Effect of glutathione on cholerogenic diarrhea and on distrubances of the antioxidative system of rat intestinal and liver cells

Yurkiv, V. A.; Popkova, N. I.; Герасимов, А. М.

doi:10.1007/bf00837860

Cited by 1 publication

(1 citation statement)

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“…It also claims to improve milk yield of cows and goats, milk quality, prolong the milking peak period, and decrease the rate of cow mastitis. Moreover, Iurkiv et al (1985) reported that diarrhea syndrome was found to decrease markedly after GSH administration at a dose of 1 g/kg BW. In addition, the polyfunctional cellular activity of GSH suggests that the anti-diarrhea effect should be considered as an element of pathogenetic therapy.…”

Section: Feed Intake and Growth Performancementioning

confidence: 99%

Effect of Dietary Supplementation of Glutathione on Blood Biochemical Changes and Growth Performances of Holstein Calves

Kim¹,

Mamuad²,

Lee³

et al. 2011

Asian Australas. J. Anim. Sci

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The objective of this experiment was to evaluate the effect of dietary supplementation of glutathione (GSH) on health, solid feed consumption, nutrient intake, body weight gain (BWG), feed efficiency, blood metabolites and the occurrence of diarrhea in Holstein neonatal calves. The calves were fed plain milk as a control (CON) or milk with GSH supplementation. Sixteen calves were separated from their mothers immediately after birth, moved into individual cages and fed colostrum for the first three days. For GSH supplementation, three grams of GSH powder were mixed in 1.8 L of heat-treated milk and placed in a plastic bottle with a rubber nipple. The calves were fed GSH-supplemented milk only once out of four daily feedings. For the first 25 d, calves were fed 1.8 L of milk four times per day. Milk feeding frequency was reduced to three times per day from days 26 to 30, followed by twice a day from days 31 to 44, and once a day from days 45 to 49, after which they were weaned at day 50. Body weight gain (BWG), feed consumption, and growth performance were monitored until day 70. The dietary supplementation of GSH had no effect on daily feed intake and growth performance in growing calves. Hematological results revealed red blood cell distribution width (RDW) was lower, and mean corpuscular volume (MCV) was significantly higher in calves fed GSH. Serum lactate dehydrogenase (LDH) concentrations were lower in calves fed GSH. Rectal temperature at day 70 was higher in calves that did not receive GSH, while mean frequency of diarrhea and enteritis was less in calves fed GSH. It is concluded from the present study that BW gain, total dry matter intake (DMI), feed efficiency, and breathing rate did not differ between groups. However, there were some positive blood parameters and the mean frequency of diarrhea and enteritis was less in calves fed GSH compared to CON which did not receive GSH. With the results obtained, supplementation of GSH is highly recommended.

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Section: Feed Intake and Growth Performancementioning

confidence: 99%