Effect of gamma irradiation on HPMC/ZnO nanocomposite films

Rao, B. Lakshmeesha; Asha, S.; Madhukumar, R.; Latha, S.; Gowda, Mahadeva; Shetty, G. Rajesha; Harish, K. V.; Sangappa,

doi:10.1063/1.4917884

Cited by 3 publications

(2 citation statements)

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“…Combined with the molecular weight measurement results, it can be found that the trends of viscosities decline were the same as that of the molecular weight decrease. HPMC has good lm forming properties and can be used to prepare capsules or as lm coating materials (Rao et al, 2015). In this study, the surface viscosity of a single liquid drop after heating was measured by the adhesive force device, and the physical bonding force of HPMC lm surface was re ected by the adhesive force of the liquid drop surface (Wang et al, 2018).…”

Section: In Uence Of Irradiation Modi Cation On Physical Properties O...mentioning

confidence: 99%

“…Gamma rays are emitted by the Cobalt-60 radioisotope, while EBI is the irradiation of polymer by electron linear accelerator (A. et al, 2022;Hwang et al, 2021). High-energy radiation can activate and excite cellulose molecules, resulting in the breaking of some covalent bonds to form free radicals, which in turn further induce the degradation of cellulose through chain shear or cross-linking reactions, thereby reducing the polymerization degree of cellulose, loosening the structure, reducing the length of chain segments (Dong et al, 2021), and obtaining products with lower viscosity (Rao et al, 2015). An electron beam has high energy e ciency and is capable of regulating the level of irradiation energy.…”

Section: Introductionmentioning

confidence: 99%

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Study on Low Viscosity Hydroxypropyl Methylcellulose Obtained by Electron Beam Irradiation and Its Role in Powder Modification

Cheng,

Wang,

Hong

et al. 2023

Preprint

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In this study, hydroxypropyl Methylcellulose (HPMC) with lower viscosity was obtained by electron beam irradiation (EBI), and its physical modifiers for pharmaceutical powders was investigated when it was used during spray drying. After HPMC was irradiated at a dose of 150 kGy, the main structure of HPMC was not affected, and the substitution degree of methoxy and hydroxypropyl was not destroyed significantly. As the irradiation dose increased from 10 to 150 kGy, the molecular weight and viscosity of HPMC decreased continuously. The results of spray drying showed that HPMC could quickly migrate to the surface of the liquid medicine to cover droplets during spray drying and atomization, which improved the hygroscopicity and increased the softening point of spray-dried powder. And the powder water content is lower. After the powder is prepared into particles, the dissolution rate of particles is faster. Therefore, the modified powder exhibits better physical properties. The low viscosity HPMC obtained by electron beam irradiation is suitable for powder modification materials during spray drying, and is expected to be developed as excipient in traditional Chinese medicine and other industries.

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Section: In Uence Of Irradiation Modi Cation On Physical Properties O...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%