Effect of gender-related depression on heart rate variability during an autonomic nervous test

Kuang, Danni; Cui, Liqian; Kuang, Shiyuan; Yang, Rongqian; Chen, Xiuwen; Zhang, Lei; Lv, Ruixue; Ou, Shanxing; Song, Chuanxu

doi:10.1016/j.psychres.2018.12.099

Cited by 16 publications

(12 citation statements)

References 48 publications

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“…Notably, the sex difference in the effect of depression on HRV might be quantitative, but not qualitative, given that there was no significant interaction between diagnosis and sex in the ANOVA analyses (Table S2). In line, Kuang et al 12 also failed to find any significant diagnosis x sex interaction in the effect of depression on HRV at rest. To elucidate the sex difference in the relationship between HRV and depression, further studies in different settings will be required.…”

Section: Discussionmentioning

confidence: 77%

“…Similar to activity indices, some of the HRV indices (RRI, HF, and SDNN) reached the statistical significance only in males but not in females. Previous studies have shown sex differences in HRV; males generally show lower HF and greater LF/HF than females in healthy humans, indicating the predominance of sympathetic modulation in males 11,12 . If depressed patients tend to show lower HF and greater LF/HF, then differences between patients and controls would be smaller in males than in females.…”

Section: Discussionmentioning

confidence: 91%

“…In line with this, a study from Germany, 29 which measured HRV for 30 min in the afternoon while being sedentary in a quiet room, reported that differences in HRV indices between patients with MDD and controls were greater in females than in males, which was the opposite direction to our finding in terms of the sex difference. On the other hand, Kuang et al 12 reported from China that the effect of depression on HRV was different between males and females in deep breathing and Valsalva test, whereas the effect was not different in the resting and orthostatic test. It was reported in Japanese healthy participants that sex differences in HRV measures varied depending on age and time of the day 30 .…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies have shown sex differences in HRV; males generally show lower HF and greater LF/HF than females in healthy humans, indicating the predominance of sympathetic modulation in males. 11,12 If depressed patients tend to show lower HF and greater LF/HF, then differences between patients and controls would be smaller in males than in females. In line with this, a study from Germany, 29 which measured HRV for 30 min in the afternoon while being sedentary in a quiet room, reported that differences in HRV indices between patients with MDD and controls were greater in females than in males, which was the opposite direction to our finding in terms of the sex difference.…”

Section: Discussionmentioning

confidence: 99%

“…11 The power spectral density of HRV in females is characterized by significantly less total power that contains significantly greater high-(HF) and less low-frequency (LF) power. Further, a recent study suggested that the effect of clinical depression on HRV measures is also sex-dependent (eg, Kuang et al 12 ). These findings indicate the importance of sex differences when studying HRV in mood disorders.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous monitoring of activity and heart rate variability in depressed patients: A pilot study using a wearable monitor for 3 consecutive days

Koga

Komatsu

Shinozaki³

et al. 2022

Neuropsychopharm Rep

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Introduction Reduced activity and sleep–wake rhythm disturbances are essential features of depressive episodes. In addition, alterations in heart rate variability (HRV) have been implicated in depression. By using a wearable sensor that monitors 3‐dimensional acceleration and HRV simultaneously, we examined the activity and HRV indices in depressive episode of mood disorders. Methods Participants were 19 patients (13 major depressive disorder [MDD] and 6 bipolar depression; 11 females) and 18 controls (9 females) matched for age and ethnicity (all Japanese) who completed 3 consecutive days of all‐day monitoring by a small and light device attached to the chest. Results Activity magnitude was significantly reduced while lying/resting time was increased in depressed patients, compared with controls. When males and females were examined separately, male, but not female, patients showed significant reduction in activity. HRV indices such as R‐R interval and high‐frequency power (a parameter for the parasympathetic system) were significantly decreased in patients than in controls. Significant differences in activity and HRV indices were seen only in males. Sympathetic load during sleep significantly correlated with damped rest–activity rhythm in depressed patients. Limitations The number of participants was small, and the majority of the participants were taking psychotropic medications. Conclusions We obtained evidence for reduced activity, increased lying/resting time, and reduced HRV indices in male depressed patients. The simultaneous monitoring for activity and HRV suggested greater sympathetic load during sleep is associated with damped rest–activity rhythm (increased activity during sleep and decreased daytime activity), which might be a characteristic pathology of depression.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 91%