypothalamic concentrations of aspartic acid and γ-aminobutyric acid by over 29 and 50% respectively. Conversely, hypothalamic β-endorphin concentration was significantly decreased (p < 0.05) 30 min after melatonin administration with doses between 5- and 100 µg/kg. Similarly, melatonin, at a concentration of 100 µg/kg, decreased (p < 0.05) the serotonin level in mouse hypothalamus by 46%. Melatonin, however, did not affect the concentration of hypothalamic glutamic acid over a dose range of 0.5–300 µg melatonin/kg. Our findings suggested that actions of pineal melatonin in animals such as inhibition on serum corticosterone levels might be mediated by the potentiation of activities of hypothalamic neurons containing γ-aminobutyric acid and aspartic acid or by the inhibition of the β-endorphin and serotonin hypothalamic neurons. The neurons containing glutamic acid in the hypothalamus were, however, not influenced by melatonin. Our results are in line with the suggestion that melatonin actions on adrenal corticosterone release or other endocrine secretions may be mediated by way of its actions on hypothalamic neurotransmitter activities.

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Effect of gamma-aminobutyric acid on corticosterone secretion: involvement of the noradrenergic system

Cited by 12 publications

References 17 publications

GABA Receptors in the Region of the Dorsomedial Hypothalamus of Rats Are Implicated in the Control of Melatonin and Corticosterone Release

GABA Receptors in the Region of the Dorsomedial Hypothalamus of Rats Are Implicated in the Control of Melatonin and Corticosterone Release

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Effects of Melatonin on Hypothalamic γ-Aminobutyric Acid, Aspartic Acid, Glutamic Acid, β-Endorphin and Serotonin Levels in Male Mice

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