Effect of glucose-insulin-potassium solution on the exercise performance of patients with coronary artery disease

Kostis, John B.; George, Joseph; Hayase, Kiyoshi; Moreyra, Abel E.; Kuo, Peter T.

doi:10.1016/0002-8703(79)90048-6

Cited by 7 publications

(2 citation statements)

References 51 publications

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“…On the other hand, anaerobic glucolysis-stimulated by glucose administration-produces lactate accumulation which might add to the cell damage resulting from the ischemia. Contradictory effects of low and high glucose regimen on hemodynamics and angina pectoris have been reported (5,6,18). The possibility of different responses in different clinical situations, and to different dosages, is probable.…”

Section: Controlmentioning

confidence: 99%

Glucose‐Insulin‐Potassium‐Albumin Infusion in the Early Phase of Acute Myocardial Infarction—A Controlled Study

Sundstedt

Sylvén

Mogensen

1981

Journal of Internal Medicine

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Fifty consecutive patients with acute myocardial infarction admitted to a coronary care unit within 6 hours from onset of symptoms were randomly assigned either to a treatment group ( n = 27) receiving glucose-insulirr-potassium-albumin (GIKA) or to a control group (n=23), comparable regarding clinical data, receiving 5.5 % glucose. Both infusions were given intravenously at a rate of 1.2 ml/kg b.wt./hour during 48 hours. The GIKA solution contained 40 mEq K+, 10 ml 20% albumin and 16 IU regular crystalline insulin per 1000 ml 10 % glucose. Before the infusion, the treatment group received an i.v. loading dose of 50 ml 50% glucose. Serum time activity curves for creatine kinase (CK) and myoglobin (MG) were established from frequent blood Level determinations. A 15minute single-lead ECG was recorded every fourth hour and subsequently analysed for ventricular arrhythmias. The two patient groups did not differ regarding cumulative MG and CK release. The GIKA group had significantly more patients with high MG/CK ratios (p<0.02). No clinically significant difference was found between the two patient groups regarding ventricular arrhythmias, even if ventricular extrasystoles tended to occur less frequently in the GIKA group.

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Section: Controlmentioning

confidence: 99%

Glucose‐Insulin‐Potassium‐Albumin Infusion in the Early Phase of Acute Myocardial Infarction—A Controlled Study

Sundstedt

Sylvén

Mogensen

1981

Journal of Internal Medicine

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“…In non-diabetic patients with ischemic heart disease, insulin showed beneficial effects such as diminution of the frequency of ventricular arrhythmias (3) and improvement of myocardial contractility (4) or in some patients, did not (5). In diabetic patients with ischemic heart disease, insulin contributed to a decrease in the mortality rate (6) or in other cases, did not (7).…”

mentioning

confidence: 99%

Improvement of Hypoperfusion with Norepinephrine Injury by Ex Vivo Insulin in Isolated Diabetic Rat Hearts

Ikema

Higuchi

Hirayama

et al. 1990

Japanese Journal of Pharmacology

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Abstract-Effects of insulin on contractile and energy metabolic dysfunctions during hypoperfusion (2 ml/min/g heart wt., 60 min) with 10-6 M norepinephrine were studied in paced hearts isolated from streptozotocin-diabetic rats. Insulin (2 mU/ min/g heart wt.) was infused 20 min before and during hypoperfusion (pre-treated group) or 30 min after the onset of hypoperfusion (post-treated group). Hearts in the non-treated group were hypoperfused without insulin and other hearts in the control group were not hypoperfused.In the non-treated group, resting con tractile force (CF) and resting left ventricular pressure (LVP) were significantly elevated to maximum levels within 30 min after hypoperfusion and these elevations were restored in the pre-treated group but not in the post-treated group. Developed CF was depressed in the non-treated group and improved significantly in the pre treated group but not in the post-treated group. Developed LVP was depressed in the non-treated group, and depression was slightly larger in the pre-treated group. In the non-treated group, ATP and creatine phosphate contents in the left ventricle significantly decreased. Decreases in ATP and creatine phosphate contents in the inner layer were partially restored in the pre-treated group but not in the post treated group. Lactate significantly increased in the non-treated group and increased even further in the insulin treated groups.These results indicate that contractile dysfunction during hypoperfusion with norepinephrine is improved by pre-treated insulin, as is partial recovery of energy metabolism.

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Underperfusion Injury in Diabetic Rat Hearts: Effects of Norepinephrine and/or Insulin on Stiffness Increase and Abnormal Energy Metabolism

Higuchi

Miyagi

Sakanashi

Progress in Experimental Cardiology

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Effect of glucose-insulin-potassium solution on the exercise performance of patients with coronary artery disease

Cited by 7 publications

References 51 publications

Glucose‐Insulin‐Potassium‐Albumin Infusion in the Early Phase of Acute Myocardial Infarction—A Controlled Study

Glucose‐Insulin‐Potassium‐Albumin Infusion in the Early Phase of Acute Myocardial Infarction—A Controlled Study

Improvement of Hypoperfusion with Norepinephrine Injury by Ex Vivo Insulin in Isolated Diabetic Rat Hearts

Underperfusion Injury in Diabetic Rat Hearts: Effects of Norepinephrine and/or Insulin on Stiffness Increase and Abnormal Energy Metabolism

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