Effect of ginger (<i>Zingiber officinale</i>) on semen quality

Banihani, Saleem Ali

doi:10.1111/and.13296

Cited by 23 publications

(23 citation statements)

References 65 publications

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“…Other mechanisms include increasing testicular weight, increasing blood flow to the testes and recycling testosterone receptors. Accordingly, the positive impact of ginger on sperm parameters, and thus on semen quality, may be attributable, at least in part, to the increased levels of gonadal hormones (testosterone and luteinising hormone; Banihani, 2019).…”

Section: Resultsmentioning

confidence: 99%

A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans

Gholami‐Ahangaran

Karimi-Dehkordi

Javar

et al. 2021

Veterinary Medicine & Sci

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There is an evidence that ginger enhance semen quality via improving different sperm parameters mainly count, viability, motility, morphology and DNA integrity. According to research results in various species, ginger seems to have strong antioxidant properties (due to the presence of active phenolic compounds) and androgenic activity. Ginger improves semen quality and increases fertility of sperm by disrupting the production of free radicals, dissolving oxidative chain reactions, reducing oxidative stress and altering the levels of gonadotropin hormones (LH, FSH) and sex hormones (such as testosterone). The antioxidant and androgenic properties of ginger give a sperm with normal morphological structure (head, middle and tail) and more integrated chromatin. The rate of DNA failure and damage to the mitochondrial genome in these cells is minimal and they have the most progressive motility, the highest viability and the best fertility. Therefore, the use of the ginger significantly improves the biological parameters of sperm (number, total motility, survival rate and normal morphology) and also increases all specialized fertility indicators of sperm. Tacking account of lacking literature and possibility of toxicity and adverse effect of ginger on vital organ, further clinical trial especially on evaluating the safety and clinical effect must be considered. Also, dose and duration of consumption by monitoring of health indicators and biochemical changes in all species such as human, animal and poultry must be applied.

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Section: Resultsmentioning

confidence: 99%

A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans

Gholami‐Ahangaran

Karimi-Dehkordi

Javar

et al. 2021

Veterinary Medicine & Sci

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“…However, there were no statistically important differences for spermatozoa parameters (count and motility) between the study groups. Besides, no side effects were reported by patients (Hosseini et al, 2016;Gholamnezhad et al, 2018;Banihani, 2019).…”

Section: Clinical Studiesmentioning

confidence: 85%

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

et al. 2021

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Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

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“…Moreover, a study recruited thirty‐six subjects who used 300 mg of aspirin, for 2 months, found that the level of H 2 O 2 increased significantly after one month of use of aspirin (Bouzenna et al, ). Given that one major cause of reduced sperm function is ROS build‐up and formation of oxidative stress (Aitken, Smith, Jobling, Baker, & Iuliis, ; Banihani, , ; Bisht, Faiq, Tolahunase, & Dada, ), which disrupts the integrity of sperm DNA and damages the lipids and proteins in sperm plasma membrane (Ali Banihani & Al‐Khawalde, ; Barati, Nikzad, & Karimian, ; Wright, Milne, & Leeson, ), then, based on the above evidence, it can be suggested that aspirin affects negatively sperm function by inducing oxidative stress.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

Effect of aspirin on semen quality: A review

Banihani

2019

Andrologia

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According to the PubMed data base, there are at least fifty published articles that link between aspirin and semen quality. However, such link has yet to be comprehensively discussed and summarised. This work reviews and summarises the effect of aspirin on semen quality and sperm fertility characteristics, and hence on semen fertilising ability. To achieve this contribution, an electronic search of PubMed and Scopus databases was conducted for original manuscripts, presented from January 1974 through September 2019, via the keywords “aspirin” and “acetylsalicylic acid” versus “sperm” and “semen.” In summary, there is a scientific research consensus that reveals negative effects of aspirin on semen quality. Still, clinical studies that directly examine the effect of aspirin on the main semen quality parameters are needed to support this conclusion. Mechanistically, the negative documented effect of aspirin on semen quality parameters may be attributable to decreased synthesis of testosterone, reduced function of nuclear factor kappa‐light‐chain‐enhancer of activated B cells, decreased formation of testicular prostaglandins, reduced production of seminal nitric oxide and increased oxidative injury to sperm.

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Effect of ginger (Zingiber officinale) on semen quality

Cited by 23 publications

References 65 publications

A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans

A systematic review on the effect of Ginger (Zingiber officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Effect of aspirin on semen quality: A review

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