Effect of glutamine in patients with esophagus resection

Márton, Sándor; Ghosh, Subhamay; Papp, András; Bogár, Lajos; Kőszegi, Tamás; Juhász, Vera P.; Cseke, László; Horváth, Péter

doi:10.1111/j.1442-2050.2009.01007.x

Cited by 11 publications

(9 citation statements)

References 14 publications

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“…Ten trials [ 19 , 20 , 22 , 40 , 41 , 42 , 43 , 44 , 47 , 48 ], including 900 patients, provided data on postoperative mortality. However, only in four studies at least one event was observed.…”

Section: Resultsmentioning

confidence: 99%

“…The first meta-analysis by Novak et al [ 24 ] was published in 2002 and the second by Zheng in 2006 [ 25 ]. Since than another seven RCTs [ 19 , 22 , 45 , 46 , 47 , 48 , 49 ] have become available in the literature and, therefore, the different conclusions may be justified by the number of trials analyzed. Another two more recent meta-analyses published in 2010 [ 26 ] and 2013 [ 23 ] suggested that glutamine supplementation in this specific cohort of patients was associated with a significant better outcome as measured by postoperative infection rate and LOS.…”

Section: Discussionmentioning

confidence: 99%

“…Wang [ 26 ] included 447 patients enrolled in 10 trials reporting on infectious morbidity, and the study search was interrupted in October 2008. Since then, another five RCTs have been published [ 46 , 47 , 48 , 49 ] and the overall number of patients considerable for analysis has more than doubled. In the latest meta-analysis investigating the role of parenteral glutamine, published by Bollhalder et al [ 23 ], a significant protective effect of treatment on infectious morbidity was observed for RCTs on surgical patients (risk ratio of 0.61, 95% CI 0.46 to 0.82).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major Surgery: Systematic Review and Meta-Analysis

et al. 2015

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To evaluate if glutamine (GLN) supplementation may affect primary outcomes in patients undergoing major elective abdominal operations, we performed a systematic literature review of randomized clinical trials (RCTs) published from 1983 to 2013 and comparing intravenous glutamine dipeptide supplementation to no supplementation in elective surgical abdominal procedures. A meta-analysis for each outcome (overall and infectious morbidity and length of stay) of interest was carried out. The effect size was estimated by the risk ratio (RR) or by the weighted mean difference (WMD). Nineteen RCTs were identified with a total of 1243 patients (640 receiving GLN and 603 controls). In general, the studies were underpowered and of medium or low quality. GLN supplementation did not affect overall morbidity (RR = 0.84, 95% CI 0.51 to 1.36; p = 0.473) and infectious morbidity (RR = 0.64; 95% CI = 0.38 to 1.07; p = 0.087). Patients treated with glutamine had a significant reduction in length of hospital stay (WMD = −2.67; 95% CI = −3.83 to −1.50; p < 0.0001). In conclusion, GLN supplementation appears to reduce hospital stay without affecting the rate of complications. The positive effect of GLN on time of hospitalization is difficult to interpret due to the lack of significant effects on surgery-related morbidity.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major Surgery: Systematic Review and Meta-Analysis

et al. 2015

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“…Meanwhile, Marton et al. demonstrated that perioperative glutamine supplementation had no influence on morbidity, mortality, and postoperative inflammatory response after esophagectomy [16]. As little is known of the effects of intravenous amino acid supplementation during recovery from surgical stress on early postoperative period, we assessed the effects of intravenous amino acid supplementation via peripheral veins, following radical esophagectomy for esophageal cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Peripheral vein infusions of amino acids facilitate recovery after esophagectomy for esophageal cancer: Retrospective cohort analysis

Konosu

Iwaya

Kimura

et al. 2017

Annals of Medicine &Amp; Surgery

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BackgroundTo investigate the efficacy of amino acid administration via peripheral veins in addition to conventional enteral feeding following esophagectomy.Materials and methodsRetrospective analysis of data pertaining to 33 patients with esophageal cancer who underwent radical esophagectomy and satisfied the required nutrition control. Patients were divided into the amino acid group (n = 17) and control group (n = 16). Primary outcomes were albumin (Alb) and prealbumin (PreAlb) levels, urinary 3-methylhistidine/creatinine (3-MeHis/Cre) ratios, nitrogen balance, and weight; postoperative complications were noted as secondary outcomes.ResultsAlb levels were significantly higher in the amino acid group on postoperative day (POD)-14 (3.4 ± 0.3 vs. 3.1 ± 0.4 mg/dL in the control group, p = 0.018) and at 1 month after surgery (3.8 ± 0.4 vs. 3.5 ± 0.3 mg/dL, p = 0.045). No significant differences were observed in PreAlb and urinary 3-MeHis/Cre rates between the treatment groups. Body weights at 3 months postoperatively were decreased by 6% and 3% in the control and amino acid groups, respectively.ConclusionPeripheral venous administration of amino acids soon after surgical stress is an effective method for nutritional control.

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“…Mixed Makay et al 63 Omega-3 Postoperative 30 n.s. Marton et al 65 Glutamine Perioperative 30 Mixed Morlion et al 68 Glutamine Postoperative 29 n.s. Neri et al 70 Glutamine Postoperative 30 n.s.…”

Section: Data Extractionmentioning

confidence: 99%