Effect of GH p.L127V Polymorphism and Feeding Systems on Milk Production Traits and Fatty Acid Composition in Modicana Cows

Bordonaro, Salvatore; Tumino, Serena; Marletta, Donata; Angelis, Anna De; Paola, Fortunato Di; Avondo, Marcella; Valenti, Bernardo

doi:10.3390/ani10091651

Cited by 12 publications

(6 citation statements)

References 44 publications

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“…Recently, the study of the polymorphism has been used to optimize the performance and composition of dairy cows [ 25 , 26 , 27 , 28 ]. The GWAS data in Li and his colleagues’ study suggested that a SNP in the SORBS 1 gene can significantly influence the composition of fatty acids in milk, especially MUFAs and PUFAs [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of SORBS1 Gene and Their Correlation with Milk Fat Traits of Cattleyak

Yang

Min

Zhu

et al. 2021

Animals

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This study aimed to find the SNPs in the SORBS1 gene of cattleyak, analyze the relationship between its polymorphisms and the milk fat traits, and find potential molecular markers for the milk fat traits of cattleyak. The polymorphism of the SORBS1 gene in 350 cattleyak from Hongyuan County (Sichuan, China) were detected by PCR and DNA sequencing, and the correlation between these SNPs and the milk production traits of cattleyak was analyzed. The results showed that there were nine SNPs in the CDS and their adjacent non-coding regions of the SORBS1 gene, and all SNPs have three genotypes. The correlation analysis found that the genotypes with superior milk fat traits in the other eight alleles were homozygous genotypes with a high genotype frequency except the g.96284 G > A (c.3090 G > A) (p < 0.05). However, at locus g.96284 G > A, the milk fat percentage, monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) of the GA genotype were significantly higher than that of GG and AA genotypes (p < 0.05). Among these SNPs, three SNPs (g.6256 C > T (c.298 C > T), g.24791 A > G (c.706 A > G) and g.29121 A > G (c.979 A > G)) caused the amino acids change. The genotypes of the three SNPs consist of three haplotypes and four diplotypes. The amino acid mutation degree of diplotype H1–H1 (CCAAAA) was the highest, and its milk fat percentage, MUFAs, PUFAs and SFAs were also the highest (p < 0.05). Taken together, we found nine SNPs in the SORBS1 gene that are closely related to the milk fat traits of cattleyak. Moreover, the mutation of amino acids caused by SNPs had positive effects on the milk fat traits of cattleyak. H1-H1 is the dominant diplotype which significantly related to the milk fat traits of cattleyak. This study provides a new molecular marker and theoretical basis for screening the milk fat traits of cattleyak.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of SORBS1 Gene and Their Correlation with Milk Fat Traits of Cattleyak

Yang

Min

Zhu

et al. 2021

Animals

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“…Modicana cows are usually reared in extensive systems, using pasture during the grazing season and with limited or no supplementation of concentrate. Semi-intensive farming systems are also possible when animals cannot go to pasture and need higher concentrate supplementation [ 3 , 4 ]. Feeding has an important role in determining most milk quality traits such as fat content and fatty acid composition [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Breed and Feeding System Impact the Bioactive Anti-Inflammatory Properties of Bovine Milk

Salzano

Meo

Bifulco

et al. 2022

IJMS

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In the present study, we aimed at assessing the influence of breed and feeding system on the bovine milk profile of betaines and carnitines and milk capacity in counteracting the inflammatory endothelial cell (EC) damage induced by interleukin (IL)-6. In the first experimental design, two breeds were chosen (Holstein vs. Modicana) to investigate the biomolecule content and antioxidant capacity in milk and dairy products. In the second experimental design, two feeding systems (pasture vs. total mixed ratio) were tested only in Holstein to evaluate the possible effect on the functional profile of milk and dairy products. Finally, the bulk milk from the two experimental designs was used to evaluate the efficacy of preventing IL-6-induced endothelial inflammatory damage. Results showed that Modicana milk and whey had higher biomolecule content and antioxidant activity compared to Holstein milk (p < 0.01). Milk from Holstein fed TMR showed higher concentration of γ-butyrobetaine, δ-valerobetaine (p < 0.01), and l-carnitine (p < 0.05). Similarly, whey from Holstein fed TMR also showed higher content of δ-valerobetaine, glycine betaine, l-carnitine, and acetyl-l-carnitine (p < 0.01) compared to the Holstein fed pasture. Conversely, the antioxidant activity of milk and dairy products was not affected by the feeding system. In ECs, all milk samples reduced the IL-6-induced cytokine release, as well as the accumulation of reactive oxygen species (ROS) and the induction of cell death, with the most robust effect elicited by Modicana milk (p < 0.01). Overall, Modicana milk showed a higher content of biomolecules and antioxidant activity compared to Holstein, suggesting that the breed, more than the feeding system, can positively affect the health-promoting profile of dairy cattle milk.

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“…GH is considered a candidate gene associated with growth, milk and reproduction traits (Curi et al, 2006;Dario et al, 2005;Grochowska et al, 2001;Pereira et al, 2005;Sönmez et al, 2018). Researchers have identified several polymorphisms in the GH gene (Amiri et al, 2018;Bordonaro et al, 2020). The best-known polymorphisms are the missense mutation C>G in exon five that changes leucine (L) to valine (V) in position 127, which can be characterized using the AluI restriction enzyme (Hradecka et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the association between Growth Hormone (GH) gene polymorphism and growth traits in cattle breeds

Bayraktar

Özdemir²

2022

J Hellenic Vet Med Soc

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GH gene is one of the important genes that affect the productive and physiological traits in livestock. This study aimed to use a meta-analysis to determine the association of the GH gene with growth traits in cattle. Four different genetic models were used: dominant LL + LV versus VV, recessive LL versus LV + VV, complete over dominant LL+VV vs. LV and co-dominant LL vs. LV, LL vs. VV and LV vs. VV. The random-effect model was used in data analysis based on I2. Meta-analysis showed an effect of GH genotypes on the birth weight (BW) under the recessive (p<0.05) and complete over dominant (p<0.01) models. However, no association (p>0.05) was found under the dominant model. In terms of co-dominant model, the GH polymorphism showed a significant association with BW (SMD = 0.359, 95% CI = 0.119 to 0.599, p = 0.003) under LL vs. LV genotype combination patterns. No association was found between GH polymorphism and BW under LL vs. VV genotype combination. The results showed that the LL genotype had a significant effect on BW traits from LV and VV genotypes when comparing the models. The results showed an effect of the GH on ADG under four genetic models (p<0.05).

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Effect of GH p.L127V Polymorphism and Feeding Systems on Milk Production Traits and Fatty Acid Composition in Modicana Cows

Cited by 12 publications

References 44 publications

Polymorphisms of SORBS1 Gene and Their Correlation with Milk Fat Traits of Cattleyak

Polymorphisms of SORBS1 Gene and Their Correlation with Milk Fat Traits of Cattleyak

Breed and Feeding System Impact the Bioactive Anti-Inflammatory Properties of Bovine Milk

A meta-analysis of the association between Growth Hormone (GH) gene polymorphism and growth traits in cattle breeds

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