Effect of glucometabolic disorders on the formation of coronary collaterals in occlusive coronary artery disease

Nurkalem, Zekeriya; Görgülü, Şevket; Uslu, Nevzat; Alper, Ahmet Taha; Orhan, Ahmet Lütfüllah; Şahin, İrfan; Erer, Betul; Sargın, Mehmet; Eren, Mehmet

doi:10.2143/ac.63.2.2029519

Cited by 6 publications

(3 citation statements)

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“…Additionally, the Interventional Management of Stroke III Trial recently showed that a robust collateral grade was associated with better recanalization, reperfusion and clinical outcome 26. Since coronary collateral development has been shown to be worse in diabetic patients than in non-diabetic patients with myocardial ischemia,27 we suggest that the low rate of recanalization for diabetes with LVO may be associated with poor collateral flow in diabetes. However, this assumption needs to be validated in future studies.…”

Section: Discussionmentioning

confidence: 78%

Unfavorable neurological outcome in diabetic patients with acute ischemic stroke is associated with incomplete recanalization after intravenous thrombolysis

Tang

Zhang

Yan

et al. 2015

J NeuroIntervent Surg

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Section: Discussionmentioning

confidence: 78%

Unfavorable neurological outcome in diabetic patients with acute ischemic stroke is associated with incomplete recanalization after intravenous thrombolysis

Tang

Zhang

Yan

et al. 2015

J NeuroIntervent Surg

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“…Prior studies that examined the role of clinical factors on coronary collateralization have yielded conflicting results: For example, in some studies, diabetes mellitus was found to be a negative predictor of the presence of collaterals [30], [31], [32], [33], [34], while in others it was not [35], [36], [37], [38], [39]. In the present study, we found a negative association between diabetes mellitus and coronary collateralization and a positive association with hyperlipidemia, but independent of HMG-CoA reductase inhibitor therapy as has been reported by others [40], [41].…”

Section: Discussionmentioning

confidence: 99%

Plasma Chemokine Levels Are Associated with the Presence and Extent of Angiographic Coronary Collaterals in Chronic Ischemic Heart Disease

et al. 2011

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BackgroundIn patients with chronic ischemic heart disease (IHD), the presence and extent of spontaneously visible coronary collaterals are powerful determinants of clinical outcome. There is marked heterogeneity in the recruitment of coronary collaterals amongst patients with similar degrees of coronary artery stenoses, but the biological basis of this heterogeneity is not known. Chemokines are potent mediators of vascular remodeling in diverse biological settings. Their role in coronary collateralization has not been investigated. We sought to determine whether plasma levels of angiogenic and angiostatic chemokines are associated with of the presence and extent of coronary collaterals in patients with chronic IHD.Methodology/Principal FindingsWe measured plasma concentrations of angiogenic and angiostatic chemokine ligands in 156 consecutive subjects undergoing coronary angiography with at least one ≥90% coronary stenosis and determined the presence and extent of spontaneously visible coronary collaterals using the Rentrop scoring system. Eighty-eight subjects (56%) had evidence of coronary collaterals. In a multivariable regression model, the concentration of the angiogenic ligands CXCL5, CXCL8 and CXCL12, hyperlipidemia, and an occluded artery were associated with the presence of collaterals; conversely, the concentration of the angiostatic ligand CXCL11, interferon-γ, hypertension and diabetes were associated with the absence of collaterals (ROC area 0.91). When analyzed according to extent of collateralization, higher Rentrop scores were significantly associated with increased concentration of the angiogenic ligand CXCL1 (p<0.0001), and decreased concentrations of angiostatic ligands CXCL9 (p<0.0001), CXCL10 (p = 0.002), and CXCL11 (p = 0.0002), and interferon-γ (p = 0.0004).Conclusions/SignificancePlasma chemokine concentrations are associated with the presence and extent of spontaneously visible coronary artery collaterals and may be mechanistically involved in their recruitment.

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“…There is objective evidence of left ventricular systolic/ diastolic dysfunction in patients with CSFP [36,37]. However, the effect of CSFP on left atrial function has been minimally investigated.…”

Section: Csfp and Left Atrial Functionmentioning

confidence: 99%

Left Atrial Dysfunction in Patients with Coronary Slow Flow

Liu¹,

Dong²,

Shui³

2021

Journal of Clinical Cardiology

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Effect of glucometabolic disorders on the formation of coronary collaterals in occlusive coronary artery disease

Abstract: In conclusion, our study results, which are in agreement with previous results, indicate that not only diabetic glucose tolerance but also impaired glucose tolerance has an adverse impact on the development of coronary collaterals.

Cited by 6 publications

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Unfavorable neurological outcome in diabetic patients with acute ischemic stroke is associated with incomplete recanalization after intravenous thrombolysis

Unfavorable neurological outcome in diabetic patients with acute ischemic stroke is associated with incomplete recanalization after intravenous thrombolysis

Plasma Chemokine Levels Are Associated with the Presence and Extent of Angiographic Coronary Collaterals in Chronic Ischemic Heart Disease

Left Atrial Dysfunction in Patients with Coronary Slow Flow

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