Effect of genetically determined BCAA levels on cardiovascular diseases and their risk factors: A Mendelian randomization study

Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to the Development of Hypertension and Coronary Heart Disease

“…7 Total branchedchain amino acids (tBCAAs), glycine, glutamine, histidine, and alanine, demonstrated associations with altered blood pressure (BP) and cardiometabolic diseases. 8,9 This suggests that amino acids might modulate biochemical pathways of BP regulation. [8][9][10][11][12] Mendelian randomization (MR) analysis, which utilizes genetic variations as instrumental variables (IVs), may deliver additional evidence on the cause-and-effect relationship between specific exposures and clinical outcomes in the field of cardiovascular disease research.…”

“…8,9 This suggests that amino acids might modulate biochemical pathways of BP regulation. [8][9][10][11][12] Mendelian randomization (MR) analysis, which utilizes genetic variations as instrumental variables (IVs), may deliver additional evidence on the cause-and-effect relationship between specific exposures and clinical outcomes in the field of cardiovascular disease research. [13][14][15] Using MR analysis and phase 1 nuclear magnetic resonance metabolomics data from the UK Biobank, as well as data from the metabolomic study of Kettunen et al, 16 Lin et al 8 demonstrated that the level of glycine and BCAAs, being a pool of highly correlated valine, leucine, and isoleucine, may potentially causally associate with BP level and hypertension development, yet with the opposite direction of the effect.…”