Effect of glucose on the stress–strain behavior of ex-vivo rabbit cornea

Ni, Shouxiang; Yu, Ji-guo; Bao, Fangjun; Li, Jinyang; Elsheikh, Ahmed; Wang, Qinmei

doi:10.1016/j.exer.2011.02.005

Cited by 28 publications

(19 citation statements)

References 63 publications

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“…It is noteworthy that patients with proliferative, non-proliferative retinopathies and those with no diabetic retinopathies did not have significantly different corneal thicknesses. 90, 97, 98, 99, 100 In addition, a study in 100 children aged 6–17 years with type 1 DM in Romania had an increase in corneal thickness compared with an equivalent number of children of the same age, 101 and similar findings had been reported in Turkey. 96 …”

Section: Cornea Stroma and Biomechanicssupporting

confidence: 55%

A systematic review on the impact of diabetes mellitus on the ocular surface

2017

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Diabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment. In addition, alterations of immune cells in corneas suggest an inflammatory component in diabetic complications. Furthermore, impaired corneal epithelial wound healing may also imply more widespread disease. The non-invasiveness and improvement in imaging technology facilitates the emergence of new screening tools. Systemic control of diabetes can improve ocular surface health, possibly aided by anti-inflammatory and vasoprotective agents.

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Section: Cornea Stroma and Biomechanicssupporting

confidence: 55%

A systematic review on the impact of diabetes mellitus on the ocular surface

2017

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“…The present study aims to assess the relationships between the ORA and CVS metrics on one hand, and IOP and CCT on the other. The study relied on rabbit corneas (Wollensak and Iomdina, 2009), (Ni et al, 2011) similar to earlier work which found the rabbit corneas a suitable, approximate model for human corneas in mechanical property characterization studies. This is especially important in light of the need to acquire statistically significant material property data, which is difficult to obtain from human donor corneas.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the relationship of corneal biomechanical metrics with physical intraocular pressure and central corneal thickness in ex vivo rabbit eye globes

Bao

Deng

Wang

et al. 2015

Experimental Eye Research

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“…The stimulus can be induced in many ways, e.g., exciting with mechanical force, 6,7 acoustic radiation force, 8 or by using a laser pulse. 9 Combining different stimuli and methods to measure the mechanical response to these stimuli, several elasticity imaging modalities have been proposed such as magnetic resonance elastography, 7,10-12 ultrasound elastography, 13,14 acoustic radiation force imaging, 15,16 and supersonic shear imaging. 8,17,18 However, all of these methods require significant amplitude of tissue stimulation in order to produce a measurable signal.…”

mentioning

confidence: 99%

“…22 Since then, several groups have been utilizing OCT to obtain the biomechanical properties of tissues. 9,[23][24][25][26] De la Torre et al have measured displacement fields with a sensitivity of 10 nm in porcine cornea ex vivo.…”

mentioning

confidence: 99%