Effect of gamma irradiation on cefotaxime in the solid state

Żegota, Henryk; Koprowski, Marek; Zegota, Alicja

doi:10.1016/0969-806x(94)e0028-h

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…1. As for other drugs, its irradiation does not modify its activity (Zegota et al, 1994(Zegota et al, , 1995Basly et al, 1997) but causes colour and odour modifications. These modifications are due to the production of new compounds of radiolytic origin (Zeegers et al, 1993;Varshney and Patel, 1994), and which are potentially toxic Bö gl, 1993a,b, 1994).…”

Section: Introductionmentioning

confidence: 99%

Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime

Barbarin

Rollmann

Tilquin

1999

International Journal of Pharmaceutics

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Radiation sterilisation is a promising method to sterilise pharmaceutical products. However, this process is accompanied by a modification of odour due to volatile compounds formation. The origin of malodorous compounds produced during solid cefotaxime radiosterilisation has been investigated and several mechanisms are proposed to explain their appearance. Moreover, some quantitative data are given. Analysis of the degradation products was performed using a GC-ITD system with an injection by the static headspace technique. It appeared that some of the radio-induced compounds (such as carbon oxide sulfide and carbon disulfide) came from the degradation of the drug itself, whereas the formation of others required the presence of residual solvents which are volatile impurities already present before irradiation. Acetaldehyde directly came from impurities but the appearance of esters and acetaldehyde O-methyloxime was due to the presence of both cefotaxime and residual solvents together. Thus, the residual solvents play a key role in the radiolysis compounds formation (six of eight require the presence of them) and consequently in the modification of odour as well.

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Section: Introductionmentioning

confidence: 99%

Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime

Barbarin

Rollmann

Tilquin

1999

International Journal of Pharmaceutics

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“…Radiolysis products may be formed which might affect the quality of the drug. Even small changes in the structure of drug molecules may lead to the formation of biologically inactive derivatives [17,18]. The hydrogels containing other antibacterial agents were partially affected by gamma-irradiation.…”

Section: November 2009mentioning

confidence: 99%

Preparation and characterization of PVA/PVP/glycerin/antibacterial agent hydrogels using γ-irradiation followed by freeze-thawing

Nho

Lim

Gwon

et al. 2009

Korean J. Chem. Eng.

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Hydrogels for wound dressings from a mixture of poly(vinyl alcohol) (PVA), poly(N-vinylpyrrolidone) (PVP), glycerin and an antibacterial agent were obtained by a γ-irradiation combined with freeze-thawing. The physical properties such as the gelation and swelling degree of the hydrogels were examined. When the PVP/PVA ratio was 6 : 4 (wt%) and prepared by combined irradiation and freeze-thawing, it showed an excellent swelling capacity (>1,200%). The antibacterial effect of the hydrogels containing the antibacterial agents was observed to be effective as the concentration of antibacterial agents increased. The results demonstrated that hydrogel in a proper blending ratio could be used as a wound dressing that can accelerate wound healing with an antibacterial effect.

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“…In some foreign countries, specified indicator microorganisms such as E. coli. and P. aeuruginosa were also detected in many crude drugs (Faver, 1992;Sincolle et al, 1987 (Dam et al, 1990;Kimura et al, 1993;Ohnishi et al, 1993;Ohnishi et al, 1994;Reid, 1995;Wu et al, 1995;Zegota et al, 1995).…”

Section: Introductionmentioning

confidence: 99%