Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man

Hvidberg, A.; Nielsen, Mai-Britt; Hilsted, J.; Ørskov, Cathrine; Holst, Jens J.

doi:10.1016/0026-0495(94)90164-3

Cited by 180 publications

(111 citation statements)

References 13 publications

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“…Several studies have indicated that GLP-1 might have an insulin-independent effect on glucose homeostasis [26][27][28][29][30][31][32], while other researchers suggested that GLP-1 did not acutely affect glucose metabolism independently of insulin [33][34][35][36][37]. These conflicting results may be a consequence of the large variability in the model and methods used: healthy vs diabetic, diabetic hyperglycaemic vs diabetic maintained euglycaemic, clamp vs IVGTT etc.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones

et al. 2005

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“…Whereas GIP enhances glucagon release (73), GLP-1 suppresses it. The suppression of glucagon secretion may contribute to the beneficial metabolic effect of GLP-1 because of the consequent reduction in hepatic glucose output (74). The mechanisms by which GLP-1 suppresses glucagon release remains a mystery because GLP1R is only detected on ;10% or less of glucagon-producing a-cells (75).…”

Section: Gut Endocrine Regulation Of Glucose Metabolismmentioning

confidence: 99%

Roles of the Gut in Glucose Homeostasis

et al. 2016

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The gastrointestinal tract plays a major role in the regulation of postprandial glucose profiles. Gastric emptying is a highly regulated process, which normally ensures a limited and fairly constant delivery of nutrients and glucose to the proximal gut. The subsequent digestion and absorption of nutrients are associated with the release of a set of hormones that feeds back to regulate subsequent gastric emptying and regulates the release of insulin, resulting in downregulation of hepatic glucose production and deposition of glucose in insulin-sensitive tissues. These remarkable mechanisms normally keep postprandial glucose excursions low, regardless of the load of glucose ingested. When the regulation of emptying is perturbed (e.g., pyloroplasty, gastric sleeve or gastric bypass operation), postprandial glycemia may reach high levels, sometimes followed by profound hypoglycemia. This article discusses the underlying mechanisms.

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“…GLP-1(7-33), GLP-1(7-34) and GLP-1(7-35)) and no cross-reactivity with exendin-4. The detection limit was <1 pmol/l [18,19]. Antiserum Her4 (obtained from Dr Dominique Bataille, Inserm U 376, Montpellier, France) requires the intact N-terminus of the GLP-1 molecule.…”

Section: Hormonal Analysismentioning

confidence: 99%

Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

2006

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Aims/hypothesis: The insulinotropic hormone, glucagon-like peptide-1 (GLP-1), is rapidly degraded in vivo as a result of the combination of extensive enzymatic degradation and renal extraction. The GLP-1 receptor agonist, exendin-4, has a longer duration of action, and has recently been approved as a new agent for the treatment of type 2 diabetes mellitus. Exendin-4 is less prone to enzymatic degradation, but it is still unclear what other factors contribute to the increased metabolic stability. Materials and methods:The overall metabolism of GLP-1 and exendin-4 was directly compared in anaesthetised pigs (n=9). Results: Metabolism of GLP-1 (C-terminal RIA; t 1/2 2.0±0.2 min, metabolic clearance rate [MCR] 23.2±2.8 ml min −1 kg −1 ; N-terminal RIA; t 1/2 1.5±0.2 min, MCR 88.1±10.6 ml min −1 kg −1 ) was significantly faster than the metabolism of exendin-4 (t 1/2 22.0±2

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Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man

Cited by 180 publications

References 13 publications

Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones

Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones

Roles of the Gut in Glucose Homeostasis

Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs

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