Effect of glucocorticoids on contractile apparatus of rat skeletal muscle

Seene, Teet; Umnova, M. M.; Alev, Karin; Pehme, Ando

doi:10.1016/0022-4731(88)90032-5

Cited by 30 publications

(36 citation statements)

References 14 publications

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“…Results of our study show that degradation rate of contractile proteins in skeletal muscle during ageing increased about two times, and dexamethasone treatment increased the degradation rate in both age groups significantly. Our previous works has shown that dexamethasone associated degradation starts from the periphery of myofibrils in muscle fibers with low oxidative potential [9]. First of all, this destruction process starts from the myosin filaments, and after that, spreads all over the myofibrillar apparatus [9].…”

Section: Discussionmentioning

confidence: 99%

“…As the turnover rate of contractile proteins in ageing animals [10] and in young adults after excess of glucocorticoids [1] decreases, and precursor cells required for muscle regrowth are morphologically and functionally damaged [9], these changes together may be one of the reasons for sarcopenia. The mechanisms responsible for sarcopenia in aged skeletal muscle are largely unknown, but muscle satellite cells required for repair of fibers exhibit impaired activation [11] and proliferation [12] compared to young muscle.…”

Section: Introductionmentioning

confidence: 99%

“…doi:10.1016/j.jsbmb. 2006.11.024 and thin filaments and disintegration of individual myofibrils [9].…”

Section: Introductionmentioning

confidence: 99%

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Ageing and dexamethasone associated sarcopenia: Peculiarities of regeneration

Kaasik

Umnova

Pehme

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ageing and dexamethasone associated sarcopenia: Peculiarities of regeneration

Kaasik

Umnova

Pehme

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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“…Overproduction and overuse of glucocorticoids cause muscle atrophy and loss of muscle function [25], particularly destruction of myofilaments [26]. To date, however, the effects of glucocorticoids on skeletal muscle connective tissue have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise

Ahtikoski

Riso

Koskinen

et al. 2004

Pfl�gers Archiv European Journal of Physiology

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Glucocorticoids have anti-anabolic effects on many tissues and can cause muscle atrophy. However, their effects on type IV collagen gene expression and degradation in skeletal muscle have not been studied previously. Rats were treated daily with dexamethasone or saline. Half the groups of experimental and control animals were also subjected to daily endurance or uphill running exercise to determine the possible preventive effects of exercise. After an experimental period of 3 or 10 days, the extensor digitorum longus, soleus and tibialis anterior muscles were studied. Dexamethasone treatment for 10 days reduced muscle weight and type IV collagen mRNA abundance in all muscles. Gene expression of matrix metalloproteinase-2 (MMP-2) was decreased in fast muscles. However, the effects of this decrease were possibly attenuated by the simultaneous decrease in the activity of tissue inhibitor of metalloproteinases (TIMP-2). The amount of type IV collagen was not changed during dexamethasone treatment or exercise. The regulation of type IV collagen degradation during dexamethasone treatment varied between slow and fast muscles. Although endurance running prevented muscle atrophy, exercise could not compensate the changes observed in the regulation of type IV collagen gene expression and degradation during dexamethasone treatment.

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“…21 There are few case reports in the literature regarding respiratory muscle strength [22][23][24] and the serial level of muscle degradation enzymes. 25,26 In the literature there are reports that suggest that exercise programs improve physical performance in patients undergoing BMT, 27 but these studies have evaluated other parameters and did not directly address muscle strength. The purpose of this study was to analyze how an exercise program may affect the muscle strength of patients undergoing BMT.…”

mentioning

confidence: 99%

Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation

Mello

Tanaka

Dulley

2003

Bone Marrow Transplant

162

143

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Summary:Allogeneic bone marrow transplantation (BMT) has been successfully used for the treatment of several hematological malignancies; however, it is associated with transplant-related toxicities such as functional impairment and muscle weakness. In order to analyze how an exercise program may influence muscle strength in patients undergoing BMT, we carried out a prospective study assessing patients from the pre-BMT phase to 16 weeks post-BMT. In all, 18 patients underwent three trials: (1) pre-BMT, (2) after marrow engraftment, and (3) 6 weeks after trial 2. After trial 2, the patients were randomized in a control group (CG) or treatment group (TG), which received a 6-week exercise program with active exercise, muscle stretching and treadmill walking. The results obtained in trial 1 showed similar values for CG and TG, as both groups had muscle strength lower than normal patterns based on data concerning age, sex and weight. In trial 2, CG and TG showed similarly decreased values. In trial 3, TG showed values higher than CG for all muscle groups tested. These results suggest that the exercise program was efficient in promoting an increase of muscle strength after allogeneic BMT.

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Effect of glucocorticoids on contractile apparatus of rat skeletal muscle

Cited by 30 publications

References 14 publications

Ageing and dexamethasone associated sarcopenia: Peculiarities of regeneration

Ageing and dexamethasone associated sarcopenia: Peculiarities of regeneration

Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise

Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation

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