2016
DOI: 10.3892/etm.2016.3814
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Effect of general anesthesia on serum β-amyloid protein and regional cerebral oxygen saturation of elderly patients after subtotal gastrectomy

et al.

Abstract: The aim of the present study was to investigate the influence of general anesthesia on serum β-amyloid protein (Aβ) and regional cerebral oxygen saturation (rSO2) of elderly patients after subtotal gastrectomy. From June, 2014 to December, 2015, among 168 patients undergoing subtotal gastrectomy, the Mini-Mental State Examination and Montreal Cognitive Assessment was administered the day prior to surgery and the second and ninth days after the operation. In addition, we administered the tests to 168 healthy ad… Show more

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Cited by 4 publications
(4 citation statements)
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“…Brain Aβ levels can be increased in neurological and psychiatric conditions other than Alzheimer disease (AD), including traumatic brain injury (TBI) [166][167][168][169] , chronic traumatic encephalopathy 170,171 , general anaesthesia [172][173][174][175][176] , cerebral ischaemia [177][178][179][180][181] , major depression [182][183][184] , and amyotrophic lateral sclerosis (AlS) 185,186 . Rapid changes in Aβ levels have been observed in cerebrospinal fluid (CSF) and plasma during cardiac arrest 187 and cardiac surgery 188,189 , even in infants and children 190 , probably owing to combined hypoxia and anaesthetic insult.…”
Section: Promising New Avenuesmentioning
confidence: 99%
“…Brain Aβ levels can be increased in neurological and psychiatric conditions other than Alzheimer disease (AD), including traumatic brain injury (TBI) [166][167][168][169] , chronic traumatic encephalopathy 170,171 , general anaesthesia [172][173][174][175][176] , cerebral ischaemia [177][178][179][180][181] , major depression [182][183][184] , and amyotrophic lateral sclerosis (AlS) 185,186 . Rapid changes in Aβ levels have been observed in cerebrospinal fluid (CSF) and plasma during cardiac arrest 187 and cardiac surgery 188,189 , even in infants and children 190 , probably owing to combined hypoxia and anaesthetic insult.…”
Section: Promising New Avenuesmentioning
confidence: 99%
“…Therefore, the combined expression of Aβ and rSO 2 can be used as a diagnostic and predictive indicator of POCD post-subtotal gastrectomy in older patients. 75 These results suggest a correlation between changes in rSO 2 and POCD during abdominal surgery. However, further investigations are needed to confirm this hypothesis.…”
Section: Association Of Cerebral Oxygen Saturation With Pocd In Diffe...mentioning
confidence: 66%
“…Combined expression of Aβ and rSO 2 can be used as a diagnostic and predictive indicator of POCD. [ 75 ] 2016 Abbreviations : POCD, postoperative cognitive dysfunction; rSO2, regional cerebral oxygen saturation; rScO2, regional cerebral oxygen saturation; SctO2, cerebral tissue oxygen saturation; …”
Section: Association Of Cerebral Oxygen Saturation With Pocd In Diffe...mentioning
confidence: 99%
“…There were no significant differences detected in H 2 concentrations of the two tissues after inhaling low or high concentrations of H 2 . The cerebral blood mainly comes from the carotid arterial, and its blood flow accounts for about 15% of the total cardiac output ( Yu et al., 2016 ). As of now, several studies have explored the H 2 concentration in arterial blood after H 2 inhalation.…”
Section: Discussionmentioning
confidence: 99%