Effect of gentamicin on serum digoxin level in patients with congestive heart failure

Alkadi, Hussien O.; Nooman, Majed Alwan; Raja'a, Yahia A.

doi:10.1023/b:phar.0000018594.26809.87

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…Previous studies have shown that glycopeptide antibiotics, including vancomycin and teicoplanin, as well as broad spectrum β-lactam antibiotics such as cefepime and dihydrostreptomycin can be used as adjunctive gentamicin antibiotics in the treatment process . Other studies have shown that digoxin is widely used for treatment of heart failure, while gentamicin is often used to prevent bacterial infections in heart failure patients . To evaluate specificity, we tested the drugs mentioned above (1 μM) that may be simultaneously used with gentamicin in clinical therapy (except for neomycin).…”

Section: Resultsmentioning

confidence: 99%

“…48 Other studies have shown that digoxin is widely used for treatment of heart failure, while gentamicin is often used to prevent bacterial infections in heart failure patients. 49 To evaluate specificity, we tested the drugs mentioned above (1 μM) that may be simultaneously used with gentamicin in clinical therapy (except for neomycin). The results of the specificity test demonstrate that the PaMscS1 nanopore is not disturbed by these drugs.…”

Section: Resultsmentioning

confidence: 99%

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Direct and Continuous Monitoring of Multicomponent Antibiotic Gentamicin in Blood at Single-Molecule Resolution

Zhao,

Wang,

Chen

et al. 2024

ACS Nano

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Point-of-care monitoring of small molecules in biofluids is crucial for clinical diagnosis and treatment. However, the inherent low degree of recognition of small molecules and the complex composition of biofluids present significant obstacles for current detection technologies. Although nanopore sensing excels in the analysis of small molecules, the direct detection of small molecules in complex biofluids remains a challenge. In this study, we present a method for sensing the small molecule drug gentamicin in whole blood based on the mechanosensitive channel of small conductance in Pseudomonas aeruginosa (PaMscS) nanopore. PaMscS can directly detect gentamicin and distinguish its main components with only a monomethyl difference. The 'molecular sieve' structure of PaMscS enables the direct measurement of gentamicin in human whole blood within 10 min. Furthermore, a continuous monitoring device constructed based on PaMscS achieved continuous monitoring of gentamicin in live rats for approximately 2.5 h without blood consumption, while the drug components can be analyzed in situ. This approach enables rapid and convenient drug monitoring with single-molecule level resolution, which can significantly lower the threshold for drug concentration monitoring and promote more efficient drug use. Moreover, this work also lays the foundation for the future development of continuous monitoring technology with single-molecule level resolution in the living body.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Direct and Continuous Monitoring of Multicomponent Antibiotic Gentamicin in Blood at Single-Molecule Resolution

Zhao,

Wang,

Chen

et al. 2024

ACS Nano

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“…, 1985). Gentamycin can induce a significant increase in serum digoxin level of diabetic patients and patients with congestive heart failure (Alkadi, Nooman & Raja'a, 2004). Carvedilol also increases serum concentrations of digoxin in children (Ratnapalan, Griffiths, Costei, Benson & Koren, 2003).…”

Section: Clinical Studiesmentioning

confidence: 99%

Cardiotoxicity of digitalis glycosides: roles of autonomic pathways, autacoids and ion channels

Demiryürek

2005

Auton Autocoid Pharmacol

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1 Cardiac glycosides have been used for centuries as therapeutic agents for the treatment of heart diseases. In patients with heart failure, digoxin and the other glycosides exert their positive inotropic effect by inhibiting Na(+)-K(+)-ATPase, thereby increasing intracellular sodium, which, in turn, inhibits the Na(+)/Ca(2+) exchanger and increases intracellular calcium levels. As the therapeutic index of digitalis is narrow, arrhythmias are common problems in clinical practice. The mechanisms and mediators of these arrhythmias, however, are not completely understood. 2 The involvement of the sympathetic and parasympathetic nervous system in digitalis cardiac toxicity is reviewed. 3 Receptors, channels, exchange systems or other cellular components involved in digitalis-induced cardiotoxicity are also reviewed. 4 Possible mediators of digitalis-induced cardiac toxicity are discussed. 5 Management of digitalis toxicity in patients is summarized. 6 The determination of the possible mediators of digitalis-induced cardiac toxicity will enhance our knowledge and lead to the development of new therapeutic strategies to treat these lethal arrhythmias.

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Challenges in Therapeutic Drug Monitoring of Digoxin Using Immunoassays

Dasgupta

2012

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring

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Effect of gentamicin on serum digoxin level in patients with congestive heart failure

Abstract: The present study indicated that increase serum digoxin level when combined with gentamicin should be considered a risk factor for digitalis toxicity.

Cited by 6 publications

References 4 publications

Direct and Continuous Monitoring of Multicomponent Antibiotic Gentamicin in Blood at Single-Molecule Resolution

Direct and Continuous Monitoring of Multicomponent Antibiotic Gentamicin in Blood at Single-Molecule Resolution

Cardiotoxicity of digitalis glycosides: roles of autonomic pathways, autacoids and ion channels

Challenges in Therapeutic Drug Monitoring of Digoxin Using Immunoassays

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