Effect of Gentiana Violet against Methicillin-Resistant Staphylococcus aureus (MRSA)

Saji, Mamoru

doi:10.11150/kansenshogakuzasshi1970.66.914

Cited by 20 publications

(11 citation statements)

References 2 publications

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“…On the other hand, the observed necrotic lesions might not have been caused by the highdose steroid therapy, given that a similar lesion developed prior to steroid therapy in case 5, and reappeared in case 4 during a 5-mg daily dose of prednisolone. The present study confirmed the previously reported finding that topical bactericidal reagent gentiana violet reduces the risk of local infection with methicillin-resistant Staphylococcus aureus, 6 and further found that it accelerated the healing of the skin, as in case 4. Thus, strict sterilization is considered to be essential for treatment of this type of lesion.…”

Section: Discussionsupporting

confidence: 92%

Dermatomyositis and cutaneous necrosis: report of five cases

Nara

Kano

Masuyama

et al. 2000

Modern Rheumatology

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We report on five patients with dermatomyositis (DM) and cutaneous necrosis. Patients presented with classic DM skin eruptions, mild myositis, and a high incidence (4/5) of interstitial pneumonia. Cutaneous necrosis developed independently of steroid therapy, with the majority of lesions being cured following several months of sterilization treatment. In addition, one patient with accompanying cancer presented with multiple necrotic lesions. Topical treatment using gentiana violet against local infection was considered to have been essential in accelerating healing.

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Section: Discussionsupporting

confidence: 92%

Dermatomyositis and cutaneous necrosis: report of five cases

Nara

Kano

Masuyama

et al. 2000

Modern Rheumatology

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“…Recent laboratory data have suggested that gentian violet may be efficient against MRSA 5 . In addition, eradication of MRSA from decubitus ulcers with gentian violet has been reported 6 …”

Section: Discussionmentioning

confidence: 99%

Topical gentian violet for cutaneous infection and nasal carriage with MRSA

Okano¹,

Noguchi²,

Tabata³

et al. 2000

Int J Dermatology

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This study describes a potential effect of topical gentian violet on cutaneous infection and nasal carriage with methicillin-resistant Staphylococcus aureus (MRSA). 0.5% gentian violet was used in 28 cases of skin lesions once a day, while a 0.3% solution was applied on the nasal vestibules of nine cases twice a day. The period for eradication in the 28 skin cases was 9.1 +/- 6.0 days. It was 15.3 +/- 9.0 days for the nine nasal lesions. The minimal inhibitory concentration (MIC) of gentian violet against MRSA from the four isolated strains was 0.0225 +/- 0.0096 microg/mL. No adverse reactions occurred throughout the study. It is suggested that gentian violet may be potentially effective against MRSA.

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“…Recently, it has been attracting attention as a local therapeutic agent for methicillin‐resistant Staphylococcus aureus . Therefore, in regard to carcinogenensis and toxicity, there may be no problem in terms of safety when crystal violet is used 22,23 …”

Section: Practice Of Pit Observation By Magnifying Endoscopymentioning

confidence: 99%

“…Therefore, in regard to carcinogenensis and toxicity, there may be no problem in terms of safety when crystal violet is used. 22,23 Digestive Endoscopy (2001) 13 (Suppl. ), S10-S13…”

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confidence: 99%

Diagnosis of invasive depth by pit pattern in early colorectal cancer using magnifying endoscopy

Takahashi

2001

Digestive Endoscopy

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Model and function of the magnifying endoscopeMagnifying endoscopes (CF-200Z, PCF-Q240ZI, CF-Q240ZL/I; manufactured by Olympus, Tokyo, Japan) are applicable for 80-100 times magnified observation. Using CF-200Z and PCF-Q240ZI, magnification is controlled by manual strokes, but CF-Q240ZL/I is equipped with an electronic zoom, and the magnification can be controlled by the easy operation of a hand or foot switch. Practice and safety of magnified observation by dye spraying methodsIn the dye contrast method, 0.1-0.4% indigocarmine dye is sprayed over the lesion, and the pattern of indigocarmine dye that is retained in the crypt is recognized as the pit. However, indigocarmine dye is not well-retained in pits smaller than the normal pit, and type IIIs and small type V glands cannot be observed in this way. 20 In the dye staining method, the nuclei and cytoplasm of intestinal tract surface epithelial cells are stained by applying 0.05-0.1% crystal violet to the lesion, and observing the pattern of non-stained crypt as a pit. 20 Although it is not clear whether the pit observed is formed by staining of the nuclei or cytoplasm, the fact that the border observed differs between the contrast and staining methods suggests that a pit formed by the staining method is formed by nuclear staining (Fig. 2a,b). Crystal violet (methylrosanilinium chloride) was synthesized as a triphenylmethanaminium dye around 1860. It is a selective bactericidal agent that was used for the treatment of gram-positive bacteria by Stilling et al. 21 in 1890. In 1930, Faust used it as an anthelminthic for stercoral strongyloides, and it was used as an anthelminthic for oxyuris vermicularis in 1940. It is not currently used for the treatment of parasites, but rather as a bactericidal disinfectant. 21 Recently, it has been attracting attention as a local therapeutic agent for methicillin-resistant Staphylococcus aureus. Therefore, in regard to carcinogenensis and toxicity, there may be no problem in terms of safety when crystal violet is used. 22,23 Digestive Endoscopy (2001) 13 (Suppl.), S10-S13 SESSION 1, PART 1: MODERATOR'S COMMENT

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Effect of Gentiana Violet against Methicillin-Resistant Staphylococcus aureus (MRSA)

Cited by 20 publications

References 2 publications

Dermatomyositis and cutaneous necrosis: report of five cases

Dermatomyositis and cutaneous necrosis: report of five cases

Topical gentian violet for cutaneous infection and nasal carriage with MRSA

Diagnosis of invasive depth by pit pattern in early colorectal cancer using magnifying endoscopy

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