Effect of garlic consumption on the argyrophilic nucleolar organiser regions (AgNORs) in splenocytes and thymocytes of rats

Zamani, Alireza; Hoseinipanah, Mohammad; Madadi, Hasan; Arjipour, Mahdi

doi:10.1080/09540105.2011.581271

Cited by 5 publications

(9 citation statements)

References 19 publications

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“…The results published by Zamani et al are inconsistent with the well-recognized antiproliferative effect of garlic in several tumor cells [ 37 , 47 , 87 , 97 , 98 ]. Since the authors showed that garlic may enhance rat splenocytes and thymocytes proliferation.…”

Section: Garlic Preparation Biological Activitiesmentioning

confidence: 87%

“…Compounds, such as ajoenes and alliin, isolated from garlic ethanol extracts selectively inhibited the proliferative response of human peripheral blood cells to lectins [ 46 ]. Surprisingly, Zamani et al showed that garlic possesses the ability to increase lymphocyte proliferation in vivo in the absence of a mitogen [ 47 ]. This group showed that garlic aqueous solution induced an enhancement in lymphocyte proliferation in the spleen and thymus of rats from the garlic fed relative to the control group.…”

Section: Garlic Preparation Biological Activitiesmentioning

confidence: 99%

“…This group showed that garlic aqueous solution induced an enhancement in lymphocyte proliferation in the spleen and thymus of rats from the garlic fed relative to the control group. This stimulatory effect was stronger in thymocytes compared with splenocytes, and nuclei sizes were also smaller in thymocytes due to increased cell proliferation [ 47 ]. Data are summarized in Table 1 about immune cell response.…”

Section: Garlic Preparation Biological Activitiesmentioning

confidence: 99%

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In Vitro and In Vivo Immunomodulator Activities of Allium sativum L.

Moutia

Habti

Badou

2018

Evidence-Based Complementary and Alternative Medicine

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Allium Sativum L. (garlic), which is a species of the onion family, Alliaceae, is one of the most used plants in traditional medicine worldwide. More than 200 chemicals with diverse properties have been found in garlic extracts. Several garlic compounds were suggested to be efficient in improving various pathologies including certain types of cancer. This paper is an overview of data about garlic biological activities in vitro and/or in vivo on immune cells, on the development of certain inflammatory diseases, and on different types of carcinomas and sarcomas. Garlic and its compounds were found to have notable antioxidant properties. Garlic therapeutic potential has also been studied in several inflammatory diseases such as allergic-airway inflammation, inflammatory bowel disease, arthritic rheumatism, and atherosclerosis. Furthermore, garlic was found to be able to maintain the immune system homeostasis and to exhibit beneficial effects on immune cells especially through regulation of proliferation and cytokine gene expression. Finally, we will show how major garlic components such as sulfur compounds and polyphenols might be responsible for the garlic biological activities revealed in different situations. If identified, specific compounds present in garlic could potentially be used in therapy.

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Section: Garlic Preparation Biological Activitiesmentioning

confidence: 87%

Section: Garlic Preparation Biological Activitiesmentioning

confidence: 99%

Section: Garlic Preparation Biological Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro and In Vivo Immunomodulator Activities of Allium sativum L.

Moutia

Habti

Badou

2018

Evidence-Based Complementary and Alternative Medicine

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“…Dietary garlic supplementation and CO treatment showed additive effects on reducing plasma erythropoietin levels in mice. Studies showed that gavage administration of male Wistar rats with garlic solution may enhance lymphocyte proliferation in the spleen and thymus from the rat immune system (Zamani et al 2011 ). In spite of a decline in the average nuclear area and nuclear length of thymocytes from garlic-treated rats, total AgNORs (argyrophilic nucleolar organiser regions) and total AgNORs length increased signifi cantly in the splenocytes and thymocytes of the garlic-treated rats.…”

Section: Immunomodulatory/ Haemagglutination Activitymentioning

confidence: 99%

Allium sativum

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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“…The smears were then labeled and fixed with methanol. Silver nitrate (AgNO 3 ) staining of nucleolar organizer regions was performed as described before (17). Briefly, two volumes of aqueous silver nitrate 50% were mixed with one volume of gelatin 2% (prepared in formic acid 1% v/v) to make silver nitrate staining solution.…”

Section: Agnor Stainingmentioning

confidence: 99%

Effect of 50-Hz Magnetic Fields on Argyrophilic Nucleolar Organizer Regions in Bone Marrow Cells

Rafiee

Abbasi

Alikhani

et al. 2021

Avicenna J Pharm Res

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Background: Exposure to an increasing amount of extremely low-frequency magnetic fields (MFs) causes some adverse effects. Considering a direct association between the sizes and numbers of argyrophilic nucleolar organizer regions (AgNORs) and cell proliferation, this study was conducted to evaluate the effect of 50-Hz MFs on the AgNORs of bone marrow (BM) cells. Methods: Eighty male rats were randomly divided into four exposed groups and one control group. The exposed groups received 50-Hz MFs with magnetic flux densities of 1, 100, 500, and 2000 µT two hours a day for two months. BM cells were aspirated from sacrificed rats’ femoral bones, smeared on glass slides, and then stained with silver nitrate for AgNORs. The area (AA), length (AL), and number (AN) of AgNORs were calculated by a microscope equipped with a camera and Scion Image software in 100 BM cells of each rat. The mean of AA, AL, and AN was computed for each group. Results: AA, AL, and AN significantly reduced in the 1 µT group compared with 2000 µT and control groups. Eventually, there was a nonlinear relationship between the effect of 50-Hz MFs and magnetic flux densities. Conclusion: Overall, 50-Hz MFs with a magnetic flux density of 1 µT reduced AgNORs in BM cells. However, 100, 500, and 2000 µT did not affect AgNORs. Therefore, 50-Hz MFs with low density may suppress BM cell proliferation.

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Effect of garlic consumption on the argyrophilic nucleolar organiser regions (AgNORs) in splenocytes and thymocytes of rats

Cited by 5 publications

References 19 publications

In Vitro and In Vivo Immunomodulator Activities of Allium sativum L.

In Vitro and In Vivo Immunomodulator Activities of Allium sativum L.

Allium sativum

Effect of 50-Hz Magnetic Fields on Argyrophilic Nucleolar Organizer Regions in Bone Marrow Cells

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