Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis

Golzarand, Mahdieh; Omidian, Mahsa; Toolabi, Karamollah

doi:10.1016/j.ctim.2020.102451

Cited by 20 publications

(10 citation statements)

References 29 publications

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“…cambogia has been used as an herbal weight-reducing agent although its antiobesity effect in humans has been controversial. [14][15][16][17] In addition to its antiobesity effect, its glucose-lowering effect has been reported in several studies [20,30,35] ; however, the underlying mechanisms are poorly understood. In the present study, we demonstrated, for the first time, that 1) G. cambogia increased glucose uptake by stimulating AMPK and downstream signaling pathways in C2C12 myotubes; 2) G. cambogia elevated intracellular Ca 2+ levels and CaMKII phosphorylation, to activate AMPK and GLUT4 translocation in C2C12 myotubes; 3) high-glucose-induced suppression of glucose uptake and related signal transduction were reverted by G. cambogia in C2C12 myotubes; and 4) G. cambogia exerted a hypoglycemic effect in HFD-induced diabetic mice by activating the CaMKII/AMPK/p38/TBC1D4 signaling pathway, which was consistent with the in vitro results.…”

Section: Discussionmentioning

confidence: 99%

“…Garcinia cambogia (G. cambogia) is a fruit native to Southeast Asia. Although human clinical trials on G. cambogia extract, regarding its antiobesity effect, have been controversial, [14][15][16] it has been reported to have inhibitory effects on adipogenesis both in vivo and in vitro. [17][18][19] Previous studies have reported that G. cambogia reduced glucose intolerance and body-weight gain in rats fed a high-fat diet.…”

Section: Introductionmentioning

confidence: 99%

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Garcinia Cambogia Improves High‐Fat Diet‐Induced Glucose Imbalance by Enhancing Calcium/CaMKII/AMPK/GLUT4‐Mediated Glucose Uptake in Skeletal Muscle

Han

Kim

Myung

2022

Molecular Nutrition Food Res

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Scope: Garcinia cambogia (G. cambogia) is known to have antiobesity effects. In this study, the therapeutic effects of G. cambogia on glucose homeostasis in obesity-induced diabetes are explored and the underlying mechanisms are investigated. Methods and results: C2C12 myotubes are treated with G. cambogia; glucose uptake, intracellular Ca 2+ levels, and related alterations in signaling pathways are examined. High-fat diet (HFD)-fed mice are administered G. cambogia for 8 weeks; oral glucose tolerance is evaluated, and the regulation of identified targets of signaling pathways in quadriceps skeletal muscle are examined in vivo. G. cambogia increases glucose uptake in C2C12 myotubes and induces the upregulation of AMPK, ACC, and p38 MAPK phosphorylation. Notably, G. cambogia markedly elevates both intracellular Ca 2+ levels, activating CaMKII, a Ca 2+ -sensing protein, and TBC1D4-mediated GLUT4 translocation, to facilitate glucose uptake. Furthermore, high-glucose-induced inhibition of glucose uptake and signal transduction is reverted by G. cambogia. In an HFD-induced diabetes mouse model, G. cambogia administration results in significant blood glucose-lowering effects, which are attributed to the regulation of targets that have been identified in vitro, in quadricep skeletal muscle. Conclusion: These findings provide new insights into the mechanism by which G. cambogia regulates glucose homeostasis in obesity-induced diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Garcinia Cambogia Improves High‐Fat Diet‐Induced Glucose Imbalance by Enhancing Calcium/CaMKII/AMPK/GLUT4‐Mediated Glucose Uptake in Skeletal Muscle

Han

Kim

Myung

2022

Molecular Nutrition Food Res

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“…The authors pointed out the small sample size of the studies they analyzed and the fact that the studies were conducted over short periods of time [120]. Slightly better slimming effects of Garcinia cambogia supplements were shown by a 2020 meta-analysis of such studies, where taking such supplements for 8-12 weeks resulted in decreases in body weight by −1.34 kg, BMI by −0.99 kg/m 2 , percentage of fat mass by −0.42%, and waist circumference by −4.16 cm compared with the placebo group [121]. Overall, the effectiveness of Garcinia cambogia is believed to be under-researched, and long-term use is not recommended.…”

Section: Dietary Supplements and Weight Lossmentioning

confidence: 99%

Dietary Supplements—For Whom? The Current State of Knowledge about the Health Effects of Selected Supplement Use

Wierzejska

2021

IJERPH

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Dietary supplements are products containing nutrients sold in various medicinal forms, and their widespread use may stem from the conviction that a preparation that looks like a drug must have therapeutic properties. The aim of this scoping review is to present what is known about the effects of using selected dietary supplements in the context of chronic diseases, as well as the risks associated with their use. The literature shows that the taking of vitamin and mineral supplements by healthy people neither lowers their risk of cardiovascular diseases nor prevents the development of malignancies. Many scientific societies recognize that omega-3 fatty acids lower blood triglycerides, but whether taking them prevents heart disease is less clear-cut. Taking weight loss supplements is not an effective method of fighting obesity. Often, some supplements are increasingly sold illegally, which is then also associated with the higher risk that they may be adulterated with banned substances, thus making them even more dangerous and potentially life-threatening. Supplements are necessary in cases of nutrient deficiency; however, even though prescription is not required, their use should be recommended and monitored by a physician.

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“…(-)-HCA is a metabolic regulator of obesity and lipid abnormalities in mammalian systems. It inhibits the enzyme citric acid lyase, which is required in the synthesis of fatty acids, and reduces the body’s ability to form adipose tissue [ 9 , 10 , 11 ]. Along with its weight control properties, various other benefits have also been attributed to this bioactive present in G. cambogia , such as its anti-inflammatory, neuroprotective, antidiabetic, antioxidant, and antimicrobial activities [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Quality Evaluation of Dietary Supplements for Weight Loss Based on Garcinia cambogia

et al. 2022

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Food supplements of plant origin for weight control are increasingly being demanded by consumers as a way to promote good health. Among them, those based on Garcinia cambogia (GCFS) are widely commercialized considering their bioactive properties, mainly due to (-)-hydroxycitric acid ((-)-HCA). However, recently, controversy has arisen over their safety; thus, further research and continuous monitoring of their composition is required. Hence, in this work, a multi-analytical approach was followed to determine not only (-)-HCA but also other constituents of 18 GCFS, which could be used as quality markers to detect fraudulent practices in these samples. Discrepancies between the declared (-)-HCA content and that experimentally determined were detected by LC–UV in 33% of the samples. Moreover, GC–MS analyses of GCFS allowed the detection of different compounds not present in G. cambogia fruits and not declared on supplement labels, probably related to heat exposure or to the addition of excipients or other extracts. This multi-analytical methodology is shown to be advantageous to address different fraudulent practices affecting the quality of these supplements.

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Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis

Cited by 20 publications

References 29 publications

Garcinia Cambogia Improves High‐Fat Diet‐Induced Glucose Imbalance by Enhancing Calcium/CaMKII/AMPK/GLUT4‐Mediated Glucose Uptake in Skeletal Muscle

Garcinia Cambogia Improves High‐Fat Diet‐Induced Glucose Imbalance by Enhancing Calcium/CaMKII/AMPK/GLUT4‐Mediated Glucose Uptake in Skeletal Muscle

Dietary Supplements—For Whom? The Current State of Knowledge about the Health Effects of Selected Supplement Use

Quality Evaluation of Dietary Supplements for Weight Loss Based on Garcinia cambogia

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