Effect of gentamicin on lipid peroxidation in rat renal cortex

Ramsammy, Leslie S.; Ling, Kit‐Yin; Josepovitz, Christine; Levine, R; Kaloyanides, George J.

doi:10.1016/0006-2952(85)90441-1

Cited by 64 publications

(26 citation statements)

References 31 publications

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“…GM nephrotoxicity is, at least partially, attributed to the generation of free radicals, enhanced lipid peroxidation, and decreased glutathione (GSH), in the kidney (Ramsammy et al, 1985;Walker & Shah, 1988;Ali et al, 1992). It is reasonable, therefore, to suggest that the observed nephroprotective action of the date flesh and pits may be due to an increase in activity of the free radical scavenging enzymes or counteraction of the free radicals.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Action ofPhoenix dactylifera. in Gentamicin-Induced Nephrotoxicity

Alqarawi

Abdel-Rahman

Mousa

et al. 2008

Pharmaceutical Biology

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We investigated the effect of an extract of the flesh and pits of dates [Phoenix dactylifera L (Arecaceae or Palmae)] on gentamicin (GM) nephrotoxicity in rats. The animals were given either the date flesh extract mixed with the food (50% w/w) or the pits extract mixed in the drinking water (2:1 w/v), and GM (80 mg kg −1 day −1 intramuscularly for 6 days) was injected during the last 6 days of treatment. Other groups of rats were given GM concomitantly with the date flesh extract or the date pits extract at the above doses. GM treatment significantly increased the plasma concentrations of creatinine and urea and induced a marked necrosis of the renal proximal tubules. The date flesh and pits were effective in significantly reducing the increases in plasma creatinine and urea concentrations induced by GM nephrotoxicity and ameliorating the proximal tubular damage. Antioxidant components in the date (e.g., melatonin, vitamin E, and ascorbic acid) were suggested to be the basis of the nephroprotection.

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Section: Discussionmentioning

confidence: 99%

Nephroprotective Action ofPhoenix dactylifera. in Gentamicin-Induced Nephrotoxicity

Alqarawi

Abdel-Rahman

Mousa

et al. 2008

Pharmaceutical Biology

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“…[27][28][29] Several reports have documented the pathogenesis of aminoglycoside-induced renal tubular cell injury such as derangement of lysosomal, mitochondrial and plasma membrane structure. [30][31][32] Furthermore, results of many studies have shown that the altered concentrations of various biochemical indicators of oxidative stress in kidney tissue are due to GEN. [33][34][35] Because of the obvious responsibility of ROS in GEN induced renal damage, several antioxidant agents have been used to block GEN nephrotoxicity. [36][37][38] In this study, we used a polyphenolic compound RSV, which was able to increase antioxidant capacity.…”

Section: Discussionmentioning

confidence: 99%

Gentamicin-Induced Nephrotoxicity in Rats Ameliorated and Healing Effects of Resveratrol

Silan¹,

Uzun²,

Çomunoglu

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Moreover, it has been reported that a marked increase in phosphatidylinositol and PC concentrations in kidney tissue may be observed after GM administration [24, 25]. The SPH/PC ratio is known to serve as one of the major indices of membrane fluidity [26, 27, 28].…”

Section: Discussionmentioning

confidence: 99%

Biochemical Renal Manifestations Induced by Consecutive Administration of Gentamicin in Rats

Soejima

Ishizuka²,

Suzuki³

et al. 1998

Nephron

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In the present study, we investigated the generation of lipid peroxides and changes in total phospholipid levels in the kidney tissue of rats with acquired resistance to gentamicin (GM). GM resistance was induced in Sprague-Dawley male rats by subcutaneously administering each rat a dose of 80 mg/kg/day of GM for 40 consecutive days. Twelve days after the GM administration, serum urea nitrogen peaked at 35 mg/dl. The urinary creatinine excretion progressively decreased, beginning 4 days after the start of GM administration. The fractional excretion of sodium progressively increased, beginning 4 days after the start of GM administration, peaking on the 10th day. However, despite the continuation of GM administration, the urinary creatinine excretion gradually increased, and the serum urea nitrogen concentrations recovered to previous levels after 21 days. We also analyzed the relationship between the acquired resistance to GM and changes in the reduced glutathione content and glutathione peroxidase activity. Simultaneously, we investigated sequential changes in the activities of phospholipase A₂ and phospholipase C, which release peroxidized membrane phospholipids into the cytoplasm via hydrolysis, as well as the relationship between changes in the kidney tissue phospholipid composition (sphingomyelin/phosphatidylcholine ratio) and renal function. We found that (1) the kidney tissue glutathione content rapidly decreased after GM administration before subsequently increasing and being maintained at a higher level; (2) the glutathione peroxidase activity showed a persistent decrease after GM administration; (3) the kidney tissue phospholipase A₂ activity decreased after GM administration, while the phospholipase C activity exhibited a sustained increase from 21 days, and (4) the spingomyelin/phosphatidylcholine ratio decreased on the 4th day before stabilizing when acquired resistance was obtained. Based on these findings, we conclude that an increased supply of reduced glutathione and the induction of an antioxidase, substituting for glutathione peroxidase, may play a significant role in the acquisition of resistance to acute renal failure which occurs with continuous GM administration. Improved membrane fluidity, achieved by maintenance of the membrane phospholipid composition by increased phospholipase C activity, may be an additional factor contributing to the recovery of the renal function.

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Effect of gentamicin on lipid peroxidation in rat renal cortex

Cited by 64 publications

References 31 publications

Nephroprotective Action ofPhoenix dactylifera. in Gentamicin-Induced Nephrotoxicity

Nephroprotective Action ofPhoenix dactylifera. in Gentamicin-Induced Nephrotoxicity

Gentamicin-Induced Nephrotoxicity in Rats Ameliorated and Healing Effects of Resveratrol

Biochemical Renal Manifestations Induced by Consecutive Administration of Gentamicin in Rats

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