1972
DOI: 10.1136/adc.47.252.179
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Effect of Glucose on Plasma Glucagon, Growth Hormone, and Insulin in Exchange Transfusion

Abstract: . (1972). Archives of Disease in Childhood, 47, 179. Effect of glucose on plasma glucagon, growth hormone, and insulin in exchange transfusion. Exchange transfusions were performed on term normal-for-dates, and term small-for-dates infants using blood preserved with acid citrate and glucose or acid citrate alone. The plasma concentrations of glucose, free fatty acids, glycerol, insulin, glucagon, and growth hormone were measured in the donor blood and in blood from the infant at different times during the tran… Show more

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Cited by 25 publications
(34 citation statements)
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“…The mean pre-transfusion plasma FFA levels were the lowest and highest observed in a series of investigations carried out under comparable conditions (6,7). In each of these studies the mean plasma FFA level at the 400-ml point was between 400 and 700 /umol/1 but the fall during transfusion varied between 200 and 850 jumol/1.…”
Section: Discussionmentioning
confidence: 75%
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“…The mean pre-transfusion plasma FFA levels were the lowest and highest observed in a series of investigations carried out under comparable conditions (6,7). In each of these studies the mean plasma FFA level at the 400-ml point was between 400 and 700 /umol/1 but the fall during transfusion varied between 200 and 850 jumol/1.…”
Section: Discussionmentioning
confidence: 75%
“…The total volume of blood removed was such as to leave the infant in the final desired haemic balance. Plasma was separated and stored and the haematocrit and plasma glucose, free fatty acid (FFA), insulin and GH concentrations were measured as described previously (7). The two forms of transfusion were compared by analysing the mean plasma concentration, the mean change in plasma concentration from the start of transfusion or 5 min post-transfusion and the mean total amount of metabolite or hormone infused and removed.…”
Section: Methodsmentioning
confidence: 99%
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“…In addition, in species such as sheep and rabbit in which plasma glucose levels do not decrease at birth, an acute increase of plasma glucagon can nevertheless be observed [40,42]. On the other hand, direct evidence of the inability of glucose to reduce glucagon secretion in the newborn has been indicated by in vivo studies in the rat [59] and human [38,60]. The neonatal insensitivity to hyperglycemia has been pro posed to be due in part to low glucoseinduced insulin release of the neonatal pancreas [61].…”
Section: Effect Of Glucose On Glucagon Secretion In the Newbornmentioning
confidence: 89%
“…The initial rise had been observed by earlier workers also (13) and was reported to be due to the administration of calcium gluconate (100 mg for every 100 mt exchanged blood) in order to counteract any fall in serum ionized calcium levels (17,18,19). Such fall occurs d ue to calcium chelating properties of citrate which is present in high concentration in the donor's blood where it is used as an anticoagulant (19,20). However, in the present study calcium gluconate was not administered at all (1).…”
Section: Calciummentioning
confidence: 75%