Effect of Ginkgo biloba extract on endotoxin-induced labyrinthitis

Jang, Chul Ho; Cho, Yong Bum; Kim, Jun Sung; Cho, Sung Woo; Yang, Hyung Chae; Jung, Kee Hong; Kim, Jae Young; Choi, Choong Hyeok; Lim, Yong Gul; Park, Haekyun; Kang, Sung In

doi:10.1016/j.ijporl.2011.04.003

“…It acts as an antioxidant and has been shown to significantly reduce GM-induced NO production in cochlear cultures [16,17,24] . Our previous report showed that GBE significantly minimizes cochlear damage against endotoxin-induced otitis media with labyrinthitis in a guinea pig model [28] . In the present study, GM-induced NO production was reduced by GBE treatment, and the surface structure was protected.…”

Section: Discussionmentioning

confidence: 93%

Protective Effect of Ginkgo Biloba Extract on Gentamicin-Induced Structural Changes of Calcite-Gelatin Composite

Jang

¹

,

Cho²,

Lee³

2016

Int Adv Otol

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OBJECTIVE:To evaluate the protective effect of Ginkgo biloba extract (GBE) on gentamicin (GM)-induced morphological damage of an artificial otoconia. MATERIALS and METHODS:An artificial otoconia powder was placed in a 12-well culture plate containing artificial endolymph. GM (500 μL; 40 mg/mL) was added to the first four wells. GM (500 μL; 40 mg/mL) with GBE (500 μL) was added to the next four wells. PBS (500 μL) was added to the remaining four wells as a control. The levels of nitric oxide (NO) synthesis were determined in the supernatants of each group. Alteration in surface morphology and calcium content were determined by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX), respectively. RESULTS:NO concentration increased in the GM-treated group compared with that in the control group. When the calcite-gelatin composite was treated with GBE, GM-stimulated NO production significantly decreased. The surface of the calcite-gelatin composite exposed to GM showed erosive fissures and had a honeycomb-like appearance. GBE showed a protective effect against dissolution. EDX showed that the calcium content of the GM-treated group significantly decreased. However, the GBE-treated group demonstrated an insignificant change in the calcium concentration compared with the control. CONCLUSION:From these results, we can conclude that GBE may have a protective effect against GM-induced NO production and superficial structural changes.

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“…It acts as an antioxidant and has been shown to significantly reduce GM-induced NO production in cochlear cultures [16,17,24] . Our previous report showed that GBE significantly minimizes cochlear damage against endotoxin-induced otitis media with labyrinthitis in a guinea pig model [28] . In the present study, GM-induced NO production was reduced by GBE treatment, and the surface structure was protected.…”

Section: Discussionmentioning

confidence: 93%

Untitled

2016

Int Adv Otol

0

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OBJECTIVE:To evaluate the protective effect of Ginkgo biloba extract (GBE) on gentamicin (GM)-induced morphological damage of an artificial otoconia. MATERIALS and METHODS:An artificial otoconia powder was placed in a 12-well culture plate containing artificial endolymph. GM (500 μL; 40 mg/mL) was added to the first four wells. GM (500 μL; 40 mg/mL) with GBE (500 μL) was added to the next four wells. PBS (500 μL) was added to the remaining four wells as a control. The levels of nitric oxide (NO) synthesis were determined in the supernatants of each group. Alteration in surface morphology and calcium content were determined by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX), respectively. RESULTS:NO concentration increased in the GM-treated group compared with that in the control group. When the calcite-gelatin composite was treated with GBE, GM-stimulated NO production significantly decreased. The surface of the calcite-gelatin composite exposed to GM showed erosive fissures and had a honeycomb-like appearance. GBE showed a protective effect against dissolution. EDX showed that the calcium content of the GM-treated group significantly decreased. However, the GBE-treated group demonstrated an insignificant change in the calcium concentration compared with the control. CONCLUSION:From these results, we can conclude that GBE may have a protective effect against GM-induced NO production and superficial structural changes.

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“…The animals were treated with 100 mg/kg of GB for 3 days. The results indicated that this herbal extract strongly inhibited the mentioned effects arose from LPS toxicity (Jang et al, 2011). The specific cellular and molecular mechanisms involved in GB protection against LPS-ototoxicity have not been investigated.…”

Section: Earmentioning

confidence: 94%

“…It is likely because of its different composition. Furthermore, a novel method was applied by one of these studies conducted by Jang et al () to minimize the environment‐dependent genomic variations in the extract content by isolating a kind of stem cells of GB plant as a generating source of active ingredients. They cultured the cambial meristematic cells of the GB roots, which are the vascular stem cells and prepared the ethanolic extraction of the cells with a special protocol (Jang et al, ).…”

Section: Natural Toxinsmentioning

confidence: 99%

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

Omidkhoda

¹

,

Razavi

²

,

Hosseinzadeh

³

2019

Phytotherapy Research

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Nowadays in our developing and industrial world, humans' health or even their life is threatened by exposure to poisons. In this situation, detecting a protective compound could be helpful and interesting. In the present article, we collected and reviewed all studies, which have been conducted so far about the protective effects of Ginkgo biloba L. (GB), one of the most ancient medicinal tree species, against toxicities induced by chemical toxic agents, natural toxins, and also radiation. In overall, investigations showed that GB exerts the antioxidant, antiinflammatory, antiapoptotic, and antigenotoxicity effects in different toxicities. There are also some special mechanisms about its protective effects against some specific toxic agents, such as acetylcholine esterase inhibition in the aluminium neurotoxicity or membrane‐bond phosphodiesterase activation in the triethyltin toxicity. Ginkgolide A was the most investigated active ingredient of G. biloba leaf extract as a protective compound against toxicities, which had the similar effects of total extract. A few clinical studies have been conducted in this field, which demonstrated the beneficial effects of GB against toxic agents. However, the promising effects of this valuable herbal extract will practically remain useless without carrying out more clinical studies and proving its effects on human beings.

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Effect of Ginkgo biloba extract on endotoxin-induced labyrinthitis

Cited by 14 publications

References 22 publications

Protective Effect of Ginkgo Biloba Extract on Gentamicin-Induced Structural Changes of Calcite-Gelatin Composite

Protective Effect of Ginkgo Biloba Extract on Gentamicin-Induced Structural Changes of Calcite-Gelatin Composite

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Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

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