Effect of genetic polymorphisms on smoking cessation: a trial of bupropion in Korean male smokers

Han, Doug-Hyun; Joe, Keun Ho; Na, Chul; Lee, Young-Sik

doi:10.1097/ypg.0b013e3282df0939

Cited by 31 publications

(48 citation statements)

References 26 publications

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“…One study found no association between COMT genotype and smoking intensity (David et al 2002, McKinney et al 2000, whereas another found the GG genotype to be associated with smoking at least one pack per day (Tochigi et al 2007). In studies that examined COMT in relation to smoking abstinence in randomized treatment trials of smoking cessation, observations have varied from no association (Ton et al 2007), to the AG/GG genotypes being associated with quicker relapse (Munafo et al 2008), to the GG genotype being associated with smoking abstinence (Han et al 2008). In another study, the G allele was observed to be protective against nicotine dependence (Beuten et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Higher DBH plasma concentrations may influence drug dependence (Cubells et al 2000, Gabel et al 1995. However, so far the evidence concerning variants in the COMT, DBH and MAO-A genes in relation to smoking behaviors has been inconsistent (Beuten et al 2006, Colilla et al 2005, David et al 2002, Enoch et al 2006, Guo et al 2007, Han et al 2008, Jin et al 2005, Johnstone et al 2004, McKinney et al 2000, Munafo et al 2008, Tochigi et al 2007, Ton et al 2007). …”

Section: Catechol-o-methlyltransferase (Comt) Dopamine Beta-hydroxylmentioning

confidence: 99%

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A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A)

Shiels

Huang

Hoffman

et al. 2008

Preventive Medicine

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Objective-Cigarette smoking behavior may be influenced by catechol-O-methlyltransferase (COMT), dopamine beta-hydroxylase (DBH), and monamine oxidase-A (MAO-A), genes that play roles in dopamine metabolism. The association between common polymorphisms of these genes and smoking behavior was assessed among 10,059 Caucasian volunteers in Washington County, MD in 1989.Methods-Age-adjusted logistic regression was used to measure the association between variants of these single nucleotide polymorphisms and smoking initiation and persistent smoking.Results-Overall, no association was seen between each genotype and smoking behavior. However, among younger (<54 years) women, the COMT GG genotype was positively associated with smoking initiation (OR=1.3; 95% CI: 1.1, 1.5), and the MAO-A TT genotype was inversely associated with persistent smoking (OR=0.5; 95% CI: 0.3, 0.9). Men who smoked fewer than 10 cigarettes per day were more likely to be persistent smokers if they had the COMT GG (OR=1.7; 95% CI: 1.0, 2.9) or the DBH GG (OR=1.6; 95% CI: 1.0, 2.6) genotypes.Conclusion-Overall the results of this large community-based study do not provide evidence to support the presence of important associations between variants of COMT, DBH, or MAO-A and smoking initiation or persistent smoking.

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Section: Discussionmentioning

confidence: 99%

Section: Catechol-o-methlyltransferase (Comt) Dopamine Beta-hydroxylmentioning

confidence: 99%

A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A)

Shiels

Huang

Hoffman

et al. 2008

Preventive Medicine

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“…However, Swan et al [2005] observed these effects only in women. Nevertheless, Han et al [2008] reported that smokers having both homozygote genotypes (A1/A1 or A2/A2) had higher abstinence rates than heterozygotes (A1/A2).…”

Section: Bupropionmentioning

confidence: 94%

“…The single study analyzing association between DRD4 exon III 48-bp VNTR genotypes and smoking cessation following bupropion therapy found no significant results [Han et al, 2008]. There was also no association between 5-HTTLPR genotypes and response to bupropion treatment [Han et al, 2008].…”

Section: Bupropionmentioning

confidence: 96%

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Pharmacogenetics of smoking cessation therapy

Kortmann

Dobler

Bizarro

et al. 2009

American J of Med Genetics Pt B

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Nicotine dependence is a major health problem, with a large amount of smoking-related premature deaths and disabilities. The dependence mechanism of nicotine is especially complex and is under strong genetic influence. Smoking cessation is associated with substantial health benefits. Evidence from animal and human studies suggests that genetic polymorphisms influencing pharmacokinetics and pharmacodynamics of nicotine may have great potential for aiding smoking treatment. There are more than 30 association studies and one genome-wide association study (GWAS) between genetic polymorphisms and smoking cessation following nicotine replacement therapy (NRT) and/or bupropion therapy. However, only a few candidate genes or regions were analyzed more than twice and even these genes require additional investigations in different therapeutic schemes. There are a growing number of new pharmacologic options that have not been pharmacogenetically assessed according to published literature. In addition, molecular genetics studies are needed to assess the functional mechanisms of some putative association results. Taken together, the preliminary findings are promising but raise the need for new studies with adequate sample sizes and adjustment for several potential confounding factors frequently neglected, such as comorbidity and sociodemographic factors. The current state of the art in the field encourages an optimist view that personalized treatment approaches may become possible. However, the current scientific evidence still does not support the use of pharmacogenetic tests in routine smoking cessation therapy.

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Genetic linkage findings for DSM‐IV nicotine withdrawal in two populations

Pergadia

Agrawal

Loukola

et al. 2009

American J of Med Genetics Pt B

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Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability= 45%). Only one previous linkage study has published findings on NW (Swan et al., 2006; LOD=2.7; Chr. 6 at 159 cM). As part of an international consortium, genome-wide scans (using 381 autosomal microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N=450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores greater than 1.5 were found on two chromosomes: 6 (FIN: LOD= 1.93 at 75 cM) and 11 at two different locations (FIN: LOD= 3.55 at 17 cM, and AUS: LOD= 1.68 with a COMB: LOD= 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (p = .013 with 1000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for nicotine withdrawal.

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Effect of genetic polymorphisms on smoking cessation: a trial of bupropion in Korean male smokers

Abstract: It can be concluded that genetic diversity might determine the effects of bupropion on smoking cessation.

Cited by 31 publications

References 26 publications

A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A)

A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A)

Pharmacogenetics of smoking cessation therapy

Genetic linkage findings for DSM‐IV nicotine withdrawal in two populations

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