Effect of gender, diabetes duration, inflammatory cytokines, and vitamin D level on bone mineral density among Thai children and adolescents with type 1 diabetes

Santiprabhob, Jeerunda; Charoentawornpanich, Parichat; Khemaprasit, Khwanhatai; Manpayak, Teerarat; Kiattisakthavee, Pornpimol; Pipatsathian, Amornrat; Wannasilp, Nilrat; Tangjittipokin, Watip

doi:10.1016/j.bone.2021.116112

Cited by 5 publications

(8 citation statements)

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“…Two out of the six reports were identified from screening reference lists (citation search) (28,29). The other four reports presented body composition measures as background information (30)(31)(32)(33). They were identified during a literature search related to children with T1D (Figure 1).…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

Higher Body Fat in Children and Adolescents With Type 1 Diabetes–A Systematic Review and Meta-Analysis

et al. 2022

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AimsHigher prevalence of overweight and obesity in children and adolescents with type 1 diabetes (T1D) suggests alterations are required in body composition. However, differences in body composition between children with T1D and typically developing children (TDC) have not been synthesized using meta-analysis. Therefore, we conducted a systematic review and meta-analysis to compare body composition between children with T1D and TDC, and to explore the role of disease and non-disease related factors in potential body composition differences.MethodsStudies were performed comparing dual-energy x-ray absorptiometry-acquired total body fat and lean mass, absolute (kg) and relative (%) values, between children with T1D and TDC. We reported mean differences with 95% confidence intervals (CI) from meta-analysis and relative between-group %-differences. We used meta-regression to explore the role of sex, age, height, body mass, body mass index, Hemoglobin A1c, age of onset, disease duration, and insulin dosage in the potential body composition differences between children with T1D and TDC, and subgroup analysis to explore the role of geographic regions (p < 0.05).ResultsWe included 24 studies (1,017 children with T1D, 1,045 TDC) in the meta-analysis. Children with T1D had 1.2 kg more fat mass (kg) (95%CI 0.3 to 2.1; %-difference = 9.3%), 2.3% higher body fat % (0.3–4.4; 9.0%), but not in lean mass outcomes. Age of onset (β = −2.3, −3.5 to −1.0) and insulin dosage (18.0, 3.5–32.6) were negatively and positively associated with body fat % mean difference, respectively. Subgroup analysis suggested differences among geographic regions in body fat % (p < 0.05), with greater differences in body fat % from Europe and the Middle East.ConclusionThis meta-analysis indicated 9% higher body fat in children with T1D. Earlier diabetes onset and higher daily insulin dosage were associated with body fat % difference between children with T1D and TDC. Children with T1D from Europe and the Middle East may be more likely to have higher body fat %. More attention in diabetes research and care toward body composition in children with T1D is needed to prevent the early development of higher body fat, and to minimize the cardiovascular disease risk and skeletal deficits associated with higher body fat.

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Section: Overview Of Included Studiesmentioning

confidence: 99%

Higher Body Fat in Children and Adolescents With Type 1 Diabetes–A Systematic Review and Meta-Analysis

et al. 2022

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“…9 It shows that Tai Chi soft ball exercise can delay the rapid decline of bone mineral density in various parts of the body. 10…”

Section: Discussionmentioning

confidence: 99%

Influence of Tai Chi Softball on Body Composition and Bone Density

2023

Rev Bras Med Esporte

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Introduction Tai Chi Softball fully reflects the most complete and coherent concept of Tai Chi exercise, round and smooth, natural and continuous, and is very suitable for the daily exercise of middle-aged and elderly people. Objective Explore the effect of Tai Chi Softball exercise on body shape and bone mineral density of middle-aged and elderly women. Methods 45 volunteers were recruited and divided into a Tai Chi Softball group and a control group; the Tai Chi Softball group was guided by professional trainers to perform Tai Chi Softball exercises for six months. The control group did not perform Tai Chi Softball exercises and tested various physical indicators for comparison. Results The weight and BMI of middle-aged and elderly women showed a decreasing trend. The abdominal and arm skinfold measurements were significantly different from those before the experiment (P < 0.01). Body fat percentage decreased significantly, and muscle weight increased, showing statistical significance (P < 0.05). Conclusion Tai Chi Softball exercise can alleviate the rapid decline in bone mineral density and bone mineral content in middle-aged and elderly women. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

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“…This study is part of a cross-sectional study investigating bone mineral density among children and adolescents with T1D [ 15 ] that was conducted at the Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, during March 2016 to January 2018. The protocol for this study was approved by the Siriraj Institutional Review Board (SIRB) (COA no.…”

Section: Methodsmentioning

confidence: 99%

“…One hundred children and adolescents with T1D who routinely attended the Diabetes Clinic of the Department of Pediatrics, Siriraj Hospital, were recruited. The inclusion criteria were as follows: (1) diagnosed with T1D for at least 1 year; (2) aged 5–20 years; (3) had not taken drugs that affect bone mineral density (BMD) (e.g., calcium, vitamin D, multivitamin, or corticosteroid) within 6 months prior to enrollment; (4) absence of any diseases that affect vitamin D levels or bone density (e.g., uncontrolled hyperthyroidism, malabsorption syndrome, celiac disease, chronic liver disease, impaired renal function, and bone diseases) [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

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Dietary Intake and Physical Activity of Thai Children and Adolescents with Type 1 Diabetes Mellitus

et al. 2022

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Appropriate dietary intake and physical activity (PA) are essential for glycemic control and optimal growth in youth with type 1 diabetes (T1D). Thus, this study aimed to compare dietary intake and PA between youth with T1D and healthy controls. One hundred Thai youth with T1D and 100 age-matched healthy participants were recruited. A 3-day food record was completed and converted into nutrient intake data. PA data were collected via interview. Participants with T1D had a significantly higher mean ± SD carbohydrate (50.8 ± 6.8% vs. 46.2 ± 7.5%, p < 0.01), lower fat (32.4 ± 5.9% vs. 35.9 ± 6.4%, p < 0.01), and lower protein (16.8 ± 2.6% vs. 17.9 ± 3.5%, p = 0.01) intake compared to controls. Fifty percent of T1D participants and 41% of control participants consumed saturated fat more than recommendations (p = 0.20). Participants with T1D had a higher median (IQR) calcium intake compared to controls (474 (297–700) vs. 328 (167–447) mg/day, p < 0.01). Both groups consumed less fiber and more sodium compared to recommendations. Both groups had inadequate PA. Participants with T1D had significantly less PA compared to controls (25 (13–48) vs. 34 (14–77) minutes/day, p = 0.04). In addition to the need for counseling that promotes consumption of more dietary fiber and calcium and less saturated fat and sodium, the benefits of performing regular exercise need to be emphasized among youth with T1D.

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Effect of gender, diabetes duration, inflammatory cytokines, and vitamin D level on bone mineral density among Thai children and adolescents with type 1 diabetes

Cited by 5 publications

References 61 publications

Higher Body Fat in Children and Adolescents With Type 1 Diabetes–A Systematic Review and Meta-Analysis

Higher Body Fat in Children and Adolescents With Type 1 Diabetes–A Systematic Review and Meta-Analysis

Influence of Tai Chi Softball on Body Composition and Bone Density

Dietary Intake and Physical Activity of Thai Children and Adolescents with Type 1 Diabetes Mellitus

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